Neuronal Cell Signalling: From Out To In, Robbins Jon
Автор: Ernesto Carafoli; Marisa Brini Название: Calcium Signalling and Disease ISBN: 9048175607 ISBN-13(EAN): 9789048175604 Издательство: Springer Рейтинг: Цена: 36570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Authors highlight several promising discoveries in the field of calcium signaling that provide new information about both genetic and acquired pathologies. Their discussions will give you new insights into the underlying causes of congenital and acquired diseases and point the way to new, even more promising research and therapies.
Автор: Michela Chiappalone, Valentina Pasquale Название: In vitro neuronal networks : ISBN: 3030111342 ISBN-13(EAN): 9783030111342 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides a comprehensive overview of the incredible advances achieved in the study of in vitro neuronal networks for use in basic and applied research. These cultures of dissociated neurons offer a perfect trade-off between complex experimental models and theoretical modeling approaches giving new opportunities for experimental design but also providing new challenges in data management and interpretation. Topics include culturing methodologies, neuroengineering techniques, stem cell derived neuronal networks, techniques for measuring network activity, and recent improvements in large-scale data analysis. The book ends with a series of case studies examining potential applications of these technologies.
Автор: Denson G. Fujikawa Название: Acute Neuronal Injury ISBN: 3319774948 ISBN-13(EAN): 9783319774947 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: An overview of the biochemical mechanisms that produce acute nerve cell death in the brain. Covers injuries and disorders including stroke, brain and spinal cord trauma, hypoglycemic coma, and prolonged epileptic seizures. All of these lead to high concentrations of calcium in nerve cells which, in turn, causes degradation of cytoplasmic proteins, cleavage of nuclear DNA, and eventually cell death.The Second Edition contains 11 thoroughly updated chapters and 3 additional chapters that did not appear in the previous edition.
Автор: Dupont Название: Models of Calcium Signalling ISBN: 3319296450 ISBN-13(EAN): 9783319296456 Издательство: Springer Рейтинг: Цена: 12577.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book discusses the ways in which mathematical, computational, and modelling methods can be used to help understand the dynamics of intracellular calcium. The concentration of free intracellular calcium is vital for controlling a wide range of cellular processes, and is thus of great physiological importance. However, because of the complex ways in which the calcium concentration varies, it is also of great mathematical interest.This book presents the general modelling theory as well as a large number of specific case examples, to show how mathematical modelling can interact with experimental approaches, in an interdisciplinary and multifaceted approach to the study of an important physiological control mechanism.Genevi?ve Dupont is FNRS Research Director at the Unit of Theoretical Chronobiology of the Universit? Libre de Bruxelles; Martin Falcke is head of the Mathematical Cell Physiology group at the Max Delbr?ck Center for Molecular Medicine, Berlin; Vivien Kirk is an Associate Professor in the Department of Mathematics at the University of Auckland, New Zealand; James Sneyd is a Professor in the Department of Mathematics at The University of Auckland, New Zealand.
Biophysical Basis of Physiology and Calcium Signaling Mechanism in Cardiac and Smooth Muscle acts as a bridge between physiology and physics by discussing the physiology and calcium signaling mechanism in cardiac and smooth muscle. By exploring the mechanism of the cyclic release of stored Ca (2+) in the SR or ER, this book covers the cell communication system, including excitable cells, recognizing the most relevant mechanisms of cell communication. Serving as a bridge between physiology and physics, coverage spans the physiology and calcium signaling mechanism in cardiac and smooth muscle, offering insight to physiological scientists, pharmaceutical scientists, medical doctors, biologists and physicists.
Explores the mechanism of the cyclic release of stored Ca 2+ in the SR or ER
Provides in-depth coverage of cell communication systems to explain the most relevant mechanisms of cell communication
Covers the physiology and calcium signaling mechanism in cardiac and smooth muscle
Автор: I. Fairweather Название: Cell Signalling in Prokaryotes and Lower Metazoa ISBN: 9048164834 ISBN-13(EAN): 9789048164837 Издательство: Springer Рейтинг: Цена: 34799.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: To date, much of the understanding of signalling mechanisms has come from research on specific cell types (eg mouse lymphocyte and cardiomyocyte) or on organisms in which communication systems such as nervous and endocrine systems are well established.
