Biophysical Basis of Physiology and Calcium Signaling Mechanism in Cardiac and Smooth Muscle acts as a bridge between physiology and physics by discussing the physiology and calcium signaling mechanism in cardiac and smooth muscle. By exploring the mechanism of the cyclic release of stored Ca (2+) in the SR or ER, this book covers the cell communication system, including excitable cells, recognizing the most relevant mechanisms of cell communication. Serving as a bridge between physiology and physics, coverage spans the physiology and calcium signaling mechanism in cardiac and smooth muscle, offering insight to physiological scientists, pharmaceutical scientists, medical doctors, biologists and physicists.
Explores the mechanism of the cyclic release of stored Ca 2+ in the SR or ER
Provides in-depth coverage of cell communication systems to explain the most relevant mechanisms of cell communication
Covers the physiology and calcium signaling mechanism in cardiac and smooth muscle
Описание: From probe design to applications in clinical settings, this book provides a diverse set of instructive examples, guided by experts in the field who offer easy-to-follow experimentals.
Автор: Donev, Rossen Название: Intracellular Signalling Proteins ISBN: 0128155612 ISBN-13(EAN): 9780128155615 Издательство: Elsevier Science Рейтинг: Цена: 17517.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Intracellular Signalling Proteins, Volume 116, presents an overview of the current developments in mechanisms of intracellular signaling and involvement of these mechanisms in the development of a number of disorders and diseases. Opportunities for targeting the intracellular signaling cascades for benefiting patients are also discussed, along with chapters that focus on Voices from the Dead: The Complex Language of Dead Cells, Nucleobindins and Encoded Peptides: From Cell Signalling to Physiology, Estrogen Receptor Signaling Mechanisms, Intracellular Signaling of the AMP-Activating Protein Kinase, the Relationship between Mitofusin 2 and Cancer, Molecular Signaling in Bone Cells: Regulation Cell Differentiation and Survival, and more.
Describes advances in the discovery and application of therapeutics that target intracellular signaling mechanisms
Targeted to a very wide audience of specialists, researchers and students
Contains timely chapters written by well-renowned authorities in their field
Includes a number of high quality illustrations, figures and tables
Автор: Schmidt Mirko Hh, Liebner Stefan Название: Endothelial Signaling in Development and Disease ISBN: 1493945459 ISBN-13(EAN): 9781493945450 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book surveys healthy and diseased vascular systems in a multitude of model organisms and systems. It explores a plethora of functions, characteristics, and pathologies of the vascular system such as angiogenesis, fibroblast growth factor signaling, lymphangiogenesis, junctional signaling, the extracellular matrix, vascular permeability, leukocyte extravasation, axon guidance factors, the angiopoietin system, and chronic obstructive lung disease. Following a preface from leading researcher Dr. Holger Gerhardt, the text is divided into three sections- the first examining the development of the vascular system in a variety of contexts, the second delving into its homeostatic characteristics, and the third discussing its pathophysiologies. The sixteen chapters, which represent international clinical and research perspectives, highlight the importance of molecular and signaling pathways for translational basic science and clinical medicine. Additionally, the text explores new and exciting fields in vascular biology research. Comprehensive in both content and approach, Vascular Signaling in Health and Disease is ideal for graduate students, researchers, and clinicians interested in vascular biology, pneumology, and molecular biology.
Автор: I. Fairweather Название: Cell Signalling in Prokaryotes and Lower Metazoa ISBN: 9048164834 ISBN-13(EAN): 9789048164837 Издательство: Springer Рейтинг: Цена: 34799.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: To date, much of the understanding of signalling mechanisms has come from research on specific cell types (eg mouse lymphocyte and cardiomyocyte) or on organisms in which communication systems such as nervous and endocrine systems are well established.
Автор: Dupont Название: Models of Calcium Signalling ISBN: 3319296450 ISBN-13(EAN): 9783319296456 Издательство: Springer Рейтинг: Цена: 12577.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book discusses the ways in which mathematical, computational, and modelling methods can be used to help understand the dynamics of intracellular calcium. The concentration of free intracellular calcium is vital for controlling a wide range of cellular processes, and is thus of great physiological importance. However, because of the complex ways in which the calcium concentration varies, it is also of great mathematical interest.This book presents the general modelling theory as well as a large number of specific case examples, to show how mathematical modelling can interact with experimental approaches, in an interdisciplinary and multifaceted approach to the study of an important physiological control mechanism.Genevi?ve Dupont is FNRS Research Director at the Unit of Theoretical Chronobiology of the Universit? Libre de Bruxelles; Martin Falcke is head of the Mathematical Cell Physiology group at the Max Delbr?ck Center for Molecular Medicine, Berlin; Vivien Kirk is an Associate Professor in the Department of Mathematics at the University of Auckland, New Zealand; James Sneyd is a Professor in the Department of Mathematics at The University of Auckland, New Zealand.
Автор: Ernesto Carafoli; Marisa Brini Название: Calcium Signalling and Disease ISBN: 9048175607 ISBN-13(EAN): 9789048175604 Издательство: Springer Рейтинг: Цена: 36570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Authors highlight several promising discoveries in the field of calcium signaling that provide new information about both genetic and acquired pathologies. Their discussions will give you new insights into the underlying causes of congenital and acquired diseases and point the way to new, even more promising research and therapies.
Автор: Alexej Verkhratsky; Emil C. Toescu Название: Integrative Aspects of Calcium Signalling ISBN: 1489919031 ISBN-13(EAN): 9781489919038 Издательство: Springer Рейтинг: Цена: 28734.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Here is the first effort in a single volume to cover all of the integrative functions of calcium signalling - how changes in intracellular calcium coordinate a variety of coherent cellular responses.
Автор: Nicholson Sandra E., Nicola Nicos A. Название: Jak-Stat Signalling: Methods and Protocols ISBN: 1493959794 ISBN-13(EAN): 9781493959792 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The receptor-associated JAK protein kinases and their substrates, the STAT transcriptional activators, transmit signals following cytokine and growth factor binding to receptors expressed on the cell surface, to result in specific transcriptional and cellular responses. Over the last two decades, the field has progressed from identification of the individual components through to an understanding of the activation and deactivation mechanisms, and the complex structural detail of the proteins involved. We now know that these pathways are important in many biological processes, including growth and development, hematopoiesis, and the innate and adaptive immune response. JAK-STAT Signalling: Methods and Protocols provides detailed methodologies for examining many aspects of the pathway. Divided into four sections, topics include JAK and STAT specific approaches, the negative regulators of the pathway (SOCS proteins), and the production and crystallization of JAK and STAT proteins, among others. Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, JAK-STAT Signalling: Methods and Protocols will be of use not only to those working in the area but also to new investigators who are led to delve into the complexities of JAK and STAT responses.
Автор: Robbins Jon Название: Neuronal Cell Signalling: From Out To In ISBN: 1848166125 ISBN-13(EAN): 9781848166127 Издательство: World Scientific Publishing Цена: 12830.00 р. Наличие на складе: Поставка под заказ.
Описание: This book provides an up-to-date view of the signal transduction pathways in neurones and neuronal cells. It will cover “classical neurotransmission” as well as other signalling pathways such as gaseous signalling and adhesion molecule signalling. Furthermore, global concepts such as signalling crosstalk, spatial and temporal signalling are discussed comprehensively.The study of cellular signalling is pivotal to understanding cell and tissue function. This book will be a learning aid as well as a source of reference, now that the cell signalling field has matured and made great strides.
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