Автор: Karin ?llinger; Hanna Appelqvist Название: Lysosomes ISBN: 1493969323 ISBN-13(EAN): 9781493969326 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
1. SILAC-Based Comparative Proteomic Analysis of Lysosomes from Mammalian Cells Using LC-MS/MS Melanie Thelen, Dominic Winter, Thomas Braulke, and Volkmar Gieselmann
2. Quantitative Profiling of Lysosomal Lipidome by Shotgun Lipidomics Mesut Bilgin, Jesper Nylandsted, Marja Jддttelд, and Kenji Maeda
3. Analysis of N- And O-Glycosylation of Lysosomal Glycoproteins Elmira Tokhtaeva, Olga A. Mareninova, Anna S. Gukovskaya, and Olga Vagin
4. Analyzing Lysosome Related Organelles By Electron Microscopy Ilse Hurbain, Maryse Romao, Ptissam Bergam, Xavier Heiligenstein, And Graзa Raposo
5. Microscopic Analysis of Lysosomal Membrane Permeabilization Ana Maria Vilamill Giraldo, Karin Цllinger, and Vesa Loitto
6. Quantitative Co-localization and Pattern Analysis Of Endo-Lysosomal Cargo in Subcellular Image Cytometry and Validation on Synthetic Image Sets Frederik W. Lund and Daniel Wьstner
7. Preparation of a Two-Photon Fluorescent Probe for Imaging H2O2 in Lysosomes in Living Cells and Tissues Mingguang Ren, Beibei Deng, Xiuqi Kong, Yonghe Tang, and Weiying Lin
8. Lysophagy: A Method for Monitoring Lysosomal Rupture Followed by Autophagy Dependent Recovery Takanobu Otomo and Tamotsu Yoshimori
9. Delivery of Cargo to Lysosomes using Gneosomes Kristina M. Hamill, Ezequiel Wexselblatt, Wenyong Tong, Jeffrey D. Esko, and Yitzhak Tor
10. Lysosomal Acidification in Cultured Astrocytes Using Nanoparticles Camilla Lццv and Anna Erlandsson
11. Analysis of Lysosomal pH by Flow Cytometry Using FITC-dextran Loaded Cells Ida Eriksson, Karin Цllinger, and Hanna Appelqvist
12. Detection of Lysosomal Exocytosis in Platelets by Flow Cytometry Anna L. Sцdergren and Sofia Ramstrцm
13. Detection of Lysosomal Exocytosis by Surface Exposure of Lamp1 Luminal Epitopes Norma W. Andrews
14. Using the MEROPS Database for Investigation of Lysosomal Peptidases, their Inhibitors and Substrates Neil D. Rawlings
15. Next Generation Sequencing Approaches to Define the Role of the Autophagy Lysosomal Pathway in Human Disease: The Example of Lysoplex Giuseppina Di Fruscio, Sandro Banfi, Vincenzo Nigro, and Andrea Ballabio
16. Gelatin Zymography using Leupeptin for the Detection of Various Cathepsin L Forms Yoko Hashimoto
17. Methods for Determination of Α-Glycosidase, Β-Glycosidase, and Α-Galactosidase Activities in Dried Blood Spot Samples Eser Yıldırım Sozmen and Ebru Demirel Sezer
18. Prenatal Diagnosis of Lysosomal Storage Disorders Using Chorionic Villi Jyotsna Vermaa, Sunita Bijarnia-Mahaya, and Ishwar C. Vermaa
19. Lysosomal Biology in Cancer Colin Fennelly and Ravi Amaravadi
Описание: This book describes the development of novel protein–RNA-binding assays and their applications in a high-throughput manner for the identification of small-molecule modulators of protein–RNA interactions to treat cancer and COVID-19. Modulating protein–RNA interactions with small molecules is expected to provide novel biological insights of the interrelation of diseases with the protein–RNA interactome. The modulations may also be exploited therapeutically. For these reasons, the development of a simple, reliable, and sensitive protein–RNA-binding assay is necessary for high-throughput screening to discover new effective chemical entities capable of acting on diverse protein–RNA interactions. This book discusses the discovery of small-molecule modulators targeting protein–RNA interactions that are potentially valuable to treat cancer and COVID-19 by constructing novel high-throughput screening methods. The results of this dissertation provide valuable insights into the regulation of protein–RNA interactions in chemical biology and drug development.
