Ion Transport Across Epithelial Tissues and Disease: Ion Channels and Transporters of Epithelia in Health and Disease - Vol. 2, Hamilton Kirk L., Devor Daniel C.
Описание: This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. As the authors show, these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their contribution to maintaining homeostasis. Readers will be introduced to the fundamentals of ion transport in terms of function, modelling, regulation, structure and pharmacology. This is the first of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on basic fundamentals of epithelial transport physiology. There is a range of chapters dedicated to specific aspects of epithelial ion transport and cell function. Accordingly, the authors discuss techniques used to determine epithelial function, principles of epithelia transport, polarization of epithelial cells, mathematical modelling of epithelial ion transport, protein folding of ion channels, degradation epithelial ion channels, fundamentals of epithelial sodium, potassium and chloride transport, fundamentals of bicarbonate secretion, volume regulation, and microRNA regulation of epithelial channels and transporters. Given its scope, Volume 1 offers a valuable resource for physiology students, scientists and clinicians alike.
Автор: Kirk L. Hamilton; Daniel C Devor Название: Ion Channels and Transporters of Epithelia in Health and Disease ISBN: 1493933647 ISBN-13(EAN): 9781493933648 Издательство: Springer Рейтинг: Цена: 34937.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters.
Автор: George A. Gerencser Название: Epithelial Transport Physiology ISBN: 1627038434 ISBN-13(EAN): 9781627038430 Издательство: Springer Рейтинг: Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The theme of this book is epithelial transport of molecules and ions, which includes the regulation of these mechanisms either directly, through secondary messengers, or via nuclear commands. Contributors were selected for their outstanding accomplishments.
Автор: N.K. Wills; L. Reuss; S.A. Lewis Название: Epithelial Transport ISBN: 9401071683 ISBN-13(EAN): 9789401071680 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Building from general principles, the authors clearly explain the fundamental role of epithelia in plasma electrolyte and water balance. Emphasis is placed on experimental approaches and methodology. A comprehensive glossary of terms is included.
Автор: Tang, Xin Название: Neuronal Chloride Transporters In Health And Disease ISBN: 0128153180 ISBN-13(EAN): 9780128153185 Издательство: Elsevier Science Рейтинг: Цена: 26444.00 р. Наличие на складе: Поставка под заказ.
Описание:
In the past several years, there has been an exciting body of new research that links impairments in the expression or function of neuronal chloride transporters to a growing number of diseases spanning from autism to brain aging. This book introduces the core concepts and highlights the recent advances in understanding the physiology and pathophysiology of the KCC and NKCC families of neuronal chloride transporters. Neuronal chloride transporter biology is reviewed, including roles in setting the transmembrane chloride gradient and the chloride transport-independent functions, such as regulating excitatory neurotransmission. Chapters are also dedicated to addressing the structure, post-translational modification, membrane trafficking, and protein interaction partners of neuronal chloride transporters, as well as the genetic and environmental factors that regulate their expression in neurons and the novel therapeutic approaches that target neuronal chloride transporters to treat neurological diseases. This new volume will provide readers with an up-to-date summary of the recent advances in neuronal chloride transporter research, with particular emphasis on some of the key emerging topics in the field.
Описание: This textbook offers an overview of structures and functions of ion channels and transporters in the heart. Among the topics covered in the work are the molecular biology and electrophysiology of all the important ion channels, and the pharmacology and pathophysiology of relevant ion channels.
Автор: Karobi Moitra Название: ABC Transporters and Human Genetic Disease ISBN: 1615043780 ISBN-13(EAN): 9781615043781 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 6237.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The ATP-binding cassette (ABC) transporter genes are ubiquitous in the genomes of all vertebrates so far studied. The human ABC transporter superfamily contains 48 genes, subdivided into 7 subfamilies ranging from A to G (based on sequence homology of their nucleotide binding domains). The ABC proteins encoded by these genes are ATP-driven transmembrane pumps, some of which possess the capacity to efflux harmful toxic substances and therefore play a key role in xenobiotic defense. ABC proteins have been evolutionarily conserved from bacteria to humans and multiple gene duplication and deletion events in the ABC genes indicate that the process of gene evolution is still ongoing. Polymorphisms and variations in these genes are linked to variations in expression, function, drug disposition, and drug response. Single nucleotide polymorphisms (SNPs) in these genes could be markers of individual risk for adverse drug reactions or susceptibility to complex diseases. The pharmacogenetics of this unique family of transporters is still under study; however, in the context of human health, it is a well-known fact that variations in these transporters are the underlying cause for several human diseases including cystic fibrosis, Pseudoxanthoma elasticum (PXE), and X-linked adenoleukodystrophy (X-ALD).
Автор: N.K. Wills; L. Reuss; S.A. Lewis Название: Epithelial Transport ISBN: 0412434008 ISBN-13(EAN): 9780412434006 Издательство: Springer Рейтинг: Цена: 28734.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Building from general principles, the authors clearly explain the fundamental role of epithelia in plasma electrolyte and water balance. Emphasis is placed on experimental approaches and methodology. A comprehensive glossary of terms is included.
Описание: Non-vesicular intracellular cholesterol transport is an important mechanism for maintaining membrane cholesterol homeostasis. Recent reports of studies directed at soluble cholesterol transport proteins indicate that aberrant expression of the START proteins may contribute to disease states associated with disorders in cholesterol homeostasis.
An Introduction to the Steroidogenic Acute Regulatory Protein (StAR)-related Lipid Transfer Domain Protein Family.- The Steroidogenic Acute Regulatory Protein (StAR).- START domain protein structure and ligand specificity.- Congenital Lipoid Adrenal Hyperplasia.- Steroidogenic Acute Regulatory protein (StAR) and Atherogenesis.- STARD3: a lipid transfer protein in breast cancer and cholesterol trafficking.- The STARD4 subfamily: STARD4 and STARD5 in cholesterol metabolism.- START proteins in non-vesicular cholesterol transport.- Index.
Автор: Tsang, Stephen H. Название: Crispr Genome Surgery In Stem Cells And Disease Tissues ISBN: 0128178760 ISBN-13(EAN): 9780128178768 Издательство: Elsevier Science Рейтинг: Цена: 19875.00 р. Наличие на складе: Поставка под заказ.
Описание:
CRISPR Genome Surgery in Stem Cells and Disease Tissues focuses uniquely on the clinical applications of CRISPR/Cas9 based technology. Topics include the latest advances in gene editing and its translational applications to various diseases, including retinal degenerative disease, recessively inherited diseases, and dominantly inherited diseases, to name a few. The book's target audience includes researchers, students, clinicians and the general public. This space that is not currently served by any existing resource, so this publication fills a gap in current literature.
Автор: T. F. McDonald; A. B. Chandler Название: Connective Tissues in Arterial and Pulmonary Disease ISBN: 146125969X ISBN-13(EAN): 9781461259695 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of a Symposium Held in Honor of Holde Puchtler, M.D., on October 15, 1980 in August, Georgia
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