1. Notch signaling in prevention ant therapy: fighting cancer with a two-sided sword
2. Transcription factor RBPJ as a molecular switch in regulating the Notch response
3. Unraveling of Hidden Secrets: The tumour suppressor Lethal (2) giant discs (Lgd)/CC2D1, Notch Signaling and Cancer
4. Notch and endometrial cancer
5. Notch and Esophageal Squamous Cell Carcinoma
6. Notch signaling and liver cancer
7. Notch inHead and Neck Cancer
8. Notch Signaling and Human Papillomavirus-Associated Oral Tumorigenesis
9. The impact of Notch signalingfor carcinogenesis and progression of non-melanoma skin cancer: lessons learned fromcancer stem cells, tumor angiogenesis, and beyond
10. Notch Signaling in Thyroid Cancer
11. The Relevance of Notch Signaling in Cancer Progression
12. Notch Signaling and the Breast Cancer Microenvironment
13. Notch pathway: a journey from notching phenotypes to cancer immunotherapy
Index
Автор: Lucio Miele; Spyros Artavanis-Tsakonas Название: Targeting Notch in Cancer ISBN: 1493988573 ISBN-13(EAN): 9781493988570 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The serendipitously discovered link between developmental biology and cancer, touched of an explosion of discoveries on the role of Notch in human malignancies, including every aspect of cancer biology, from control of differentiation, proliferation and apoptosis in transformed cells to angiogenesis, tumor-stroma interaction and anti-cancer immune responses. A number of observations have revealed that Notch even plays a role in the renewal of cancer stem cells and tumor initiating cells, which are thought to be a major cause of resistance to treatment. Targeting Notch in Cancer will provide researchers, oncologists, pharmacologists and students with a detailed understanding of the intricate cross-talk between Notch and other pathways of therapeutic interest so to better design rational drug combinations for specific diseases and disease subsets.Divided into two parts, Part I describes in detail what we know about the genetics, molecular biology, biochemistry and structural biology of Notch, as well as the role of Notch in such processes as angiogenesis and immune surveillance. Without insights gained from these basic studies, rational targeting of Notch in human disease would be impossible. Part II describes the role of Notch and ongoing experimental therapeutic efforts in the most important subtypes of human cancers, organized in a clinically oriented fashion by organs and systems affected
Описание: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer.
Описание: This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer.
Автор: Hugo J. Bellen; Shinya Yamamoto Название: Notch Signaling ISBN: 1493955101 ISBN-13(EAN): 9781493955107 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Notch Signaling: Methods and Protocols focuses on molecular, biochemical and bioinformatics aspects of Notch signaling.
Автор: Koji Yasutomo Название: Notch Signaling ISBN: 9811352801 ISBN-13(EAN): 9789811352805 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Поставка под заказ.
Описание: Also, the studies regarding the functions of Notch in immune cells and tumor cells have motivated researchers and pharmaceutical companies to develop drugs for treating immune-mediated diseases and tumors.
Автор: Pereira Lygia V Название: Stem Cells: Promise And Reality ISBN: 9813100192 ISBN-13(EAN): 9789813100190 Издательство: World Scientific Publishing Рейтинг: Цена: 2376.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Stem Cells: Promises and Reality will tell you everything you have always wanted to know about stem cells, but could not understand the field from elsewhere.
Stem cells are the great therapeutic promise of the century, and this evolving field of research and medicine brings with it many legal, ethical and psychological issues that must be discussed by society as a whole.
Written so as to be accessible to general readers as well as specialists, this book explains what stem cells are, and the different aspects of stem cell research and applications. The book will enable the reader to understand the field sufficiently to critically participate in the public debates regarding stem cell research and society and ethics. By the end of the book, the reader will also be able to judge news on the stem cells field, and to discern what are real advances and what are phony treatments.
The main advantage of this book in comparison with other "stem cells for the general public" books is that it assumes the reader knows NOTHING about biology, except what is already common knowledge (for example, that we are made of cells). The book constructs step by step the required basic biology knowledge in order for the reader to understand all the different aspects of stem cells. At the same time that it is thorough in its stem cells-based content, and will keep the reader engaged with its narrative.
Автор: Pereira Lygia V Название: Stem Cells: Promise And Reality ISBN: 9813100184 ISBN-13(EAN): 9789813100183 Издательство: World Scientific Publishing Рейтинг: Цена: 4594.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Stem Cells: Promises and Reality will tell you everything you have always wanted to know about stem cells, but could not understand the field from elsewhere.
Stem cells are the great therapeutic promise of the century, and this evolving field of research and medicine brings with it many legal, ethical and psychological issues that must be discussed by society as a whole.
Written so as to be accessible to general readers as well as specialists, this book explains what stem cells are, and the different aspects of stem cell research and applications. The book will enable the reader to understand the field sufficiently to critically participate in the public debates regarding stem cell research and society and ethics. By the end of the book, the reader will also be able to judge news on the stem cells field, and to discern what are real advances and what are phony treatments.
The main advantage of this book in comparison with other "stem cells for the general public" books is that it assumes the reader knows NOTHING about biology, except what is already common knowledge (for example, that we are made of cells). The book constructs step by step the required basic biology knowledge in order for the reader to understand all the different aspects of stem cells. At the same time that it is thorough in its stem cells-based content, and will keep the reader engaged with its narrative.
Автор: Alexander V. Ereskovsky Название: The Comparative Embryology of Sponges ISBN: 9400791542 ISBN-13(EAN): 9789400791541 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The Comparative Embryology of Sponges contains abundant original and literary data on comparative embryology and morphology of the Porifera (Sponges), a group of `lower Metazoa`.
Автор: Hans K. Uhthoff Название: The Embryology of the Human Locomotor System ISBN: 3642753124 ISBN-13(EAN): 9783642753121 Издательство: Springer Рейтинг: Цена: 14365.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The pro- gression of changes taking place during the next 3 weeks is so rapid that at the time when the embryo measures 3 cm, all structures familiar to us are not only easily recognizable, but also already in their anatomical position.
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