Histone Deacetylases: Methods and Protocols, Sarkar Sibaji

Автор: Jurga Stefan, Barciszewski Jan
Название: The Dna, Rna, and Histone Methylomes
ISBN: 3030147940 ISBN-13(EAN): 9783030147945
Издательство: Springer
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Цена: 23757.00 р.
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Описание: This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions. Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylate nucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms. This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells.

Автор: Stefan Jurga; Jan Barciszewski
Название: The DNA, RNA, and Histone Methylomes
ISBN: 3030147916 ISBN-13(EAN): 9783030147914
Издательство: Springer
Рейтинг:
Цена: 23757.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions. Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylate nucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms. This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells.

Автор: Guillemette Benoit, Gaudreau Luc R.
Название: Histones: Methods and Protocols
ISBN: 1493982540 ISBN-13(EAN): 9781493982547
Издательство: Springer
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Цена: 15372.00 р.
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Описание:

1. In Vitro Assembly of Nucleosomes For Binding/Remodeling Assays

Автор: Shelley L. Berger; O. Nakanishi; Bernhard Haendler
Название: The Histone Code and Beyond
ISBN: 364242175X ISBN-13(EAN): 9783642421754
Издательство: Springer
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Цена: 19564.00 р.
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Описание: Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin.

Автор: Benoit Guillemette; Luc R. Gaudreau
Название: Histones
ISBN: 1493966286 ISBN-13(EAN): 9781493966288
Издательство: Springer
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Цена: 19564.00 р.
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Описание: This volume provides a comprehensive list of protocols for molecular biologists, biochemists and geneticists. Chapters cover protocols that further the study into protein complexes that modify chromatin either by adding or removing post-translational modifications, or by exchanging histone variants within the nucleosome. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Histones: Methods and Protocols aims to ensure successful results in the further study of this vital field.