Notch Signaling in Embryology and Cancer: Notch Signaling in Embryology, Reichrath Jцrg, Reichrath Sandra
Автор: Gary C. Schoenwolf et al. Название: Larsen`s Human Embryology, 6e ISBN: 032369604X ISBN-13(EAN): 9780323696043 Издательство: Elsevier Science Рейтинг: Цена: 11115.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Offering a well-organized, straightforward approach to a highly complex subject, Larsen's Human Embryology, 6th Edition, provides easy-to-read, comprehensive coverage of human embryonic development for today's students. It integrates anatomy and histology with cellular and molecular mechanisms, focusing on both normal development and congenital anomalies. Highly illustrated with superb drawings and photographs, it features a strong clinical focus based on the most up-to-date scientific discoveries and understanding.Contains new information on gene editing via CRISPr technology, organoids and the study of human disease, transcription factors and signaling pathways, and single cell sequencing.
Includes clinical scenarios that describe prevention, diagnosis, and treatment of human birth defects and disease. Features a superior art program, online animations, and high-quality drawings and photographs throughout-ideal for today's visual learners. * Includes a strong clinical emphasis through the use of Clinical Tasters, Embryology in Practice, and In the Clinic sections.
Provides additional information on mechanisms of development and research approaches and strategies to establish these mechanisms with In the Research Lab sections. Begins each chapter with an overview of main points as well as a graphical summary, with key terms listed in bold type. Covers the embryology information that today's medical students need to know for Board exams, clinics, and more, in a readable, straightforward manner.
Enhanced eBook version included with purchase. Your enhanced eBook allows you to access 50 narrated animations, multiple-choice questions, and all of the text, figures, and references from the book on a variety of devices.
Автор: Keith L. Moor Название: The Developing Human 11 IE ISBN: 0323611559 ISBN-13(EAN): 9780323611558 Издательство: Elsevier Science Рейтинг: Цена: 6336.00 р. Наличие на складе: Поставка под заказ.
Описание: Extensively revised to incorporate recent research and current clinical practice, The Developing Human: Clinically Oriented Embryology, 11th Edition, covers all aspects of normal and abnormal embryonic and fetal development. In a clear, concise manner and lavishly illustrated throughout, this textbook is designed to successfully meet the needs of medical and health sciences profession students, as well as those in graduate programs. It provides an easy-to-digest, comprehensive review of what can be a complex and challenging subject.
BONUS online features such as multiple-choice questions and narrated animations further support student success.
Автор: Sadler, Dr. T.W., PhD Название: Langman`s Medical Embryology, 14e. ISBN: 1975114841 ISBN-13(EAN): 9781975114848 Издательство: Lippincott Williams & Wilkins Рейтинг: Цена: 9146.00 р. Наличие на складе: Поставка под заказ.
Описание: Vibrantly illustrated with full-color diagrams and clinical images, Langman's Medical Embryology , 14th Edition helps medical, nursing, and health professions students confidently develop a basic understanding of embryology and its clinical relevance. Concise chapter summaries, captivating clinical correlates boxes, clinical problems, and a clear, concise writing style make the subject matter accessible and engaging to students throughout their courses. Updated content reflects the latest clinical findings on the effects of the Zika virus, urogenital system disorders, and more.
Clinical Correlates boxes tie clinically relevant content to case-based scenarios students may encounter in practice. More than 400 full-color illustrations, micrographs, and clinical images clarify key aspects of embryonic development. Problems to Solve with accompanying answers help assess student understanding.
Chapter summaries and an expanded glossary reinforce understanding of key development stages, terms, and clinical conditions. Illustrated Development Chart visually guides students through the stages of embryonic development at a glance. eBook available for purchase.
Fast, smart, and convenient, today's eBooks can transform learning. These interactive, fully searchable tools offer 24/7 access on multiple devices, the ability to highlight and share notes, and more
Автор: Sadler Thomas Название: Langman`s Medical Embryology, International Edition 13e ISBN: 1469897806 ISBN-13(EAN): 9781469897806 Издательство: Lippincott Williams & Wilkins Рейтинг: Цена: 5577.00 р. Наличие на складе: Поставка под заказ.
Описание: Offering exceptional full color diagrams and clinical images, Langman's Medical Embryology, 13e helps medical, nursing, and health professions students develop a basic understanding of embryology and its clinical relevance. Concise chapter summaries, captivating clinical correlates boxes, clinical problems, and a clear, concise writing style make the subject matter accessible to students and relevant to instructors. The new edition is enhanced by over 100 new and updated illustrations, additional clinical images and photos of early embryologic development, and an expanded chapter on the cardiovascular system. In addition, online teaching and learning resources include the fully searchable text online, as well as an interactive Quiz Bank for students and an image bank.Clinical Correlates boxes illustrated by cases and images cover birth defects, developmental abnormalities, and other clinical phenomena.More than 400 illustrations—including full-color line drawings, scanning electron micrographs, and clinical images—clarify key aspects of embryonic development.Basic genetic molecular biology principles are highlighted throughout the text to link embryology to other critical specialties.Chapter Overview figures provide a visually compelling introduction to each chapter.Problems to Solve (with detailed answers at the back of the book) help you assess your understanding.An expanded glossary defines key terms and concepts.An online interactive USMLE-style Question Bank helps you review for exams and prepare for the Boards.
