Discovery of Small-Molecule Modulators of Protein–RNA Interactions for Treating Cancer and COVID-19, Byun
Автор: Mahesh Uttamchandani; Shao Q. Yao Название: Small Molecule Microarrays ISBN: 1493965824 ISBN-13(EAN): 9781493965823 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Small molecule microarrays (SMM) were introduced in 1999 and within just a short span of time, have established themselves as a vibrant next generation platform for high-throughput screening. Small Molecule Microarrays: Methods and Protocols consolidates a significant collection of examples, which serve to guide researchers toward ways in which SMM technology may be effectively deployed for multiplexed screening, drug discovery and ligand identification. The volume is organized into three sections covering microarray fabrication, imaging modes, and discovery approaches. The chapters cover a range of small molecule library types, ranging from synthetic combinatorial libraries to peptide and carbohydrate libraries, with lessons and techniques that can be widely applied. Written in the highly successful Methods in Molecular Biology series, format, chapters include introductions of their respective topics, lists of the requisite materials and reagents, step-by-step and readily reproducible laboratory protocols as well as vital tips on troubleshooting and advice on avoiding known pitfalls. Authoritative and cutting-edge, Small Molecule Microarrays: Methods and Protocols provides meticulous insights into the successful applications of SMM, by experts in the field. Building on this collection of knowledge, the volume seeks to inspire a future generation of microarray practitioners to propel this significant technology to even greater heights
Автор: Herbert Waldmann; Marcus Koppitz Название: Small Molecule — Protein Interactions ISBN: 3662053160 ISBN-13(EAN): 9783662053164 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Based on the international workshop on `Small Molecule - Protein Interactions` held in Berlin, April 24-26, 2002, researchers from industry and academic laboratories describe novel and efficient ways selecting promising new drug targets and developing small molecule inhibitors against them.
Автор: Sheng Название: Targeting Protein-Protein Interactions by Small Molecules ISBN: 9811307725 ISBN-13(EAN): 9789811307720 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book comprehensively reviews the state-of-the-art strategies developed for protein-protein interaction (PPI) inhibitors, and highlights the success stories in new drug discovery and development. Consisting of two parts with twelve chapters, it demonstrates the design strategies and case studies of small molecule PPI inhibitors. The first part discusses various discovery strategies for small molecule PPI inhibitors, such as high throughput screening, hot spot-based design, computational approaches, and fragment-based design. The second part presents recent advances in small molecule inhibitors, focusing on clinical candidates and new PPI targets. This book has broad appeal and is of significant interest to the pharmaceutical science and medicinal chemistry communities.
Описание: Illustrated throughout with successful case studies, this book provides a holistic, cutting-edge view of the subject area and is ideal for chemical biologists and medicinal chemists interested in developing PPI inhibitors.
Автор: Chunquan Sheng; Gunda I. Georg Название: Targeting Protein-Protein Interactions by Small Molecules ISBN: 9811344965 ISBN-13(EAN): 9789811344961 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book comprehensively reviews the state-of-the-art strategies developed for protein-protein interaction (PPI) inhibitors, and highlights the success stories in new drug discovery and development. Consisting of two parts with twelve chapters, it demonstrates the design strategies and case studies of small molecule PPI inhibitors. The first part discusses various discovery strategies for small molecule PPI inhibitors, such as high throughput screening, hot spot-based design, computational approaches, and fragment-based design. The second part presents recent advances in small molecule inhibitors, focusing on clinical candidates and new PPI targets. This book has broad appeal and is of significant interest to the pharmaceutical science and medicinal chemistry communities.
Описание: Inthis thesis single-molecule fluorescence resonance energy transfer(FRET)spectroscopy was used to study the folding of a protein that belongsto the large and important family of repeat proteins.
Описание: Inthis thesis single-molecule fluorescence resonance energy transfer(FRET)spectroscopy was used to study the folding of a protein that belongsto the large and important family of repeat proteins.
