Modified Nucleic Acids in Biology and Medicine, Jurga Stefan, Erdmann (Deceased) Volker A., Barciszewski Jan

Автор: Snape Alison
Название: Biochemistry and Molecular Biology, 5 edition
ISBN: 0199609497 ISBN-13(EAN): 9780199609499
Издательство: Oxford Academ
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Цена: 6651.00 р.
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Описание: The ideal text for any bioscience student encountering biochemistry and molecular cell biology for the first time. Exceptionally clear explanations, frequent diagrams, and a user-friendly design and layout ensure that the text provides a perfect introduction to this complex yet fascinating subject area.

Автор: Robert L. Nussbaum, Roderick R. McInnes
Название: Thompson & Thompson Genetics in Medicine
ISBN: 1437706967 ISBN-13(EAN): 9781437706963
Издательство: Elsevier Science
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Цена: 5467.00 р. 7810.00 -30%
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Updated to reflect the newest changes in genetics, Thompson & Thompson's Genetics in Medicine returns as one of the most favored texts in this fascinating and rapidly evolving field. By integrating the classic principles of human genetics with modern molecular genetics, this medical reference book utilizes a variety of learning tools to help you understand a wide range of genetic disorders.

• Acquire the state-of-the-art knowledge you need on the latest advances in molecular diagnostics, the Human Genome Project, pharmacogenetics, and bio-informatics.
• Better understand the relationship between basic genetics and clinical medicine with a variety of clinical case studies.
• Recognize a wide range of genetic disorders with visual guidance from more than 240 dynamic illustrations and high-quality photos.

• Immerse yourself in updated graphics, full-color text, illustrations, line diagrams, and clinical photos of genetic diseases.
• Explore the latest genetic content available in order to remain up to date on the most current trends in the field.
• Take advantage of a double-page clinical case study section that demonstrates and reinforces general principles of disease inheritance, pathogenesis, diagnosis, management, and counseling.
• Enhance your critical thinking skills and better retain information. Each chapter ends with up to 5 quick genetic problems related to what has just been reviewed, with answers provided in the back of the book.
• Student Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices. You'll also access USMLE-style and multiple choice questions.

Автор: Lieberman, Michael A.
Название: BRS biochemistry, molecular biology, and genetics. 7 ed
ISBN: 1496399234 ISBN-13(EAN): 9781496399236
Издательство: Lippincott Williams & Wilkins
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Цена: 7901.00 р.
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Описание: Practical, approachable, and perfect for today's busy medical students and practitioners, BRS Biochemistry, Molecular Biology, and Genetics, Seventh Edition helps ensure excellence in class exams and on the USMLE Step 1. The popular Board Review Series outline format keeps content succinct and accessible for the most efficient review, accompanied by bolded key terms, detailed figures, quick-reference tables, and other aids that highlight important concepts and reinforce understanding.

This revised edition is updated to reflect the latest perspectives in biochemistry, molecular biology, and genetics, with a clinical emphasis essential to success in practice. New Clinical Correlation boxes detail the real-world application of chapter concepts, and updated USMLE-style questions with answers test retention and enhance preparation for board exams and beyond.

• Updated content keeps students current with the latest clinical approaches to molecular biology, genetics, amino acids, and more.
• The proven Board Review Series outline format helps students make the most of their study time.
• Updated Clinical Considerations boxes demonstrate the practical applications of chapter concepts.
• More than 500 USMLE-style review questions ensure confidence on course exams and the USMLE Step 1.
• More than 250 high-quality images clarify concepts and clinical details.
• Chapter overviews, tables, algorithms, and other learning aids save time and simplify the review process.
• eBook available for purchase. Fast, smart, and convenient, today's eBooks can transform learning. These interactive, fully searchable tools offer 24/7 access on multiple devices, the ability to highlight and share notes, and more

Название: Modified nucleic acids
ISBN: 3319271091 ISBN-13(EAN): 9783319271095
Издательство: Springer
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Цена: 19591.00 р.
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Описание: Emissive 5-Substituted Uridine Analogues.- Fluorescent purine nucleosides and their applications.- Thiazole orange-tethered nucleic acids and ECHO probes for fluorometric detection of nucleic acids.- Synthetic wavelength-shifting fluorescent probes of nucleic acids.- DNA Assisted Multichromophore Assembly.- Polymerase Synthesis of Base-Modified DNA.- Photo-cross-linking Reaction in Nucleic Acids - Chemistry and Applications.- Site-Directed Spin Labeling for EPR Studies of Nucleic Acids.- Non-Covalent Modification of Double Stranded DNA at the Mismatch and Bulged Site.- 2',4'-Bridged Nucleic Acids for Targeting Double-Stranded DNA.- Specific Recognition of Single Nucleotide by Alkylating Oligonucleotides and Sensing of 8-oxoguanine.- Genetic alphabet expansion by unnatural base pair creation and its application to high affinity DNA aptamers.

