Principles of Cancer Treatment and Anticancer Drug Development, Wolfgang Link

Автор: Benjamin Winograd; Michael Peckham; Herbert M. Pin
Название: Human Tumour Xenografts in Anticancer Drug Development
ISBN: 3642732542 ISBN-13(EAN): 9783642732546
Издательство: Springer
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Цена: 19591.00 р.
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Описание: Seminar on Human Tumour Xenografts 1986, Milan, Italy. European School of Oncology

Автор: Beverly A. Teicher
Название: Anticancer Drug Development Guide
ISBN: 1461581540 ISBN-13(EAN): 9781461581543
Издательство: Springer
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Цена: 16979.00 р.
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Описание: Experienced cancer researchers from pharmaceutical companies, government laboratories, and academia comprehensively review and describe the arduous process of cancer drug discovery and approval.

Автор: Teicher
Название: Anticancer Drug Development Guide. 2ed.2004
ISBN: 1588292282 ISBN-13(EAN): 9781588292285
Издательство: Springer
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Цена: 34799.00 р.
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Описание: This thoroughly updated and expanded second edition of Beverly Teicher's widely used classic survey provides a step-by-step guide to anticancer drug development from initial design through FDA approval. The authors have included new material on the use of high throughput screening in industry, on specialized in vitro/in vivo procedures employed by the National Cancer Institute (NCI) in preclinical drug evaluations, and on nonclinical testing to support both human clinical trials, as well as trials of biologic oncology products. The chapters on phase I, II, and III clinical trials and on novel phase II clinical trial designs for targeted therapies have been significantly updated, along with those on cancer drug development in Europe, working with the NCI, and the FDA's role in cancer drug development and setting requirements for approval.

Автор: Carmen Avendano
Название: Medicinal Chemistry of Anticancer Drugs
ISBN: 0444626492 ISBN-13(EAN): 9780444626493
Издательство: Elsevier Science
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Цена: 23244.00 р.
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Описание: Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. . Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. . Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design.

Автор: Elizabeth Garrett-Mayer; Manuel Hidalgo; S. Gail E
Название: Principles of Anticancer Drug Development
ISBN: 1461427916 ISBN-13(EAN): 9781461427919
Издательство: Springer
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Цена: 26120.00 р.
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Описание: This is a practical guide to the design, conduction, analysis and reporting of clinical trials with anticancer drugs. It includes coverage of basic biostatistics for the clinical trialist, and fundamental concepts in clinical pharmacology.

Автор: Beverly A. Teicher; Paul A. Andrews
Название: Anticancer Drug Development Guide
ISBN: 146849841X ISBN-13(EAN): 9781468498417
Издательство: Springer
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Цена: 20962.00 р.
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Описание: Since the earliest widely used in vivo drug screening models were the murine L 1210 and P388 leukemias, the community came to assume that these murine tumor models were appropriate to the discovery of "antileukemia" agents, but that other tumor models would be needed to discover drugs active against solid tumors.

Автор: Ashkan Emadi, Judith E. Karp, Candace B. Mainor
Название: Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs
ISBN: 0826162037 ISBN-13(EAN): 9780826162038
Издательство: Mare Nostrum (Eurospan)
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Цена: 13860.00 р.
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Описание: Provides a one-stop guide to the essential basic and clinical science of all the effective, life-prolonging drug therapies in oncology. From traditional cytotoxic agents to targeted genomic, epigenomic, hormonal, and immunotherapeutic agents, this book covers the staggering advances in cancer pharmacology.

Автор: Robert F. Ozols
Название: Molecular and Clinical Advances in Anticancer Drug Resistance
ISBN: 0792312120 ISBN-13(EAN): 9780792312123
Издательство: Springer
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Цена: 37594.00 р.
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Описание: The importance of drug resistance in cancer chemotherapy cannot be over- stated. The 500,000 patients who die every year from cancer in the United States have, in most cases, been treated with chemotherapy. Many of these patients responded initially to chemotherapy, but death resulted from the development of drug-resistant tumors. In the first volume in the series. Drug Resistance in Chemotherapy the results of comprehensive laboratory studies aimed at understanding the mechanisms for resistance to individual agents and to the development of broad cross-resistance were described. In the past 2 years there has been substantial progress in understanding the molecular biology associated with these mechanisms of drug resistance. For the first time we are starting to understand which mechanisms are playing an im- portant role in human tumors, and even more importantly, clinical trials have recently been initiated in an effort to reverse specific forms of drug resistance. The purpose of this volume is to describe the new advances, both at the molecular level and in the clinic regarding mechanisms of drug resistance and potential ways this resistance can be circumvented. This volume is focused upon mechanisms of resistance associated with two major classes of anticancer drugs: alkylating agents (including cisplatin) and the natural products (e. g., adriamycin and vinblastine). The first section of the book describes new insights into the genetic mechanisms associated with drug resistance.