Автор: Chirlmin Joo; David Rueda Название: Biophysics of RNA-Protein Interactions ISBN: 1493997246 ISBN-13(EAN): 9781493997244 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: RNA molecules play key roles in all aspects of cellular life, but to do so efficiently, they must work in synergism with proteins. This book addresses how proteins and RNA interact to carry out biological functions such as protein synthesis, regulation of gene expression, genome defense, liquid phase separation and more.The topics addressed in this volume will appeal to researchers in biophysics, biochemistry and structural biology. The book is a useful resource for anybody interested in elucidating the molecular mechanisms and discrete properties of RNA-protein complexes. Included are reviews of key systems such as microRNA and CRISPR/Cas that exemplify how RNA and proteins work together to perform their biological function. Also covered are techniques ranging from single molecule fluorescence and force spectroscopy to crystallography, cryo-EM microscopy, and kinetic modeling.
Автор: Uttamchandani Mahesh, Yao Shao Q. Название: Small Molecule Microarrays: Methods and Protocols ISBN: 1493982427 ISBN-13(EAN): 9781493982424 Издательство: Springer Рейтинг: Цена: 13275.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
The Expanding World of Small Molecule Microarrays.- Novel Substrates for Microarrays.- Fabrication of Bio-function-preserved Saccharide Microarray Chips with Cyanuric Chloride as a Rotatable Linker.- Fabrication of Carbohydrate Microarrays by Boronate Formation.- Clickable Polymeric Coating for Glycan Microarrays.- A Versatile Microarray Immobilization Strategy Based on a Biorthogonal Reaction between Tetrazine and Trans-Cyclooctene.- Label-Free Sensing on Microarrays.- Optical Microscopy for Detecting Binding on Small Molecule Microarrays.- Array-on-array Strategy For Activity-based Enzyme Profiling.- Protein-Protein Interaction Inhibitors of BRCA1 Discovered Using Small Molecule Microarrays.- Discovery of RNA Binding Small Molecules Using Small Molecule Microarrays.- Profiling Phosphopeptide-binding Domain Recognition Specificity using Peptide Microarrays.- Validation Procedure for Multiplex Antibiotic Immunoassays Using Flow-based Chemiluminescence Microarrays.- Large-scale Interaction Profiling of Protein Domains through Proteomic Peptide-PhageDisplay using Custom Peptidomes.- Synthetic Glycan Microarrays.- Screening Mammalian Cells on a Hydrogel- Functionalized Small Molecule Microarray.
Автор: Mahesh Uttamchandani; Shao Q. Yao Название: Small Molecule Microarrays ISBN: 1493958151 ISBN-13(EAN): 9781493958153 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Small molecule microarrays (SMM) were introduced just a decade ago in 1999 and, within a short space of time, have already established themselves as a vibrant, next generation platform for high-throughput screening. Small Molecule Microarrays: Methods and Protocols showcases a collection of contributions guiding researchers toward ways in which small molecule microarray technology may be deployed for multiplexed screening and profiling. Organized by the categories of small molecules presented on the microarrays, this detailed volume describes in-depth techniques for chemical libraries, peptide libraries, and carbohydrate microarrays. Written in the highly successful Methods in Molecular Biology™ series, chapters contain brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, vital tips on troubleshooting this often difficult technology, and advice on avoiding known pitfalls. Authoritative and cutting-edge, Small Molecule Microarrays: Methods and Protocols provides meticulous depictions of key hands-on experience and seeks to inspire a future generation of microarray practitioners to take this significant technology forward.
Автор: Sylvain Celanire; Sonia Poli Название: Small Molecule Therapeutics for Schizophrenia ISBN: 3319115014 ISBN-13(EAN): 9783319115016 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Antipsychotics and the Dopamine-Serotonin Connection.- GLYT1 Inhibitors: From Hits to Clinical Candidates.- Metabotropic Glutamate Receptor 2 Activators.- Activation of the mGlu5 Receptor for the Treatment of Schizophrenia and Cognitive-Deficit-Associated Disorders.- Muscarinic Acetylcholine Receptor Activators.- Nicotinic Acetylcholine Receptor Modulators.- The Use of PDE10A and PDE9 Inhibitors for Treating Schizophrenia.
Автор: Sylvain Celanire; Sonia Poli Название: Small Molecule Therapeutics for Schizophrenia ISBN: 3319378945 ISBN-13(EAN): 9783319378947 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drug ability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine.
ООО "Логосфера " Тел:+7(495) 980-12-10 www.logobook.ru
