Metabolic And Bioenergetic Drivers Of Neurodegenerative Disease: Treating Neurodegenerative Diseases As Metabolic Diseases,155, Soderbom, Grazyna
Автор: Weissbrod Название: Neurologic and Neurodegenerative Diseases of the Larynx ISBN: 303028851X ISBN-13(EAN): 9783030288518 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Researchers seeking problems that offer more hope of success often avoid subjects that seem to be difficult to approach experimentally, or subjects for which experimental results are difficult to interpret.
Автор: Sattler Название: RNA Metabolism in Neurodegenerative Diseases ISBN: 3319896881 ISBN-13(EAN): 9783319896885 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book targets various diseases, such as Alzheimer's disease, frontotemporal dementia and various tauopathies. It also provides a profound explanation of various neurodegenerative diseases with novel theories of understanding the etiology, pathological
Автор: Verkhratsky Название: Neuroglia in Neurodegenerative Diseases ISBN: 9811399123 ISBN-13(EAN): 9789811399121 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides a comprehensive overview of the role of neuroglia in neurodegenerative diseases. Neuroglia are the most abundant cells in the nervous system and consist of several distinct cell types, such as astrocytes, oligodendrocytes,and microglia. Accumulating evidence suggests that neuroglia participate in the neurodegenerative process, and as such are essential players in a variety of diseases, including Alzheimer’s, Parkinson’s, and Huntington’s. Intended for researchers and students, the book presents recent advances concerning the biology of neuroglia as well as their interaction with neurons during disease progression. In addition, to highlight the function of neuroglia in different types of neurodegenerative disease, it also discusses their mechanisms and effects on protecting or damaging neurons.
Автор: Marie-Francoise Chesselet Название: Molecular Mechanisms of Neurodegenerative Diseases ISBN: 1617371971 ISBN-13(EAN): 9781617371974 Издательство: Springer Рейтинг: Цена: 34799.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The field ofneurodegenerative diseases is undergoing an unprecedented revolution. The past decade has seen the identification of new mutation mecha- nisms, such as triplet repeat expansions, and new genes causing familial forms of common neurodegenerative diseases, such as Parkinson's and Alzheimer's diseases. Cellular and animal models based on this genetic information are now available and, importantly, common mechanisms are rapidly emerging among diseases that were once considered unrelated. The field is poised for the development of new therapies based on high throughput screenings and a bet- ter understanding of the molecular and cellular mechanisms leading to neurodegeneration. Molecular Mechanisms of Neurodegenerative Diseases reviews recent progress in this exploding field. By nature, such a book cannot be all inclu- sive. It focuses on Alzheimer's, Parkinson's, and CAG triplet repeat diseases. In the first chapter, Bill Klein reviews the role of A toxicity in the patho- physiology of Alzheimer's disease. This controversial issue is further exam- ined in the context of transgenic models of Alzheimer's disease by LaFerla and colleagues. Sue Griffin and Robert Mrak, and Caleb Finch and collabora- tors, then examine the role of glial cells and inflammation in Alzheimer's disease; a review of the role of proteolysis in the generation of abnormal pro- tein fragments by Hook and Mende-Mueller follows. Therapeutic opportuni- ties offered by a better understanding of Alzheimer's disease pathophysiology are examined by Perry Molinoff and his colleagues at Bristol-Myers Squibb.
Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease summarizes recent developments in intervention trials in neurodegenerative diseases, particularly Alzheimer's and Parkinson's, as well as increasing evidence for the overlap between drivers of metabolic and neurodegenerative disease that impact mitochondrial function and bioenergetics, and subsequently cellular function and pathophysiology. Topics covered include Brain Glucose and Ketone Utilization in Brain Ageing and Neurodegenerative Diseases; the Mitochondrial Hypothesis: Dysfunction, Bioenergetic Defects, and the Metabolic Link to Alzheimer's Disease; the Metabolic Impact on Neuroinflammation and Microglial Modulation in Neurodegenerative Diseases, the Impact of Circadian and Diurnal Rhythms on Cellular Metabolic Function and Neurodegenerative Diseases, and much more.
Summarizes the current status of and future research in Alzheimer's and Parkinson's diseases
Reviews the impact of the metabolic hypothesis on underlying mechanisms of neurodegenerative diseases.
Описание: The mechanisms of neurodegenerative diseases are elucidated in this book. It throws light on the pathophysiological complexities of the mechanisms and factors that are most probably involved in a number of neurodegenerative and neuroinflammatory diseases
Описание: This book examines generic mechanisms in neurodegenerative diseases. It throws light on the pathophysiological complexities of the mechanisms and factors that are most probably involved in a number of neurodegenerative and neuroinflammatory diseases inclu
Автор: Gary Fiskum Название: Neurodegenerative Diseases ISBN: 0306452987 ISBN-13(EAN): 9780306452987 Издательство: Springer Рейтинг: Цена: 30039.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the Fifteenth Washington International Spring Symposium held at The George Washington University, Washington, D.C., May 15-17, 1995
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