Estrogens and Memory: Basic Research and Clinical Implications, Frick Karyn M.
Автор: D.W. Pfaff Название: Estrogens and Brain Function ISBN: 1461380863 ISBN-13(EAN): 9781461380863 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Eric Kandel and his colleagues have provided us with the most exciting contemporary approach to the conceptualization and study of cellular mechanisms for behavior.
Описание: This 8-chapter book is written by experts from China, Mexico, Portugal, United Kingdom and the United States of America. The book is focused on estrogen receptor structure, functions and clinical significance. Though we are unable to address all aspects of the estrogen receptors, we have analysed and discussed estrogen receptors or their isoforms in some major estrogen receptor-related disorders including cancers, endocrine diseases, respiratory diseases and obesity. The information provided by this book should aid our understanding the role of estrogen receptors in human diseases. This book will be of great value not only for clinicians interested in estrogen receptor-related diseases but also for basic scientists working in the field of estrogen receptors.
Автор: Juan Pedro Martinez-Barbera; Cynthia Lilian Andoni Название: Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma ISBN: 3319847708 ISBN-13(EAN): 9783319847702 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This astute volume brings together the latest expert research on adamantinomatous craniopharyngiomas (ACPs). ACPs are histologically benign but clinically aggressive tumors exhibiting a high propensity for local invasion into the hypothalamus, optic and vascular structures. These tumors, as well as the current treatments, may result in pan-hypopituitarism, diabetes insipidus, morbid obesity followed by type II diabetes mellitus, blindness, as well as serious behavioral and psychosocial impairments. Exploring in detail advances in both the understanding of tumor biology as well as clinical advances in patient management are explored in detail, this book will also look towards potential new treatment approaches.
Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma is the first book compiling all current research on ACPs. Mouse and human studies have unequivocally demonstrated that mutations in CTNNB1 encoding -catenin underlie the etiology of the majority, if not all ACP tumors. Genetic studies in mice have shown that ACPs are tumors of the pituitary gland and not of the hypothalamus as previously thought, and are derived from Rathke’s pouch precursors. In addition, a role for tissue-specific adult pituitary stem cells has been revealed as causative of ACP. Together, these studies have provided novel insights into the molecular and cellular etiology as well as the pathogenesis of human ACP. Finally, this volume covers new treatment approaches that have been shown to be effective both in reducing ACP burden as well as reducing the morbidity associated with therapy.
Автор: Juan Pedro Martinez-Barbera; Cynthia Lilian Andoni Название: Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma ISBN: 3319518887 ISBN-13(EAN): 9783319518886 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Pathogenesis of human ACP.- Transcriptomic and Genomic Analyses of Human Craniopharyngioma.- Genetically Modified Mouse Models of Adamantinomatous Craniopharyngioma.- Clinical Diagnosis of Human ACP.- Endocrine Deficits in Patients with Human Craniopharyngioma.- Obesity and metabolic disturbances in Adamantinomatous Craniopharyngioma Patients.- Radiology and Radiotherapy of Craniopharyngioma.- Surgical Treatment of Human ACP.- Intracystic Administration of Interferon-Alpha for Reduction of Cystic Tumour Burden.- Long-term Management and Clinical Trials in Adamantinomatous Craniopharyngioma
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