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Myeloid Leukemia: Methods and Protocols, Iland Harry, Hertzberg Mark, Marlton Paula


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Автор: Iland Harry, Hertzberg Mark, Marlton Paula
Название:  Myeloid Leukemia: Methods and Protocols
ISBN: 9781607614562
Издательство: Springer
Классификация:
ISBN-10: 1607614561
Обложка/Формат: Paperback
Страницы: 307
Вес: 0.45 кг.
Дата издания: 07.03.2011
Серия: Methods in molecular medicine
Язык: English
Издание: 1st ed. 2006
Иллюстрации: 69 illustrations, black and white; 320 p. 69 illus.
Размер: 23.11 x 19.56 x 1.52 cm
Читательская аудитория: Professional & vocational
Подзаголовок: Methods and protocols
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: A panel of internationally recognized research scientists and clinical investigators brings together a diverse collection of readily reproducible methods for identifying and quantifying a large number of specific genetic abnormalities associated with the broad spectrum of myeloid malignancies. Highlights include techniques for the detection of BCR-ABL mutations and resistance to imatinib mesylate, detection of the FIP1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia, classification of AML by DNA-oligonucleotide microarrays, and detection of the V617F JAK2 mutation in myeloproliferative disorders. In addition to gene rearrangments, other prognostically relevant molecular lesions such as FLT3 mutations and WT-1 overexpression are covered.
Дополнительное описание: Isolation of RNA and DNA From Leukocytes and cDNA Synthesis.- Cytogenetic and FISH Techniques in Myeloid Malignancies.- Overview of Real-Time RT-PCR Strategies for Quantification of Gene Rearrangements in the Myeloid Malignancies.- Diagnosis and Monitorin



Targeted Therapy of Acute Myeloid Leukemia

Автор: Michael Andreeff
Название: Targeted Therapy of Acute Myeloid Leukemia
ISBN: 1493913921 ISBN-13(EAN): 9781493913923
Издательство: Springer
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Цена: 25155.00 р.
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Описание: This book provides an unprecedented overview of "Targeted Therapies" for acute myeloid leukemias. It aims at an almost comprehensive coverage of the diverse therapeutic strategies that have been developed during the last decade and are now being evaluated in early clinical trials. Paired and authoritative chapters by leading research scientists and clinicians explain basic concepts and clinical translation of topics that include the underlying genetic and proteomic abnormalities of AML, the development of novel nucleoside analogues, the roles of microRNAs, apoptosis regulators Bcl-2 and p53 and of critical cell signaling proteins such as PIM, FLT3, Raf/MEK, PI3K/AKT/mTOR and aurora kinases. Chapters on epigenetic mechanisms, nuclear receptors, cell surface antigens, the hypoxic leukemia microenvironment, stem cells and leukemia metabolism provide insights into leukemia cell vulnerabilities. Cell therapies utilizing T-, NK- and mesenchymal stem cells and progress in hematopoietic transplantation strategies round up this overview of the multi-dimensional therapeutic landscape in which leukemia specialists develop treatment strategies that are expected to make "leukemia history" in the near future.

New Findings on Aclarubicin in the Treatment of Acute Myeloid Leukemia

Автор: W. Hiddemann; R. Mertelsmann
Название: New Findings on Aclarubicin in the Treatment of Acute Myeloid Leukemia
ISBN: 3540526137 ISBN-13(EAN): 9783540526131
Издательство: Springer
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Цена: 15372.00 р.
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Описание: Provides information about the current status of aclacinomycin A for the treatment of haematologic malignancies. The text includes accounts of the action of aclacinomycin A in myelodysplastic syndromes and of its efficacy in acute myeloid leukemias.

Acute Myeloid Leukemia

Автор: Paolo Fortina; Eric Londin; Jason Y. Park; Larry J
Название: Acute Myeloid Leukemia
ISBN: 1493971409 ISBN-13(EAN): 9781493971404
Издательство: Springer
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Цена: 19564.00 р.
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Описание: This volume describes up-to-date techniques used in understanding the molecular biology of acute myeloid leukemia (AML) and addressing advances in diagnosis, classification, prognostication, and therapeutic strategies to potentially impact overall patient survival.

