An Essential Guide to Antimicrobial Agents, Ernesto Macias
Автор: Bueno Juan Название: Preclinical Evaluation of Antimicrobial Nanodrugs ISBN: 3030438546 ISBN-13(EAN): 9783030438548 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Translational medicine addresses the gap between research and the clinical application of new discoveries. To efficiently deliver new drugs to care centers, a preclinical evaluation, both in vitro and in vivo, is required to ensure that the most active and least toxic compounds are selected as well as to predict clinical outcome. Antimicrobial nanomedicines have been shown to have higher specificity in their therapeutic targets and the ability to serve as adjuvants, increasing the effectiveness of pre-existing immune compounds. The design and development of new standardized protocols for evaluating antimicrobial nanomedicines is needed for both the industry and clinical laboratory. These protocols must aim to evaluate laboratory activity and present models of pharmacokinetic-pharmacodynamic and toxicokinetic behavior that predict absorption and distribution. Likewise, these protocols must follow a theranostics approach, be able to detect promising formulations, diagnose the infectious disease, and determine the correct treatment to implement a personalized therapeutic behavior. Given the possibilities that nanotechnology offers, not updating to new screening platforms is inadequate as it prevents the correct application of discoveries, increasing the effect of the valley of death between innovations and their use. This book is structured to discuss the fundamentals taken into account for the design of robust, reproducible and automatable evaluation platforms. These vital platforms should enable the discovery of new medicines with which to face antimicrobial resistance (RAM), one of the great problems of our time.
Автор: Bruno Oliveira de Veras Название: Antimicrobial Potential of Essential Oils ISBN: 1536169455 ISBN-13(EAN): 9781536169454 Издательство: Nova Science Рейтинг: Цена: 13462.00 р. Наличие на складе: Невозможна поставка.
Описание: Instead of relying on prescription medications with numerous dangerous side effects, what if you could opt for a safer, natural alternative to address your health concerns? Medicinal plants for therapeutic purposes have been used for many years. The antimicrobial activity of essential oils and their major constituents has been widely documented by several works, however, in a fragmented way. Based on this premise, this book is designed to provide an overview of current knowledge about the antimicrobial properties of essential oils and their mechanisms of action, either alone or in combination, as a possible tool for obtaining new antibiotics.
Описание: Offers many antibiotics and antimicrobial compounds: in development, experimental, and in use. This title covers chemistry and synthesis, classification, structure-activity relationships, mechanisms of action and resistance, breakpoints, in vitro/in vivo activities, epidemiology, pharmacokinetics, metabolism, and adverse events.
Автор: J. F. Snell; J. W. Corcoran; K. L. Arora; F. E. Ha Название: Mechanism of Action of Antimicrobial and Antitumor Agents ISBN: 3642463061 ISBN-13(EAN): 9783642463068 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume is the third in the series devoted to Antibiotics initiated by Springer Verlag in 1967.
Автор: Jean-Michel M?rillon; C?line Riviere Название: Natural Antimicrobial Agents ISBN: 3030097862 ISBN-13(EAN): 9783030097868 Издательство: Springer Рейтинг: Цена: 21940.00 р. Наличие на складе: Поставка под заказ.
Описание: Documenting the latest research in the field of different pathogenic organisms, this book presents the current scenario about promising antimicrobials in the following areas: Part I. Plants as source of antibacterials, Part II. Naturally occurring antifungal natural products, Part III. Antiparasitic natural products, Part IV. Antiviral natural products. Renowned scientists from the globe have been selected as authors to contribute chapters. Use of plants for various ailments is as old as human civilization and continuous efforts are being made to improve medicinal plants or to product their bioactive secondary metabolites in high amounts through various technologies. About 200,000 natural products of plant origin are known and many more are being identified from higher plants and micro-organisms. Some plants based drugs are used since centuries and there is no alternative medicine for many such drugs as cardiac glycosides. Drug discovery from medicinal plants or marine micro-organisms continues to provide an important source of new drug leads. Research on new antibacterials represents a real and timely challenge of this century, particularly for the treatment of infections caused by clinical isolates that show multidrug resistance. The main microorganisms involved in the resistance process have been identified and given the acronym ESKAPE for Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa and Enterobacteriaceae. Multidrug resistant Mycobacterium tuberculosis including highly drug-resistant strains (XDR-TB) has also emerged as one of the most important clinical challenges of this century. Plants of diverse taxa and marine micro-organisms are rich source of these antimicrobials. An attempt has been made to compile the recent information about natural sources of antibacterials and their sustainable utilization. Increased panic of these pathogens warrants a growing demand for research to undertake the threat of multidrug resistance. The search for new antifungal, antiparasitic and antiviral natural products is far from devoid of interest. According to the WHO report in 2013, malaria still represents some 207 million cases worldwide and more than 3 billion of people are still exposed to this risk. Similarly, about 350 million people are considered at risk of contracting leishmaniasis. The fight against some viruses also requires that the research on natural products continue. For example, even if an antiretroviral with direct action was recently approved in Europe in 2013, its high cost does not allow to offer it to an exposed population in countries where the cost of drugs remains a problem for a large part of the population. These books are useful to researchers and students in microbiology, biotechnology, pharmacology, chemistry and biology as well as medical professionals.
Автор: Djamel Drider; Sylvie Rebuffat Название: Prokaryotic Antimicrobial Peptides ISBN: 1489994777 ISBN-13(EAN): 9781489994776 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book will provide an overview of the advancement of fundamental knowledge and applications of antimicrobial peptides in biomedical, agricultural, veterinary, food, and cosmetic products.
Автор: Chin-Yi Chen Название: Antimicrobial Resistance and Food Safety ISBN: 0128012145 ISBN-13(EAN): 9780128012147 Издательство: Elsevier Science Рейтинг: Цена: 15159.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Antimicrobial Resistance and Food Safety: Methods and Techniques introduces antimicrobial resistant food-borne pathogens, their surveillance and epidemiology, emerging resistance and resistant pathogens. This analysis is followed by a systematic presentation of currently applied methodology and technology, including advanced technologies for detection, intervention, and information technologies. This reference can be used as a practical guide for scientists, food engineers, and regulatory personnel as well as students in food safety, food microbiology, or food science.
Includes analysis of all major pathogens of concern
Provides many case studies and examples of fundamental research findings
Presents recent advances in methodologies and analytical software
Demonstrates risk assessment using information technologies in foodborne pathogens
Автор: Jeffrey K. Aronson Название: Meyler`s Side Effects of Antimicrobial Drugs, ISBN: 0444532722 ISBN-13(EAN): 9780444532725 Издательство: Elsevier Science Рейтинг: Цена: 8420.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Suitable for internal medicine physicians and general practitioners who prescribe antibiotic drugs, like penicillin and tetracycline that cure bacterial infections, and antiviral drugs used to treat patients with HIV and herpes viruses.
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