The Neuroscience Of Parkinson`S Disease, Martin, Colin R.
Автор: Haines Duane E. Название: Fundamental Neuroscience for Basic and Clinical Applications ISBN: 0323396321 ISBN-13(EAN): 9780323396325 Издательство: Elsevier Science Рейтинг: Цена: 12968.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Using a rigorous yet clinically-focused approach, Fundamental Neuroscience for Basic and Clinical Applications, 5th Edition, covers the fundamental neuroscience information needed for coursework, exams, and beyond. It integrates neuroanatomy, pharmacology, and physiology, and offers a full section devoted to systems neurobiology, helping you comprehend and retain the complex material you need to know.
Highlights clinical content in blue
throughout the text, helping you focus on what you need to know in the clinical environment.
Presents thoroughly updated information in every chapter, with an emphasis on new clinical thinking as related to the brain and systems neurobiology.
Features hundreds of correlated state-of-the-art imaging examples, anatomical diagrams, and histology photos - nearly half are new or improved for this edition.
Pays special attention to the correct use of clinical and anatomical terminology, and provides new clinical text and clinical-anatomical correlations.
Автор: Dale Purves et all, editors Название: Neuroscience ISBN: 160535841X ISBN-13(EAN): 9781605358413 Издательство: Oxford Academ Рейтинг: Цена: 28827.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: For over 25 years, Purves Neuroscience has been the most comprehensive and clearly written neuroscience textbook on the market. This level of excellence continues in the 6th Edition, with a balance of animal, human, and clinical studies that discuss the dynamic field of neuroscience from cellular signaling to cognitive function.
Автор: Derreumaux Philippe Название: Alzheimer`s Disease: Insights into Low Molecular Weight and ISBN: 1848167547 ISBN-13(EAN): 9781848167544 Издательство: World Scientific Publishing Рейтинг: Цена: 22968.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Alzheimer`s disease is the most common form of senile dementia, affecting more than 24 million people worldwide. This book provides a panoramic view across in vitro and in vivo studies along with computer simulations, designed to increase the readers` understanding of oligomerisation and fibril formation.
Автор: Abraham Fisher; Maurizio Memo; Fabrizio Stocchi; I Название: Advances in Alzheimer`s and Parkinson`s Disease ISBN: 1441944230 ISBN-13(EAN): 9781441944238 Издательство: Springer Рейтинг: Цена: 43184.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume contains the proceedings of the 2005 ADPD conference and is unique in that it deals not only with issues related individually to Alzheimer`s disease and Parkinson`s disease, but also with the integration of these and other related diseases.
Автор: Verstreken, Patrik Название: Parkinson`s Disease ISBN: 0128037830 ISBN-13(EAN): 9780128037836 Издательство: Elsevier Science Рейтинг: Цена: 11193.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Parkinson’s Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson’s disease, the second most common neurodegenerative disease, and the most common movement disorder. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson's pathology. . This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different causative genes.Readers will find descriptions of model systems that present parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms. Written from both a cross-methodology and cross-species perspective, the book provides readers with the current state of knowledge on the molecular biology of Parkinson’s.
Описание: This volume brings together various theories of how aberrations in mitochondrial function and morphology contribute to neurodegeneration in idiopathic and familial forms of Parkinson’s disease. Moreover, it comprehensively reviews the current search for therapies, and proposes how molecules are involved in specific functions as attractive therapeutic targets. It is expected to facilitate critical thought and discussion about the fundamental aspects of neurodegeneration in Parkinson’s disease and foster the development of therapeutic strategies among researchers and graduate students. Theories of idiopathic Parkinson’s etiology support roles for chronic inflammation and exposure to heavy metals or pesticides. Interestingly, as this project proposes, a case can be made that abnormalities in mitochondrial morphology and function are at the core of each of these theories. In fact, the most common approach to the generation of animal and cell-culture models of idiopathic Parkinson’s disease involves exposure to mitochondrial toxins. Even more compelling is the fact that most familial patients harbor genetic mutations that cause disruptions in normal mitochondrial morphology and function. While there remains to be no effective treatment for Parkinson’s disease, efforts to postpone, prevent and “cure” onset mitochondrial aberrations and neurodegeneration associated with Parkinson’s disease in various models are encouraging. While only about ten percent of Parkinson’s patients inherit disease-causing mutations, discovering common mechanisms by which familial forms of Parkinson’s disease manifest will likely shed light on the pathophysiology of the more common idiopathic form and provide insight to the general process of neurodegeneration, thus revealing therapeutic targets that will become more and more accessible as technology improves.
Mathematical Modelling in Motor Neuroscience: State of the Art and Translation to the Clinic, Gaze Orienting Mechanisms and Disease, Volume 249, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Sequential Bayesian updating, Maps and Sensorimotor Transformations for Eye-Head Gaze Shifts: Role of the Midbrain Superior Colliculus, Modeling Gaze Position-Dependent Opsoclonus, Eye Position-Dependent Opsoclonus in Mild Traumatic Brain Injury, Saccades in Parkinson's disease -- hypometric, slow, and maladaptive, Brainstem Neural Circuits for Fixation and Generation of Saccadic Eye Movements, and much more.
Автор: Ronald F. Pfeiffer Название: Parkinson`s Disease, Second Edition ISBN: 1439807140 ISBN-13(EAN): 9781439807149 Издательство: Taylor&Francis Рейтинг: Цена: 32155.00 р. Наличие на складе: Поставка под заказ.
Описание: In recent years, considerable advances have been made in our knowledge and understanding of Parkinson's disease (PD). In particular, there has been an explosion of information regarding genetic contributions to the etiology of PD and an increased awareness of the incidence and importance of the non-motor features of the disease. Theories regarding the pathogenesis and pathophysiology of PD have also been refined, and new treatment modalities and advances have been implemented. Reflecting these changes, this second edition features new chapters devoted to genetic aspects of PD, non-motor features of the disease, as well as aspects of the pathophysiology, pathogenesis, and treatment of PD.
Автор: Shetty Ashok K. Название: Neural Stem Cells in Health and Disease ISBN: 9814623172 ISBN-13(EAN): 9789814623179 Издательство: World Scientific Publishing Рейтинг: Цена: 15523.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is a comprehensive guide on neural stem cell behavior in health and disease.
Автор: Mayhan William G. Название: Blood-Brain Barrier in Health and Disease ISBN: 1615047395 ISBN-13(EAN): 9781615047390 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 5016.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The blood-brain barrier (BBB) is a complex and dynamic structure that protects the brain from cells within the vasculature, from the immune system and from pathogens. This barrier is present in arterioles, capillaries and venules and is formed at the level of adjacent endothelial cells, which are coupled to astrocytes, microglia, neurons and pericytes. The structure of this endothelial barrier is unique among endothelia of other organ systems and is composed of complexes made up of tight, gap and adherens junctions. In addition, it is the responsibility of the surrounding cellular elements to maintain the integrity of the junctional complexes and restrict the entry of substances from the blood into the brain. Changes in permeability of the BBB during physiologic and pathophysiologic conditions involve alterations in specific transporters at the level of the endothelium, activation of specific cellular second messenger pathways and/or the dissolution of the junctional complexes composing the BBB. This book focuses on various aspects that account for the formation and maintenance of the BBB, and on disease states that compromise this barrier.
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