Автор: Appasani Название: Stem Cells & Regenerative Medicine ISBN: 1607618591 ISBN-13(EAN): 9781607618591 Издательство: Springer Рейтинг: Цена: 21424.00 р. 30606.00-30% Наличие на складе: Есть (1 шт.) Описание: Defined as, “The science about the development of an embryo from the fertilization of the ovum to the fetus stage,” embryology has been a mainstay at universities throughout the world for many years. Throughout the last century, embryology became overshadowed by experimental-based genetics and cell biology, transforming the field into developmental biology, which replaced embryology in Biology departments in many universities. Major contributions in this young century in the fields of molecular biology, biochemistry and genomics were integrated with both embryology and developmental biology to provide an understanding of the molecular portrait of a “development cell.” That new integrated approach is known as stem-cell biology; it is an understanding of the embryology and development together at the molecular level using engineering, imaging and cell culture principles, and it is at the heart of this seminal book. Stem Cells and Regenerative Medicine: From Molecular Embryology to Tissue Engineering is completely devoted to the basic developmental, cellular and molecular biological aspects of stem cells as well as their clinical applications in tissue engineering and regenerative medicine. It focuses on the basic biology of embryonic and cancer cells plus their key involvement in self-renewal, muscle repair, epigenetic processes, and therapeutic applications. In addition, it covers other key relevant topics such as nuclear reprogramming induced pluripotency and stem cell culture techniques using novel biomaterials. A thorough introduction to stem-cell biology, this reference is aimed at graduate students, post-docs, and professors as well as executives and scientists in biotech and pharmaceutical companies.
Описание: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer.
Описание: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer.
1. Notch signaling in prevention ant therapy: fighting cancer with a two-sided sword
2. Transcription factor RBPJ as a molecular switch in regulating the Notch response
3. Unraveling of Hidden Secrets: The tumour suppressor Lethal (2) giant discs (Lgd)/CC2D1, Notch Signaling and Cancer
4. Notch and endometrial cancer
5. Notch and Esophageal Squamous Cell Carcinoma
6. Notch signaling and liver cancer
7. Notch inHead and Neck Cancer
8. Notch Signaling and Human Papillomavirus-Associated Oral Tumorigenesis
9. The impact of Notch signalingfor carcinogenesis and progression of non-melanoma skin cancer: lessons learned fromcancer stem cells, tumor angiogenesis, and beyond
10. Notch Signaling in Thyroid Cancer
11. The Relevance of Notch Signaling in Cancer Progression
12. Notch Signaling and the Breast Cancer Microenvironment
13. Notch pathway: a journey from notching phenotypes to cancer immunotherapy
Index
Автор: Koji Yasutomo Название: Notch Signaling ISBN: 9811352801 ISBN-13(EAN): 9789811352805 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Поставка под заказ.
Описание: Also, the studies regarding the functions of Notch in immune cells and tumor cells have motivated researchers and pharmaceutical companies to develop drugs for treating immune-mediated diseases and tumors.
Автор: House, Patrick Название: Notch Signaling Research ISBN: 1071622005 ISBN-13(EAN): 9781071622001 Издательство: Springer Рейтинг: Цена: 21661.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The collected research methods and protocols include the dissection of Notch functional sites, Notch regulators, Notch activity reporters and analysis, roles of Notch in development and diseases, wet and dry lab tools and studies, and bioinformatics analysis.
Автор: Lucio Miele; Spyros Artavanis-Tsakonas Название: Targeting Notch in Cancer ISBN: 1493988573 ISBN-13(EAN): 9781493988570 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The serendipitously discovered link between developmental biology and cancer, touched of an explosion of discoveries on the role of Notch in human malignancies, including every aspect of cancer biology, from control of differentiation, proliferation and apoptosis in transformed cells to angiogenesis, tumor-stroma interaction and anti-cancer immune responses. A number of observations have revealed that Notch even plays a role in the renewal of cancer stem cells and tumor initiating cells, which are thought to be a major cause of resistance to treatment. Targeting Notch in Cancer will provide researchers, oncologists, pharmacologists and students with a detailed understanding of the intricate cross-talk between Notch and other pathways of therapeutic interest so to better design rational drug combinations for specific diseases and disease subsets.Divided into two parts, Part I describes in detail what we know about the genetics, molecular biology, biochemistry and structural biology of Notch, as well as the role of Notch in such processes as angiogenesis and immune surveillance. Without insights gained from these basic studies, rational targeting of Notch in human disease would be impossible. Part II describes the role of Notch and ongoing experimental therapeutic efforts in the most important subtypes of human cancers, organized in a clinically oriented fashion by organs and systems affected
Автор: Henry J. Leese; Daniel R. Brison Название: Cell Signaling During Mammalian Early Embryo Development ISBN: 1493924796 ISBN-13(EAN): 9781493924790 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book considers signaling events from the zygote embryo through to the blastocyst with relevant data from embryonic stem (ES) cells, including dialogue with the extracellular environment and with the maternal tract during the implantation process. Application of the knowledge described to improve the success of human and animal assisted conception is considered where appropriate, but the focus is largely on fundamental rather than applied cell/molecular biology, as this is the area that has historically been neglected. While the general features of metabolism during preimplantation development are well established, especially in terms of nutrient requirements, uptake and fate, remarkably little is known about early embryo signaling events, intracellular or intercellular, between individual embryos in vitro or with the female reproductive tract in vivo. This contrasts with the wealth of information on cell signaling in somatic cells and tissues, as a glance at any textbook of biochemistry illustrates. This lack of information is such that our understanding of the molecular cell biology of early embryos -- a prerequisite to defining the mechanisms which regulate development at this critical stage of the life cycle -- is seriously incomplete. This volume is the first to address this issue by describing the current state of knowledge on cell signaling during mammalian early embryo development and highlighting priority areas for research.
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