Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease reviews how the different aspects of metabolic dysfunction and consequent pathology associated with neurodegenerative diseases, including Alzheimer's and Parkinson's, can be targeted by novel treatment approaches. Topics covered include Cellular Senescence in Aging and Age-Related Disorders: Implications for Neurodegenerative Diseases; Repurposing GLP1 agonists for Neurodegenerative Diseases; Ketotherapeutics for Neurodegenerative Diseases; Enhancing Mitophagy as a Therapeutic Approach for Neurodegenerative Diseases; Harnessing Neurogenesis in the Adult Brain - A Role in Type 2 Diabetes Mellitus and Alzheimer's disease; and much more.
Автор: Paul R. Sanberg; Hitoo Nishino; Cesario V. Borlong Название: Mitochondrial Inhibitors and Neurodegenerative Disorders ISBN: 1468498215 ISBN-13(EAN): 9781468498219 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Believed to be the remnants of bacterial infection of eukaryotic cells eons ago, the mitochondrion evolved a symbiotic relationship in which it dutifully served as the efficient source of A TP for cell function.
Автор: Verkhratsky Alexei, Ho Margaret S., Zorec Robert Название: Neuroglia in Neurodegenerative Diseases ISBN: 9811399158 ISBN-13(EAN): 9789811399152 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides a comprehensive overview of the role of neuroglia in neurodegenerative diseases. In addition, to highlight the function of neuroglia in different types of neurodegenerative disease, it also discusses their mechanisms and effects on protecting or damaging neurons.
Автор: Michael J. Hurley Название: Omic Studies of Neurodegenerative Disease - Part B,122 ISBN: 0128047623 ISBN-13(EAN): 9780128047620 Издательство: Elsevier Science Рейтинг: Цена: 24423.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Omic Studies of Neurodegenerative Disease: Part B is part of a well-established international series on neuroscience that examines major areas of basic and clinical research, along with emerging and promising subfields.
The book informs the reader on the current state of the studies used to evaluate the mechanisms, causes, and treatment of neurodegeneration through a combination of literature reviews and examples of current research.
Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease summarizes recent developments in intervention trials in neurodegenerative diseases, particularly Alzheimer's and Parkinson's, as well as increasing evidence for the overlap between drivers of metabolic and neurodegenerative disease that impact mitochondrial function and bioenergetics, and subsequently cellular function and pathophysiology. Topics covered include Brain Glucose and Ketone Utilization in Brain Ageing and Neurodegenerative Diseases; the Mitochondrial Hypothesis: Dysfunction, Bioenergetic Defects, and the Metabolic Link to Alzheimer's Disease; the Metabolic Impact on Neuroinflammation and Microglial Modulation in Neurodegenerative Diseases, the Impact of Circadian and Diurnal Rhythms on Cellular Metabolic Function and Neurodegenerative Diseases, and much more.
Summarizes the current status of and future research in Alzheimer's and Parkinson's diseases
Reviews the impact of the metabolic hypothesis on underlying mechanisms of neurodegenerative diseases.