Chronic Myeloid Neoplasias and Clonal Overlap Syndromes

Автор: Richard Greil; Lisa Pleyer; Daniel Neureiter; Vikt
Название: Chronic Myeloid Neoplasias and Clonal Overlap Syndromes
ISBN: 3709120039 ISBN-13(EAN): 9783709120033
Издательство: Springer
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Цена: 30745.00 р.
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Описание: Introduction The understanding of the genetic, epigenetic, immuno- well as for practicing hematologists or oncologists. logical and biological causes of myeloproliferative dis- Each chapter follows a similar architecture and leads orders has substantially improved in the last few years. through epidemiology, genetic and molecular causes, Together with refined tools in pathology, the successful hematological and clinical findings, prognostic factors establishment of mouse models mimicking at least some and current treatment approaches of the diseases. of the myeloproliferative disorders, and murine models Effort has been made to point out the evolving field of novel drugs in this arena but simultaneously diff- allowing to carefully dissect the role of mutations and gene dosage effects of, for example JAK2, this has led to entiate between standard and experimental treatment ever increasing numbers of modified classification approaches. schemes. It is therefore important for the heamtologist Together with the co-editors and all the authors of or oncologist to keep up with this rapid change in classi- the various chapters I hope that the readers of the book fication language, the upcoming of new entities or differ- will enjoy reading and benefit from the information entiation between, or subclassification of, rare diseases provided.

Precision Molecular Pathology of Myeloid Neoplasms

Автор: Chung-Che (Jeff) Chang; Robert S. Ohgami
Название: Precision Molecular Pathology of Myeloid Neoplasms
ISBN: 3319621440 ISBN-13(EAN): 9783319621449
Издательство: Springer
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Цена: 27950.00 р.
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Описание: Written by experts in the field, Precision Molecular Pathology of Myeloid Neoplasms serves as a valuable resource for pathologists, hematologists/oncologists, fellows, and researchers in understanding the molecular pathology of myeloid neoplasms.

Chronic Myeloid Leukaemia

Автор: Carella
Название: Chronic Myeloid Leukaemia
ISBN: 185317890X ISBN-13(EAN): 9781853178900
Издательство: Informa
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Цена: 15886.00 р.
Наличие на складе: Нет в наличии.

Описание: Drawing on the expertise of an international team of experts in chronic myeloid leukemia, this book provides insight into the latest advances and the implications those developments have for management of the disease. The editors and their panel of contributors explore many topics, including a review of molecular and cellular biology, a discussion of conventional chemotherapy and interferon therapy, and recent developments in allografting and autografting. The reader gains not only an incisive view of the biological structure of the disease, but applications of that biology to treatment modalities. The book emphasizes treatment strategies and is a guide to complex treatment options.

Mechanisms in Myeloid Tumorigenesis 1988

Автор: Grace L.C. Shen-Ong; Michael Potter; Neal G. Copel
Название: Mechanisms in Myeloid Tumorigenesis 1988
ISBN: 364274625X ISBN-13(EAN): 9783642746253
Издательство: Springer
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Цена: 18167.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Pediatric Acute Lymphoblastic Leukemia

Автор: Kato
Название: Pediatric Acute Lymphoblastic Leukemia
ISBN: 9811505470 ISBN-13(EAN): 9789811505478
Издательство: Springer
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Цена: 13974.00 р.
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Описание: This book discusses key aspects of childhood acute lymphoblastic leukemia (ALL), presenting the latest research on the biology and treatment of the disease and related issues.

Acute Leukemia: An Illustrated Guide to Diagnosis and Treatment

Автор: Emadi Ashkan, Karp Judith E.
Название: Acute Leukemia: An Illustrated Guide to Diagnosis and Treatment
ISBN: 1620701006 ISBN-13(EAN): 9781620701003
Издательство: Mare Nostrum (Eurospan)
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Цена: 18810.00 р.
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Описание: Provides a comprehensive and concise visual reference on acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) seen in children and adults. This book addresses all aspects of AML and ALL including their risk factors, cytogenetics and mutational characteristics, diagnoses, clinical management and prognoses. It presents complex information relying predominantly on pictorial depictions.

Modern Trends in Human Leukemia V

Автор: R. Neth; R. C. Gallo; M. F. Greaves; M. A. S. Moor
Название: Modern Trends in Human Leukemia V
ISBN: 3540118586 ISBN-13(EAN): 9783540118589
Издательство: Springer
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Цена: 18167.00 р.
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Описание: Organized on behalf of the Deutsche Gesellschaft fur Hamatologie und Onkologie, Wilsede, June 21-23, 1982


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