Автор: Nakatani Kazuhiko, Tor Yitzhak
Название: Modified Nucleic Acids
ISBN: 3319800760 ISBN-13(EAN): 9783319800769
Издательство: Springer
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Цена: 13974.00 р.
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Описание: Emissive 5-Substituted Uridine Analogues.- Fluorescent purine nucleosides and their applications.- Thiazole orange-tethered nucleic acids and ECHO probes for fluorometric detection of nucleic acids.- Synthetic wavelength-shifting fluorescent probes of nucleic acids.- DNA Assisted Multichromophore Assembly.- Polymerase Synthesis of Base-Modified DNA.- Photo-cross-linking Reaction in Nucleic Acids - Chemistry and Applications.- Site-Directed Spin Labeling for EPR Studies of Nucleic Acids.- Non-Covalent Modification of Double Stranded DNA at the Mismatch and Bulged Site.- 2',4'-Bridged Nucleic Acids for Targeting Double-Stranded DNA.- Specific Recognition of Single Nucleotide by Alkylating Oligonucleotides and Sensing of 8-oxoguanine.- Genetic alphabet expansion by unnatural base pair creation and its application to high affinity DNA aptamers.

Автор: Fritz Eckstein; David M. J. Lilley
Название: Nucleic Acids and Molecular Biology
ISBN: 3642837115 ISBN-13(EAN): 9783642837111
Издательство: Springer
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Цена: 18284.00 р.
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Описание: A wide range of topics are covered, including articles on nucleic acid structure, through their interactions with proteins to the control of gene expression. Gene transcription is also covered, from the points of view of DNA methylation, mammalian ribosomal and avian lysozyme genes, and the control of transcription in the proto-oncogene c-fos.

Автор: Volker A. Erdmann; Wojciech T. Markiewicz; Jan Bar
Название: Chemical Biology of Nucleic Acids
ISBN: 3642544517 ISBN-13(EAN): 9783642544514
Издательство: Springer
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Цена: 30745.00 р.
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Описание: This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap regions; new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids. This volume discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research.

Автор: Volker A. Erdmann; Wojciech T. Markiewicz; Jan Bar
Название: Chemical Biology of Nucleic Acids
ISBN: 3662513242 ISBN-13(EAN): 9783662513248
Издательство: Springer
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Цена: 23508.00 р.
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Описание: new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids.

Автор: Fritz Eckstein; David M. J. Lilley
Название: Nucleic Acids and Molecular Biology
ISBN: 3642773583 ISBN-13(EAN): 9783642773587
Издательство: Springer
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Цена: 18167.00 р.
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Описание: Molecular biology is one of the most rapidly growingdeveloping and at the same time most exciting disciplines. Nucleic Acids in Molecular Biology keepsscientists informed of the explosively growing informationand complies with the great interest in this field byoffering a continued high standard of review.

Автор: Volker A. Erdmann; Jan Barciszewski
Название: From Nucleic Acids Sequences to Molecular Medicine
ISBN: 364243083X ISBN-13(EAN): 9783642430831
Издательство: Springer
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Цена: 28732.00 р.
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Описание: Written by leading experts in the field , this book covers hot topics such as small interference RNAs for gene silencing in molecular biology and medicine. Includes numerous illustrations.

Автор: Goodman, Steven
Название: Medical Cell Biology. 3Ed.
ISBN: 0123704588 ISBN-13(EAN): 9780123704580
Издательство: Elsevier Science
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Цена: 4883.00 р.
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Описание: Focuses on the scientific aspects of cell biology useful to medical students, dental students, veterinary students, and prehealth undergraduates. This book explains general cell biology principles in the context of organ systems and human and animal disease.

Автор: Jurga
Название: Modified Nucleic Acids in Biology and Medicine
ISBN: 3319341731 ISBN-13(EAN): 9783319341736
Издательство: Springer
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Цена: 23757.00 р.
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Описание: This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties. The chemical nature of DNA, RNA, protein and lipids makes these macromolecules easily modifiable, but they are also susceptible to damage from both endogenous and exogenous agents. Alkylation and oxidation show a potential to disrupt the cellular redox equilibrium and cause cellular damage leading to inflammation and even chronic disease. Furthermore, DNA damage can drive mutagenesis and the resulting DNA sequence changes can induce carcinogenesis and cancer progression. Modified nucleosides can occur as a result of oxidative DNA damage and RNA turnover, and are used as markers for various diseases. To function properly some RNA needs to be chemically modified post-transcriptionally. Dysregulation of the RNA-modification pattern or of the levels of the enzymes that catalyze these modifications alters RNA functionality and can result in complex phenotypes, likely due to defects in protein translation. While modifications are best characterized in noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have also been found to contain modified nucleosides. This book is a valuable resource, not only for graduate students but also researchers in the fields of molecular medicine and molecular biology.