Описание: Multiple advanced neuroimaging applications in various neurodegenerative diseases including Parkinsons disease (PD), frontotemporal dementia (FTD), vascular dementia (VaD) and autism spectrum disorder (ASD) are covered in this book. Relatively novel techniques such as integrated PET/MRI and independent component analysis (ICA)-based dual regression (DR) methods were developed to capture multi-level molecular/functional and structural/microstructural as well as high-order inter-network coordination abnormalities. For instance, both PET dopamine transporter and striatal binding ratio reductions in the caudate and putamen were found in PD, consistent with the diffusion tensor imaging (DTI) fractional anisotropy (FA) reduction and fMRI voxel-mirrored homotopic correlation (VMHC) in the substantia nigra (swallow tail sign signature of PD). Furthermore, dopamine storage and pathway labeled with the vesicular monoamine transporter tracer identified decreased densities in the bilateral mesial temporal cortex, caudate, orbitofrontal cortex, left frontal and occipital cortices, consistent with the morphological atrophy, functional connectivity and conductivity deficits in PD. Similarly in FTD patients, the advanced MRI methods such as ICA-DR, VMHC, voxel-based morphometry (VBM) as well as PET tracer for amyloid accumulation and FDG glucose uptake identified typical brain atrophy, structural dis-connectivity, glucose hypometabolism, higher neuropathological burden, lower interhemispheric correlation as well as disrupted intra- and inter-network modulation in the orbitofrontal and anterior temporal cortices together with insular and frontoparietal networks, with the cerebellum and dorsolateral attentional network as typical compensations. Functional and structural abnormalities had further been elucidated in the VaD dependent participants and autistic children. For instance, both lower FA and VMHC, brain atrophy and functional connectivity deficits, demyelination, axonal degeneration and white matter integrity damage in several white matter tracts were present in the dependent compared to independent participants in VaD data cohort. Increased neuronal activity with higher global fractional amplitude of low frequency fluctuation (fALFF) in the conventional and slow-wave sub-band was confirmed with less efficiency of systematic integration in VaD dependent group. Moreover, in ASD compared to controls, regional gray matter volume and cortical thickness in all four brain lobes increased, whereas white matter volume were decreased in addition to the lower temporal, visual and superior frontal but higher inferior and dorsolateral prefrontal cortical functional connectivities exhibited in ASD. The differences in each type of disease could also be revealed with the same imaging method based on either unique region or distinct brain circuit inter-connection, using VMHC, ICA-DR, DTI, VBM, fALFF and graph-theory based small-worldness analysis. In this book, we have developed and generalized conventional and advanced imaging methodologies to several common neurodegenerative diseases. For instance, we have identified the unique imaging signature for each disease type and the underlying neuropathological mechanism connections with conductivity, structural and microstructural connectivity, intra- and inter-network correlation, systematic integration and efficiency analyses. Our objective, comprehensive and confirmative results indicated great potential in utilizing these quantifications for accurate disease classification and staging. With solid imaging evidence, thorough analysis and generalized applications, this book should capture the interests of readers in the broad fields of brain science, disease diagnosis and effective treatment.
Автор: Yongxia Zhou Название: Multiparametric Imaging in Neurodegenerative Disease ISBN: 1536153389 ISBN-13(EAN): 9781536153385 Издательство: Nova Science Рейтинг: Цена: 22491.00 р. Наличие на складе: Невозможна поставка.
Описание: Neuroimaging techniques that can help elucidate and characterize the nature and mechanism of tissue injury and disease progression in neurodegenerative disease are of particular importance given its their roles in seeking successful preventive and therapeutic treatments. Studying large-scale samples with various disease mechanisms using multi-parametric imaging, as well as revealing the correlations between the neuroimaging metrics and clinical data including neurocognitive function and neuropsychological inventories to elucidate multiple factors affecting the neurodegeneration processes in brain are the main topics of this book. In addition, the neural underpins of cognitive and psychological functions with advanced functional imaging techniques can provide better cross-validation and clinical symptom relevance of multi-parametric data. Expanding the current findings with higher diagnosis accuracy and detection specificity in multiple neurodegenerative diseases as well as better differentiation of each type are the ultimate goal. The results in this book will extend the current notion of diagnosis value of various relatively new imaging techniques in multiple neurodegenerative diseases including traumatic brain injury, post-traumatic stress disorder, multiple sclerosis and early stage of Alzheimers disease such as mild cognitive impairment. Specifically, the neurobiology and related imaging findings of the four representative neurodegenerative diseases