High-Throughput Analysis in the Pharmaceutical Industry,
Автор: Perry G. Wang,Mark F. Vitha,Jack F. Kay Название: High Throughput Analysis for Food Safety ISBN: 1118396308 ISBN-13(EAN): 9781118396308 Издательство: Wiley Рейтинг: Цена: 17099.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book focuses on high-throughput analyses for food safety. Because of the contributors domestic and international expertise from industry and government the book appeals to a wider audience.
Название: High-Throughput Synthesis ISBN: 0367397544 ISBN-13(EAN): 9780367397548 Издательство: Taylor&Francis Рейтинг: Цена: 6736.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: An exploration of high-throughput synthesis, this book presents a compilation of how-to methods, novel materials, and catalyst developments for creating a multitude of new compounds. Introductory sections are coupled with in-depth case studies clarifying theory through practice. The book emphasizes the potential for reproducing experiments in detail.
Автор: Janzen Название: High Throughput Screening ISBN: 1493936719 ISBN-13(EAN): 9781493936717 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This third edition volumeexpands on the previous editions both by presenting more detailed protocols forthe techniques described in the first and second editions of High ThroughputScreening: Methods and Protocolsand by covering important new procedures. The first chapter ofthis book provides an overview of important assay development techniques, whilethe rest of the chapters detail how to develop and execute screens at whateverthroughput the user needs. Some chapter examples are: structure-based virtualscreening, high throughput screening using mass spectrometry, identification of state-dependentblockers for voltage gated calcium channels, bioluminescence resonanceenergy transfer platform to monitor protein-protein interactions in live cells,high throughput flow cytometry, and application of imaging-based assays in microplate formats for highcontent screening. Written in the highly successful Methods in MolecularBiology series format, chapters include introductions to their respectivetopics, lists of the necessary materials and reagents, step-by-step, readilyreproducible laboratory protocols, and tips on troubleshooting and avoidingknown pitfalls.Cutting edge and thorough, High Throughput Screening: Methods and Protocols,Third Edition, is a valuable resource for anyone who is interested in HTSresearch.
Название: High-Throughput Lead Optimization in Drug Discovery ISBN: 0367387719 ISBN-13(EAN): 9780367387716 Издательство: Taylor&Francis Рейтинг: Цена: 9798.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
A Single Source on Parallel Synthesis for Lead Optimization
The end of the previous millennium saw an explosion in the application of parallel synthesis techniques for making compounds for high-throughput screening. Over time, it became clear that more thought in the design phase of library development is necessary to generate high quality hits. More recently, the use of parallel synthesis techniques has shifted to applications beyond screening collections. Exploring the nuances of this technology, High-Throughput Lead Optimization in Drug Discovery describes the application of parallel synthesis to lead optimization and the design and synthesis of targeted libraries.
Examine Case Studies that Cover a Range of Different Biological Targets
Featuring real-world examples and contributions from well-known scientists, the book explores the shift to conducting parallel lead optimization in-house while outsourcing most of the screening libraries synthesis. It includes more than 15 case studies that encompass a range of biological targets for application in different therapeutic areas. The text contains examples of solid and solution-phase techniques for the synthesis of directed libraries. The chapter authors explain the design principles they used to direct the choice of templates and diversity elements.
Speed Up Drug Discovery and the Hit-to-Lead Process
Focusing on the application of combinatorial chemistry to medicinal chemistry, this volume compiles a series of optimization projects that give you a snapshot of successes and challenges in the use of parallel synthesis for lead optimization. It explores how this technology, when applied to library design, can speed up drug discovery.
Описание: High Throughput Formulation Development of Biopharmaceuticals: Practical Guide to Methods and Applications provides the latest developments and information on the science of stable and safe drug product formulations, presenting a comprehensive review and detailed description of modern methodologies in the field of formulation development, a process starting with candidate and pre-formulation screening in its early development phase and then progressing to the refinement of robust formulations during commercialization in the later phases of development. The title covers topics such as experiment design, automation of sample preparation and measurements, high-throughput analytics, stress-inducing methods, statistical analysis of large amounts of formulation study data, emerging technologies, and the presentation of several case studies, along with a concluding summary.
The development of suitable assays, the integration of appropriate technology, and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However, few scientists have the multidisciplinary experience needed to control all aspects of an HTS drug discovery project. A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery integrates the experience of diverse experts who offer fundamental and practical guidance across numerous situations.
The book first discusses assay developments for important target classes such as protein kinases and phosphatases, proteases, nuclear receptors, G protein-coupled receptors, ion channels, and heat shock proteins. It next examines assay developments for cell viability, apoptosis, and infectious diseases. The contributors explore the application of emerging technologies and systems, including image-based high content screening, RNA interference, and primary cells. Finally, they discuss the essential components of the integrated HTS process, such as screening automation, compound library management, the screening of natural products from botanical sources, and screening informatics.