Описание: Bridging biophysics and molecular imaging, this authoritative text guides readers through the use of single molecule approaches in the study of molecular nanomachines, protein folding, biological assemblies, gene expression, and DNA mapping for diagnostic purposes. A must-have for researchers, graduate students, and those working in the industry.
Автор: Owoeye, Olasupo Название: Ion and Molecule Transport in Lysosomes ISBN: 1032241152 ISBN-13(EAN): 9781032241159 Издательство: Taylor&Francis Рейтинг: Цена: 7348.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book discusses concepts and methods used to study lysosome ion and small molecule transport. The contents will not only attract accomplished investigators in need of a broad review and synthesis of this important subject but will also appeal to young investigators and trainees needing to acquire comprehensive knowledge and technical skills
Автор: Цllinger Karin, Appelqvist Hanna Название: Lysosomes: Methods and Protocols ISBN: 1493983431 ISBN-13(EAN): 9781493983438 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
1. SILAC-Based Comparative Proteomic Analysis of Lysosomes from Mammalian Cells Using LC-MS/MS Melanie Thelen, Dominic Winter, Thomas Braulke, and Volkmar Gieselmann
2. Quantitative Profiling of Lysosomal Lipidome by Shotgun Lipidomics Mesut Bilgin, Jesper Nylandsted, Marja Jддttelд, and Kenji Maeda
3. Analysis of N- And O-Glycosylation of Lysosomal Glycoproteins Elmira Tokhtaeva, Olga A. Mareninova, Anna S. Gukovskaya, and Olga Vagin
4. Analyzing Lysosome Related Organelles By Electron Microscopy Ilse Hurbain, Maryse Romao, Ptissam Bergam, Xavier Heiligenstein, And Graзa Raposo
5. Microscopic Analysis of Lysosomal Membrane Permeabilization Ana Maria Vilamill Giraldo, Karin Цllinger, and Vesa Loitto
6. Quantitative Co-localization and Pattern Analysis Of Endo-Lysosomal Cargo in Subcellular Image Cytometry and Validation on Synthetic Image Sets Frederik W. Lund and Daniel Wьstner
7. Preparation of a Two-Photon Fluorescent Probe for Imaging H2O2 in Lysosomes in Living Cells and Tissues Mingguang Ren, Beibei Deng, Xiuqi Kong, Yonghe Tang, and Weiying Lin
8. Lysophagy: A Method for Monitoring Lysosomal Rupture Followed by Autophagy Dependent Recovery Takanobu Otomo and Tamotsu Yoshimori
9. Delivery of Cargo to Lysosomes using Gneosomes Kristina M. Hamill, Ezequiel Wexselblatt, Wenyong Tong, Jeffrey D. Esko, and Yitzhak Tor
10. Lysosomal Acidification in Cultured Astrocytes Using Nanoparticles Camilla Lццv and Anna Erlandsson
11. Analysis of Lysosomal pH by Flow Cytometry Using FITC-dextran Loaded Cells Ida Eriksson, Karin Цllinger, and Hanna Appelqvist
12. Detection of Lysosomal Exocytosis in Platelets by Flow Cytometry Anna L. Sцdergren and Sofia Ramstrцm
13. Detection of Lysosomal Exocytosis by Surface Exposure of Lamp1 Luminal Epitopes Norma W. Andrews
14. Using the MEROPS Database for Investigation of Lysosomal Peptidases, their Inhibitors and Substrates Neil D. Rawlings
15. Next Generation Sequencing Approaches to Define the Role of the Autophagy Lysosomal Pathway in Human Disease: The Example of Lysoplex Giuseppina Di Fruscio, Sandro Banfi, Vincenzo Nigro, and Andrea Ballabio
16. Gelatin Zymography using Leupeptin for the Detection of Various Cathepsin L Forms Yoko Hashimoto
17. Methods for Determination of Α-Glycosidase, Β-Glycosidase, and Α-Galactosidase Activities in Dried Blood Spot Samples Eser Yıldırım Sozmen and Ebru Demirel Sezer
18. Prenatal Diagnosis of Lysosomal Storage Disorders Using Chorionic Villi Jyotsna Vermaa, Sunita Bijarnia-Mahaya, and Ishwar C. Vermaa
19. Lysosomal Biology in Cancer Colin Fennelly and Ravi Amaravadi
Автор: Paul Saftig Название: Lysosomes ISBN: 1441938044 ISBN-13(EAN): 9781441938046 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: It addresses the biogenesis of this compartment, the transport of lysosomal proteins, the role of the lysosomal membrane in lysosomal stability and transport, the function of lysosomal proteases and hydrolases, lysosomal storage disorders, and new concepts on how to treat these diseases.
