B Cell Receptor Signaling, Kurosaki Tomohiro, Wienands Jurgen
Автор: Chaohong Liu Название: T-Cell Receptor Signaling ISBN: 1071602659 ISBN-13(EAN): 9781071602652 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Поставка под заказ.
Описание: This volume provides current and new advanced methods and protocols to study T cells. Chapters guide readers through T cell diversity using mass cytometry, analyzing T cells from single cell level, CRISPR/Cas9 techniques to study the T cell activation, techniques to study subsets of Tcell’s, procedures to study artificial antigen presentosomes for T cell activation, techniques to study the T cell development, two-photon microscopy, and MAIT cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, T-Cell Receptor Signaling: Methods and Protocols aims to provide a wide range of approaches and be an invaluable resource for present and future generations of T cell researchers.
Автор: Alexander Sigalov Название: Multichain Immune Recognition Receptor Signaling ISBN: 1441918876 ISBN-13(EAN): 9781441918871 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book shows how the structural similarity of MIRRs determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms. In so doing, it provides the basis for existing and future therapeutic strategies targeting MIRRs.
Автор: Peter van den Elsen Название: The Human T-Cell Receptor Repertoire and Transplantation ISBN: 3662224968 ISBN-13(EAN): 9783662224960 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: these analyses it became clear that the MHC class I molecule com- prised a distinct groove on the external side of the molecule. * *- High resolu- tion crystallographic analyses of the class I MHC structure have revealed the existence of so-called pockets within the grooves of the MHC class I molecules.
Автор: Kamilla Swiech; Kelen Cristina Ribeiro Malmegrim; Название: Chimeric Antigen Receptor T Cells ISBN: 1071601458 ISBN-13(EAN): 9781071601457 Издательство: Springer Рейтинг: Цена: 11878.00 р. Наличие на складе: Поставка под заказ.
Описание: This volume provides comprehensive methods from expert scientists working in the Chimeric Antigen Receptor T Cell (CAR-T Cell) field. Chapters guide readers through the state-of-art of CAR-T cell technology, CAR design and vector production, CAR-T cell generation and manufacturing, CAR-T cell characterization, and quality control. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chimeric Antigen Receptor T Cells: Development and Production aims to be useful in the production of CAR-T cells, especially for therapeutic purposes.
Автор: Xiaoting Zhang Название: Estrogen Receptor and Breast Cancer ISBN: 3319993496 ISBN-13(EAN): 9783319993492 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics.
Автор: Tomohiro Kurosaki; J?rgen Wienands Название: B Cell Receptor Signaling ISBN: 3319261312 ISBN-13(EAN): 9783319261317 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Altogether, the discoveriespresented provide a better understanding of B cell biology and help to explainsome B cell-mediated pathogenicities, like autoimmune phenomena or theformation of B cell tumors, while also paving the way for eventually combating thesediseases.
Автор: Gerard Pasterkamp Название: Semaphorins: Receptor and Intracellular Signaling Mechanisms ISBN: 1441924272 ISBN-13(EAN): 9781441924278 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book details our progress in understanding the receptor and intracellular signaling mechanisms utilized by semaphorins. The comprehensive overview of semaphorin biology and signaling presented in this book allows one to compare semaphorin functions between different biological systems.
Автор: Marie-Paule Lefranc Название: The T Cell Receptor FactsBook, ISBN: 0124413528 ISBN-13(EAN): 9780124413528 Издательство: Elsevier Science Рейтинг: Цена: 13551.00 р. Наличие на складе: Поставка под заказ.
Описание: This is a reference for all functional and ORF T-cell receptor genes. Introductory chapters provide up-to-date information on T-cell receptor structural and biological properties, chain synthesis, gene chromosomal localization, and organization of the TRA, TRB, TRG and TRD loci. This is followed by entries on all 168 functional and ORF variable, diversity, joining and constant genes, and a complete overview of the potential repertoire of the human T-cell receptor alpha, beta, gamma and delta loc
Автор: Gerald Litwack Название: Receptor Purification ISBN: 146126779X ISBN-13(EAN): 9781461267799 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Vincent Laudet Название: The Nuclear Receptor FactsBook, ISBN: 0124377351 ISBN-13(EAN): 9780124377356 Издательство: Elsevier Science Рейтинг: Цена: 12464.00 р. Наличие на складе: Поставка под заказ.
Описание: Devoted to nuclear receptors, this work presents an introduction and describes the mode of action of the receptors in general. It also contains detailed entries covering each type of receptor. Entries provide information on: Nomenclature and structure; Isolation; DNA binding properties; Ligands; Expression; Target genes; Knockouts; and more.
Автор: Alan A. Boulton; Glen B. Baker; Pavel D. Hrdina Название: Receptor Binding ISBN: 0896030784 ISBN-13(EAN): 9780896030787 Издательство: Springer Рейтинг: Цена: 25853.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essential functions in cancer progression. Each chapter will cover a specific group of targets and the cognate drugs, along with molecular modes of innate and evolving resistance.
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