Cancer Stem Cell Resistance to Targeted Therapy, Maccalli Cristina, Todaro Matilde, Ferrone Soldano

Автор: Karp Daniel D
Название: Handbook of Targeted Cancer Therapy and Immunotherapy
ISBN: 1496389131 ISBN-13(EAN): 9781496389138
Издательство: Lippincott Williams & Wilkins
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Цена: 7979.00 р.
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Описание: A must-have resource for oncologists, researchers, and other cancer care professionals! This comprehensive yet concise reference includes clinical trial results of more than 190 targeted therapy and immunotherapy agents. Immunotherapy trial results expanded Tumor immunology section added Recent landmark trial results incorporated FDA approvals highlighted Approach clinical challenges from any direction. Chapters organized by tumor type, pathway, and drug name. Find information quickly and easily, using a color-coded, intuitive format. Small enough to fit in your lab coat pocket. Or, download the eBook to your smartphone or other device for even more convenient referencing. Enhance Your eBook Reading Experience: Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Автор: Phuc Van Pham
Название: Breast Cancer Stem Cells & Therapy Resistance
ISBN: 3319220195 ISBN-13(EAN): 9783319220192
Издательство: Springer
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Цена: 9141.00 р.
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Описание: This volume thoroughly examines breast cancer stem cells (BCSCs), from basic definitions to techniques for identifying, isolating, culturing, and targeting BCSCs for therapy;

Автор: Prosperi Jenifer R.
Название: Resistance to Targeted Therapies in Breast Cancer
ISBN: 3319888919 ISBN-13(EAN): 9783319888910
Издательство: Springer
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Цена: 15372.00 р.
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Описание: We present an in-depth description of resistance to targeted therapies in breast cancer. Targeted therapies discussed here include those used to treat ER+ or Her2+ breast cancers (i.e., Tamoxifen or trastuzumab) or those targeting signaling pathways aberrantly activated in triple negative breast cancer (i.e., EGFR and Wnt signaling).

Название: Resistance to photodynamic therapy in cancer
ISBN: 3319127292 ISBN-13(EAN): 9783319127293
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Understanding the underlying mechanisms in this process leads to the improvement of therapeutic modality, in combination with chemotherapy, immunotherapy, and radiotherapy. Photodynamic therapy is a minimally invasive therapeutic procedure that can exert a selective or preferential cytotoxic activity toward malignant cells. The procedure involves administration of an intrinsically non-toxic photosensitizing agent (PS) followed by irradiation at a wavelength corresponding to a visible absorption band of the sensitizer. In the presence of oxygen, a series of events lead to direct tumor cell death, damage to the microvasculature, and induction of a local inflammatory reaction. Studies reveal that PDT can be curative, particularly in early stage tumors and this volume explores the potential of PDT, but also reveals strategic approaches to overcome resistance in tumor cells.

Автор: Cristina Maccalli; Matilde Todaro; Soldano Ferrone
Название: Cancer Stem Cell Resistance to Targeted Therapy
ISBN: 3030166236 ISBN-13(EAN): 9783030166236
Издательство: Springer
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Цена: 13974.00 р.
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Описание: This book represents an up-dated summary of the state of the art of the characterization of cancer stem cell/ cancer initiating cell (CSC/CIC) properties. An overview of the definition and biological properties of CSCs/CICs as well as the role of these cells in determining the resistance to standard and immune-based therapies is provided. It also discusses limitations in the achievement of a definitive biological characterization of CSCs/CICs due to their high extent of plasticity and heterogeneity that is also mutually driven by the interaction of these cells with the tumor microenvironment. The limitations in targeting CSCs/CICs with immunotherapy are also explained together with explorative combination approaches that could increase the susceptibility of these cells to the recognition by immune cells. This book is conceived for a broad audience, including students, teachers, scientific experts. The critical revision of available results in terms of immunological profile of CSCs/CICs and the efficacy in targeting these cells by immunological approaches, results in a comprehensive and up to date recapitulation of the field and provides interesting suggestions on how to focus future investigations in order to assess the role of CSCs/CICs as prognostic and predictive biomarkers of responsiveness to therapies for cancer patients.

