This book compiles recent research on the modification of nucleic acids. It covers backbone modifications and conjugation of lipids, peptides and proteins to oligonucleotides and their therapeutic use. Synthesis and application in biomedicine and nanotechnology of aptamers, fluorescent and xeno nucleic acids, DNA repair and artificial DNA are discussed as well.
Автор: Michael G. Sargent Название: Biomedicine and the Human Condition ISBN: 0521541484 ISBN-13(EAN): 9780521541480 Издательство: Cambridge Academ Рейтинг: Цена: 8394.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: How to avoid disease, how to breed successfully, and how to live to a reasonable age are questions that have long perplexed humankind. This 2005 book explores our progress in understanding these challenges, and the risks and rewards of our attempts to find solutions.
Автор: Van Delft Floris, Lambert John M. Название: Chemical Linkers in Antibody-Drug Conjugates (Adcs) ISBN: 1839162635 ISBN-13(EAN): 9781839162633 Издательство: Royal Society of Chemistry Рейтинг: Цена: 45923.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Chemical Linkers in Antibody-Drug Conjugates aims to shine a detailed light on the various key attributes of chemical linkers in ADCs, for drug-to-antibody ratio, for stability, for release mechanism of payload, for pharmacokinetics, for stability determination, and for efficacy and safety.
Автор: Ulf Grawunder; Stefan Barth Название: Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins ISBN: 3319468758 ISBN-13(EAN): 9783319468754 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities.
The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.
Описание: The rapid developments in nanostructured materials and nanotechnology will have a profound impact in many areas of biomedical applications including delivery of drugs and biomolecules, tissue engineering, detection of biomarkers, cancer diagnosis, cancer therapy, and imaging. This field is expanding fast, and a lot of work is in progress in terms of design, characterization, synthesis, and application of materials, for controlling shape and size at nanometer scale to develop highly advanced materials for biomedical application and even to design better pharmaceutical products. In recent years, specific attempts have been made to acquire multi-functional nanostructures that could possibly solve the plethora of issues and voids often encountered in both medicinal and biological researches. This book, comprising six chapters, emphasizes the practical implementation of few well-known as well as advanced nanostructured materials for the betterment of human health and diagnostic tools. Each chapter emphasizes a single aspect of the nanostructures in broader context, providing a brief history, current status, and emerging trends in the same field. In Chapter 1, authors have provided a detailed account of the implementation of nanostructures in the sensing of several key biomolecules, which can detect the well-being of both internal and external structures of the human body. Chapter 2 presents a brief analysis of the current therapeutics focusing on their viability and shortcomings, and addressing the same through the implementation of nanotechnology. Chapter 3 encompasses the challenges in the field of cell-imaging and detection of biomarkers. Authors have provided a vivid explanation regarding the solution of such challenges through designing and functionalization of several metallic nanoparticles including quantum dots. In Chapter 4, a brief account of the application of nanostructures in the area of tissue engineering and magnetic resonance imaging has been discussed. In Chapter 5, nanomedicines have been introduced by the authors as an advanced diagnostic and therapeutic option as compared to the traditionally available solutions for oral cancer treatment. Finally, Chapter 6 discusses the application of nanotechnology (both organic and inorganic nanoparticles) in restorative dentistry. Also, possible biocompatibility and toxicity of the nanostructures have been discussed so as to streamline the process of selection of suitable tooth implants and oral cleansing techniques.
Автор: Damelin Marc Название: Innovations for Next-Generation Antibody-Drug Conjugates ISBN: 3319781537 ISBN-13(EAN): 9783319781532 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.
Автор: Helmut Schlaad Название: Bio-synthetic Polymer Conjugates ISBN: 3642445071 ISBN-13(EAN): 9783642445071 Издательство: Springer Рейтинг: Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Polypeptide-Polymer Conjugates, by Henning Menzel Chemical Strategies for the Synthesis of Protein-Polymer Conjugates, by Bjorn Jung and Patrick Theato Glycopolymer Conjugates, by Ahmed M.
Автор: Marc Damelin Название: Innovations for Next-Generation Antibody-Drug Conjugates ISBN: 3030086275 ISBN-13(EAN): 9783030086275 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.
Описание: As a paradigm for the future, micro-scale technology seeks to fuse revolutionary concepts in science and engineering and then translate it into reality. Nanotechnology is an interdisciplinary field that aims to connect what is seen with the naked eye and what is unseen on the molecular level.Diverse Applications of Nanotechnology in Biomedicine, Chemistry, and Engineering examines the strengths and future potential of micro-scale technologies in a variety of industries. Highlighting the benefits, shortcomings, and emerging perspectives in the application of nano-scale technologies, this book is a comprehensive reference source for synthetic chemists, engineers, graduate students, and researchers with an interest in the multidisciplinary applications, as well as the ongoing research in the field.
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