will be introduced and reviewed, including brain region-specific and disease-related alterations, unique clinical symptom of each disease, as well as previous findings and challenges. There is an increasing body of literature suggesting that damage to the default mode network, hypothalamus, thalamus and hippocampus neuronal networks and local injuries might be under-diagnosed and may account for some of the sequelae following the neurodegenerative injuries including trauma and dementia. The relatively novel imaging results to differentiate each disease using advanced functional connectivity, neuronal activity, microstructure integrity analysis based on structural connectivity, multi-dimensional morphometry and molecular imaging tracers including amyloid and tau for neuropathological burden quantification were presented to differentiate each type of disease. We then briefly reviewed some of the therapeutic effects of traditional Chinese medicine with neuroimaging quantifications to help treating neurodegenerative diseases. Finally, our work proves that the multi-parametric neuroimaging methods with more than twelve metrics and numerous tight clinical association data presented in this book are the most forefront and up-to-date with enough sensitivity, precision and resolution. Taken together, multiple neuroimaging metrics haved been demonstrated in this book to identify and quantify significant and distinct brain alterations at function, microstructure, morphology and molecular scales in different types of neurodegenerative diseases with high sensitivity and specificity. These comprehensive imaging features could be combined to improve disease diagnosis accuracy. The aim of this book is thus intended to provide both beginners and experts in biomedical imaging and health care a broad and complete picture as well as the new developments of using multiple metrics in improving disease identification and diagnosis accuracy. This book would hopefully capture the interests of colleagues interested in neurodegenerative disease diagnosis and treatment, and could help convey the methodological and integrative perspectives of multi-parametric neuroimaging applications.
Автор: Baekelandt, Veerle Название: Disease-Modifying Targets in Neurodegenerative Disorders ISBN: 0128051205 ISBN-13(EAN): 9780128051207 Издательство: Elsevier Science Рейтинг: Цена: 11706.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies.
This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment.
Provides a comprehensive overview of how key proteins in neurodegenerative disorders can be used as targets to modify disease progress
Summarizes how patients are treated today, providing a glance at future disease management
Includes intelligible and informative information that is perfect for non-specialists, medical practitioners, and scientists
Written and peer reviewed by outstanding scientists in their respective fields
Описание: Recent advances in understanding the role of protein dysmetabolism in neurodegeneration was the theme of the Fondation IPSEN meeting addressing Genotype-Proteotype-Phenotype relationships.
Автор: Verkhratsky Название: Neuroglia in Neurodegenerative Diseases ISBN: 9811399123 ISBN-13(EAN): 9789811399121 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides a comprehensive overview of the role of neuroglia in neurodegenerative diseases. Neuroglia are the most abundant cells in the nervous system and consist of several distinct cell types, such as astrocytes, oligodendrocytes,and microglia. Accumulating evidence suggests that neuroglia participate in the neurodegenerative process, and as such are essential players in a variety of diseases, including Alzheimer’s, Parkinson’s, and Huntington’s. Intended for researchers and students, the book presents recent advances concerning the biology of neuroglia as well as their interaction with neurons during disease progression. In addition, to highlight the function of neuroglia in different types of neurodegenerative disease, it also discusses their mechanisms and effects on protecting or damaging neurons.
Автор: Wada Keiji Название: Neurodegenerative Disorders as Systemic Diseases ISBN: 4431562982 ISBN-13(EAN): 9784431562986 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book sheds new light on neurodegenerative disorders as systemic diseases. Classically, neuronal cell death was a hallmark of such disorders. However, it has become evident that neural dysfunction is more important in the pathophysiology of neurodegenerative disorders. More recently, the prionoid-spreading hypothesis of disease-causing molecules has attracted a great deal of attention. Therapeutic strategies thus must be reconsidered in the light that neurodegenerative disorders are indeed systemic diseases. The first part of this book introduces the concept of neurodegeneration in biology and pathophysiology. The second part focuses on clinical evaluation and biomarkers from the perspective of this new concept, while the third summarizes the risk factors of neurodegeneration. The fourth part of this work indicates future directions of treatment, and the final part discusses health promotion for prevention and quality of life. This book will be of interest to both researchers and medical personnel, and provides a fresh approach to neurodegenerative diseases, paving the way to new research and improved quality of health care for patients.
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