Автор: Nicholson Sandra E., Nicola Nicos A. Название: Jak-Stat Signalling: Methods and Protocols ISBN: 1493959794 ISBN-13(EAN): 9781493959792 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The receptor-associated JAK protein kinases and their substrates, the STAT transcriptional activators, transmit signals following cytokine and growth factor binding to receptors expressed on the cell surface, to result in specific transcriptional and cellular responses. Over the last two decades, the field has progressed from identification of the individual components through to an understanding of the activation and deactivation mechanisms, and the complex structural detail of the proteins involved. We now know that these pathways are important in many biological processes, including growth and development, hematopoiesis, and the innate and adaptive immune response. JAK-STAT Signalling: Methods and Protocols provides detailed methodologies for examining many aspects of the pathway. Divided into four sections, topics include JAK and STAT specific approaches, the negative regulators of the pathway (SOCS proteins), and the production and crystallization of JAK and STAT proteins, among others. Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, JAK-STAT Signalling: Methods and Protocols will be of use not only to those working in the area but also to new investigators who are led to delve into the complexities of JAK and STAT responses.
Автор: Alexej Verkhratsky; Emil C. Toescu Название: Integrative Aspects of Calcium Signalling ISBN: 1489919031 ISBN-13(EAN): 9781489919038 Издательство: Springer Рейтинг: Цена: 28734.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Here is the first effort in a single volume to cover all of the integrative functions of calcium signalling - how changes in intracellular calcium coordinate a variety of coherent cellular responses.
Автор: Donev, Rossen Название: Intracellular Signalling Proteins ISBN: 0128155612 ISBN-13(EAN): 9780128155615 Издательство: Elsevier Science Рейтинг: Цена: 17517.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Intracellular Signalling Proteins, Volume 116, presents an overview of the current developments in mechanisms of intracellular signaling and involvement of these mechanisms in the development of a number of disorders and diseases. Opportunities for targeting the intracellular signaling cascades for benefiting patients are also discussed, along with chapters that focus on Voices from the Dead: The Complex Language of Dead Cells, Nucleobindins and Encoded Peptides: From Cell Signalling to Physiology, Estrogen Receptor Signaling Mechanisms, Intracellular Signaling of the AMP-Activating Protein Kinase, the Relationship between Mitofusin 2 and Cancer, Molecular Signaling in Bone Cells: Regulation Cell Differentiation and Survival, and more.
Describes advances in the discovery and application of therapeutics that target intracellular signaling mechanisms
Targeted to a very wide audience of specialists, researchers and students
Contains timely chapters written by well-renowned authorities in their field
Includes a number of high quality illustrations, figures and tables
Автор: Chatterjee, Shampa Название: Endothelial Signalling In Vascular Dysfunction And Disease ISBN: 0128161965 ISBN-13(EAN): 9780128161968 Издательство: Elsevier Science Рейтинг: Цена: 19370.00 р. Наличие на складе: Поставка под заказ.
Описание:
Endothelial Signaling in Vascular Dysfunction and Disease: From Bench to Bedside provides a detailed understanding of the endothelium, its activation and their link to some common clinical disorders. In addition, the book covers earlier discoveries, including those from the last and 19th centuries. It is split into five sections that cover the vascular tree as an integrative structure, the endothelium in inflammation, endothelial signaling, activation and toxicity with chemotherapy, radiation induced endothelial dysfunction and vascular disease, and therapies in combating vascular diseases. Each section is discussed with a translational approach in order to make the content truly applicable.
This book is a valuable source for basic researchers, clinicians in the fields of Oncology, Cardiovascular Medicine and Radiology, and members of the biomedical field who are conducting studies related to the endothelium and vascular disease.
Описание: From probe design to applications in clinical settings, this book provides a diverse set of instructive examples, guided by experts in the field who offer easy-to-follow experimentals.
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