Designed to motivate researchers to bring further advances to the field, this volume provides practical guidance on how to initiate, validate, optimize, and manage a bioassay intended to screen large collections of compounds. Drawing on the knowledge from experts actively involved in assay development and HTS, this is a resource that is both comprehensive and focused.
Автор: Bhunia, A K Название: High Throughput Screening for Food Safety Assessment ISBN: 0081013833 ISBN-13(EAN): 9780081013830 Издательство: Elsevier Science Рейтинг: Цена: 32002.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Recent advances in array-based detectors and imaging technologies have provided high throughput systems that can operate within a substantially reduced timeframe and other techniques that can detect multiple contaminants at one time. These technologies are revolutionary in terms of food safety assessment in manufacturing, and will also have a significant impact on areas such as public health and food defence. This book summarizes the latest research and applications of sensor technologies for online and high throughput screening of food. . . The book first introduces high throughput screening strategies and technology platforms, and discusses key issues in sample collection and preparation. The subsequent chapters are then grouped into four sections: Part I reviews biorecognition techniques; Part II covers the use of optical biosensors and hyperspectral imaging in food safety assessment; Part III focuses on electrochemical and mass-based transducers; and finally Part IV deals with the application of these safety assessment technologies in specific food products, including meat and poultry, seafood, fruits and vegetables.
Автор: Ingrid Walker Название: High: Drugs, Desire, and a Nation of Users ISBN: 0295742313 ISBN-13(EAN): 9780295742311 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 13794.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Whether drinking Red Bull, relieving chronic pain with oxycodone, or experimenting with Ecstasy, Americans participate in a culture of self-medication, using psychoactive substances to enhance or manage our moods. A “drug-free America” seems to be a fantasyland that most people don’t want to inhabit.
High: Drugs, Desire, and a Nation of Users asks fundamental questions about US drug policies and social norms. Why do we endorse the use of some drugs and criminalize others? Why do we accept the necessity of a doctor-prescribed opiate but not the same thing bought off the street? This divided approach shapes public policy, the justice system, research, social services, and health care. And despite the decades-old war on drugs, drug use remains relatively unchanged.
Ingrid Walker speaks to the silencing effects of both criminalization and medicalization, incorporating first-person narratives to show a wide variety of user experiences with drugs. By challenging current thinking about drugs and users, Walker calls for a next wave of drug policy reform in the United States, beginning with recognizing the full spectrum of drug use practices.
Описание: This thesis demonstrates a technology that enables pipetting-free high-throughput screening (HTS) on a miniaturized platform, eliminating the need for thousands of one-by-one pipetting and conventional liquid handling systems. This platform enhances accessibility to HTS and enables HTS to be used in small-to-medium scale laboratories. In addition, it allows large-scale combinatorial screening with a small number of valuable cells, such as patients’ primary cancer cells. This technique will have a high impact for widespread use of HTS in the era of personalized medicine.
In this thesis, the author firstly describes the need and concept of ‘partipetting’ for pipetting-free HTS platform. It is realized by the one-step pipetting and self-assembly of encoded drug-laden microparticles (DLPs) on the microwells. Next, the technical implementations required for the platform demonstration are described. It includes preparation of encoded DLPs, plastic chip fabrication, and realization of automated system. Lastly, screening of sequential drug combinations using this platform is demonstrated. This shows the potential of the proposed technology for various applications.
Автор: Walker Ingrid Название: High: Drugs, Desire, and a Nation of Users ISBN: 0295742321 ISBN-13(EAN): 9780295742328 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 3762.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Whether drinking Red Bull, relieving chronic pain with oxycodone, or experimenting with Ecstasy, Americans participate in a culture of self-medication, using psychoactive substances to enhance or manage our moods. A "drug-free America" seems to be a fantasyland that most people don't want to inhabit.
High: Drugs, Desire, and a Nation of Users asks fundamental questions about US drug policies and social norms. Why do we endorse the use of some drugs and criminalize others? Why do we accept the necessity of a doctor-prescribed opiate but not the same thing bought off the street? This divided approach shapes public policy, the justice system, research, social services, and health care. And despite the decades-old war on drugs, drug use remains relatively unchanged.
Ingrid Walker speaks to the silencing effects of both criminalization and medicalization, incorporating first-person narratives to show a wide variety of user experiences with drugs. By challenging current thinking about drugs and users, Walker calls for a next wave of drug policy reform in the United States, beginning with recognizing the full spectrum of drug use practices.
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