Автор: Thomas Efferth
Название: Resistance to Targeted ABC Transporters in Cancer
ISBN: 3319098004 ISBN-13(EAN): 9783319098005
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This critical review volume explores the theme of ABC transporters in the context of basic cancer research and its role in drug-resistant tumors. The chapters provided complement basic research by including investigations from translational applications to clinical oncology. The development of resistance is a major obstacle in cancer chemotherapy and the field has been moving rapidly in terms of determining the mechanisms for blocking ABC transporter-mediated drug efflux by specific inhibitors and thereby overcoming multidrug resistance. The volume covers these issues in careful detail. Additional topics include the relevance of ABC transporters in resistance to novel and established anticancer drugs and prognosis of patients to compounds, compounds used in photodynamic therapy, tyrosine kinase inhibitors and others. Furthermore, the potential of radiopharmaceuticals for diagnosis of multidrug-resistant tumors and of nanotechnology to combat drug-resistant tumors is also discussed.

Автор: Jenifer Prosperi
Название: Resistance to Targeted Therapies in Breast Cancer
ISBN: 331970141X ISBN-13(EAN): 9783319701417
Издательство: Springer
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Цена: 22359.00 р.
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Описание: We present an in-depth description of resistance to targeted therapies in breast cancer. Targeted therapies discussed here include those used to treat ER+ or Her2+ breast cancers (i.e., Tamoxifen or trastuzumab) or those targeting signaling pathways aberrantly activated in triple negative breast cancer (i.e., EGFR and Wnt signaling).

Автор: Thomas Efferth
Название: Resistance to Targeted ABC Transporters in Cancer
ISBN: 3319379968 ISBN-13(EAN): 9783319379968
Издательство: Springer
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Цена: 20896.00 р.
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Описание: This critical review volume explores the theme of ABC transporters in the context of basic cancer research and its role in drug-resistant tumors.

Автор: Rama Shanker Verma; Benjamin Bonavida
Название: Resistance to Immunotoxins in Cancer Therapy
ISBN: 3319172743 ISBN-13(EAN): 9783319172743
Издательство: Springer
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Цена: 19564.00 р.
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Описание: This book will be a guide to understanding resistance against targeted therapeutic approaches for cancer using immunotoxins. It contains a detailed review of the history and development of targeted therapy. As well, it includes an in-depth description of the molecular and cellular mechanisms involved in cancer resistance and several novel methods to overcome resistance. Each chapter discusses different aspects of resistance and covers all the factors that may contribute to resistance in cancer cells. Finally, this volume highlights the recent findings and advances associated with tackling cancer resistance.

Автор: Valentina Rapozzi; Giulio Jori
Название: Resistance to Photodynamic Therapy in Cancer
ISBN: 331938175X ISBN-13(EAN): 9783319381756
Издательство: Springer
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Цена: 18284.00 р.
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Описание: This volume provides a comprehensive review of resistance induced by photodynamic therapy (PDT) in tumor cells. Studies reveal that PDT can be curative, particularly in early stage tumors and this volume explores the potential of PDT, but also reveals strategic approaches to overcome resistance in tumor cells.

Автор: Robert F. Ozols
Название: Drug Resistance in Cancer Therapy
ISBN: 0792302443 ISBN-13(EAN): 9780792302445
Издательство: Springer
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Цена: 32004.00 р.
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Описание: Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfor- tunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion: first, by dividing the oncology literature into specific subdivisions such as lung can- cer, genitourinary cancer, and pediatric oncology; second, by asking emi- nent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

Автор: Mario Mandal?; Emanuela Romano
Название: Mechanisms of Drug Resistance in Cancer Therapy
ISBN: 3030105067 ISBN-13(EAN): 9783030105068
Издательство: Springer
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Цена: 20962.00 р.
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Описание: A major objective of this book is to reveal unprecedented opportunities to understand and overcome drug resistance through the clinical assessment of rational therapeutic drug combinations and the use of predictive and prognostic biomarkers to enable patient stratification and tailor treatments. It offers to the readers an updated overview on the possible reasons of failure of new and promising therapeutic opportunities.