Автор: Frances Platt Название: Lysosomes and lysosomal Diseases,126 ISBN: 0128000791 ISBN-13(EAN): 9780128000793 Издательство: Elsevier Science Рейтинг: Цена: 19875.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This new volume of Methods in Cell Biology looks at methods for lysosomes and lysosomal diseases. Chapters focus upon practical experimental protocols to guide researchers through the analysis of multiple aspects of lysosome biology and function. In addition, it details protocols relevant to clinical monitoring of patients with lysosomal diseases. With cutting-edge material, this comprehensive collection is intended to guide researchers for years to come.
Автор: E. Holtzman Название: Lysosomes: A Survey ISBN: 3709184118 ISBN-13(EAN): 9783709184110 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: , DE DUVE and WATTIAUX 1966; , September 1975 E. Perspectives 1 1. Definitions . General Functional Categories 2 1. Outline of Lysosome Functioning in Phagocytes 3 1. Characterization of Lysosomes . . . . . . . . . . The Lysosomal Enzymes . Cytochemical Methods . . . . . . . . . . Cytochemical Studies of Exogenous Tracers .
Автор: Eric Holtzman Название: Lysosomes ISBN: 0306429667 ISBN-13(EAN): 9780306429668 Издательство: Springer Рейтинг: Цена: 34799.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In 1976 I wrote a monograph on lysosomes (Lysosomes: A Survey, Springer- Verlag, Vienna) that was intended as an up-to-date, comprehensive survey. My goal here, therefore, is simply to introduce the major features of lysosomes at a level I hope will be useful both to I;ldvanced students and to researchers interested in obtaining a broad background.
Автор: Eric Holtzman Название: Lysosomes ISBN: 0306431262 ISBN-13(EAN): 9780306431265 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In 1976 I wrote a monograph on lysosomes (Lysosomes: A Survey, Springer- Verlag, Vienna) that was intended as an up-to-date, comprehensive survey. My goal here, therefore, is simply to introduce the major features of lysosomes at a level I hope will be useful both to I;ldvanced students and to researchers interested in obtaining a broad background.
Автор: Alexander E. Knight Название: Single Molecule Biology, ISBN: 0123742277 ISBN-13(EAN): 9780123742278 Издательство: Elsevier Science Рейтинг: Цена: 11789.00 р. Наличие на складе: Нет в наличии.
Описание: Describes such single molecule techniques (that allow for manipulation and measurement of single biological molecules within a live cell) as single molecule fluorescence, optical tweezers, and scanning probe microscopy. This book is organized by biological system or molecule. It discusses applications in molecular diagnostics and drug discovery.
This invaluable book provides the first description of the diverse and fascinating functions of heme in life processes for a broad audience. It begins with an introduction of the intricate chemical properties of heme and the history of early observations of human diseases associated with heme. It then proceeds to describe the versatile roles of heme in controlling diverse molecular and cellular processes germane to human life and disease processes. In the second edition, a new chapter is devoted to describe findings about heme uptake, transport, and trafficking of heme synthesis intermediates in mammals. Additionally, a chapter about the newly discovered roles of elevated heme biosynthesis and uptake in lung tumorigenesis is included.
Heme Biology is unified and logical in presentation. It is well suited for students and professionals in life sciences who wish to know about the fascinating biology of heme and its usefulness in health and diseases. It may also be used as a reference book for advanced readers and researchers who are interested in heme biology. The explanations in the book are detailed enough to capture the interest of the curious reader, and complete enough to provide the necessary information for researchers to have an in-depth molecular understanding of heme biology and further their studies in this fascinating realm.
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