The Dna, Rna, and Histone Methylomes, Jurga Stefan, Barciszewski Jan
Автор: Stefan Jurga; Jan Barciszewski Название: The DNA, RNA, and Histone Methylomes ISBN: 3030147916 ISBN-13(EAN): 9783030147914 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions. Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylate nucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms. This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells.
Автор: Tso-Pang Yao; Edward Seto Название: Histone Deacetylases: the Biology and Clinical Implication ISBN: 3642270859 ISBN-13(EAN): 9783642270857 Издательство: Springer Рейтинг: Цена: 41925.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic disorders.
Автор: Shelley L. Berger; O. Nakanishi; Bernhard Haendler Название: The Histone Code and Beyond ISBN: 364242175X ISBN-13(EAN): 9783642421754 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin.
Автор: Orsi Название: Histone Variants ISBN: 1493986627 ISBN-13(EAN): 9781493986620 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume compiles methodologies used for detailed studies of histone variants, from their basic properties to their functional roles in chromatin and as vectors of epigenetic information. Its four sections cover experimental approaches to probe the biochemistry of histone variants and variant nucleosomes; their dynamics throughout the cell cycle and at specific genomic locations; their functional impact on chromosome organization and genome stability; and their importance in development, disease and evolution. Written in the highly successful Methods in Molecular Biology series format, chapters include lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, illustrations on the expected results, and tips on troubleshooting and avoiding known pitfalls. This anthology brings together contributions from many of the most highly recognized investigators in this community. Cutting-edge and thorough, Histone Variants: Methods and Protocols is a valuable resource for anyone interested in exploring the experimental and collaborative possibilities in this evolving field.
Автор: Sarkar Sibaji Название: Histone Deacetylases: Methods and Protocols ISBN: 1493981110 ISBN-13(EAN): 9781493981113 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Поставка под заказ.
Описание: This volume provides different methodologies for all classes of histone deacetylases, which includes detailed procedures on Class I and II histone deacetylase inhibitors, SIRT inhibitors, and bromodomain inhibitors.
Автор: Guillermo A. Orsi; Genevi?ve Almouzni Название: Histone Variants ISBN: 1493993585 ISBN-13(EAN): 9781493993581 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Поставка под заказ.
Описание: This volume compiles methodologies used for detailed studies of histone variants, from their basic properties to their functional roles in chromatin and as vectors of epigenetic information. Its four sections cover experimental approaches to probe the biochemistry of histone variants and variant nucleosomes; their dynamics throughout the cell cycle and at specific genomic locations; their functional impact on chromosome organization and genome stability; and their importance in development, disease and evolution. Written in the highly successful Methods in Molecular Biology series format, chapters include lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, illustrations on the expected results, and tips on troubleshooting and avoiding known pitfalls. This anthology brings together contributions from many of the most highly recognized investigators in this community. Cutting-edge and thorough, Histone Variants: Methods and Protocols is a valuable resource for anyone interested in exploring the experimental and collaborative possibilities in this evolving field.
Автор: Ming-Ming Zhou Название: Histone Recognition ISBN: 3319376667 ISBN-13(EAN): 9783319376660 Издательство: Springer Рейтинг: Цена: 16977.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides a timely review of the role of histone modifications in epigenetic control of gene expression.
Описание: This book provides an outline of epigenetics as a whole, while also specifically examining a range of epigenetic players, including histone acetyl transferases (HATs) and histone deacetylases (HDACs). It chiefly focuses on the emerging targets of HDACs and their implications for various neurological disorders, while also discussing the drawbacks of current therapeutic strategies, the classification of HDAC inhibitors, and their promising effects in connection with specific neurological disorders. The book explores the potential use of these inhibitors as novel therapeutic agents, considers the current challenges involved in using them to tackle neurological complications, and offers a novel solution by designing isoform-selective inhibitors and employing combinatorial therapeutic strategies. Its final section, which explores future directions, elaborates on the possibility of enhancing HDAC inhibitors’ therapeutic efficacy against various neurological complications.
Автор: Ming-Ming Zhou Название: Histone Recognition ISBN: 3319181017 ISBN-13(EAN): 9783319181011 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides a timely review of the role of histone modifications in epigenetic control of gene expression. Topics covered include: basic mechanisms of molecular recognition of histone post-translational modification (PTMs); combinatorial readout of histone PTMs by tandem epigenome reader domains; genome-wide profiling of histone PTM interactions; small molecule modulation of histone PTM interactions and their potential as a new approach to therapeutic intervention in human diseases. All chapters were written by leading scientists who made the original key discoveries of the structure and mechanism of evolutionarily conserved reader domains, which serve to direct gene transcription in chromatin through interactions with DNA-packing histones in a PTM-sensitive manner.
Автор: D. M. Philips Название: Histones and Nucleohistones ISBN: 1468418173 ISBN-13(EAN): 9781468418170 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Chapters 1, 2, part of 3, and all of Chapters 5 and 6, cover the occurrence, preparation, characterization, sequence structure, bio- physical properties and finally, the biosynthesis and functions of the histones.
Автор: Guillemette Benoit, Gaudreau Luc R. Название: Histones: Methods and Protocols ISBN: 1493982540 ISBN-13(EAN): 9781493982547 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
1. In Vitro Assembly of Nucleosomes For Binding/Remodeling Assays
Arnob Dutta and Jerry L. Workman
2. An Assay for Measuring Histone Variant Exchange within Nucleosomes In Vitro
Liette Laflamme, Benoit Guillemette, and Luc Gaudreau
3. Purification of Yeast Native Reagents for the Analysis of Chromatin Function-I: Nucleosomes for Reconstitution and Manipulation of Histone Marks
Nicolas Lacoste, Wajid Bhat, and Jacques Cфtй
4. Purification of Yeast Native Reagents for the Analysis of Chromatin Function-II: Multiprotein Complexes and Biochemical Assays
Nicolas Lacoste, Wajid Bhat, and Jacques Cфtй
5. Histone Purification from Saccharomyces Cerevisiae
Frederic Jourquin and Vincent Gйli
6. Analytical Ultracentrifuge Analysis of Nucleosomes Assembled from Recombinant, Acid Extracted, HPLC-Purified Histones
Manjinder S. Cheema and Juan Ausiу
7. Silac-Based Quantitative Strategies for Accurate Histone Post-Translational Modifications Profiling Across Multiple Biological Samples
Alessandro Cuomo, Monica Soldi, and Tiziana Bonaldi
8. Characterization of Individual Histone Post-Translational Modifications and their Combinatorial Patterns by Mass Spectrometry-Based Proteomics Strategies
Simone Sidoli and Benjamin A. Garcia
9. Production and Purification of Antibodies against Histone Modifications
Benoit Guillemette, Ian Hammond-Martel, Hugo Wurtele, and Alain Verreault
10. Immunofluorescence of Histone Proteins
Hilmar Strickfaden and Michael J. Hendzel
11. Acid-Urea Gel Electrophoresis and Western Blotting Of Histones
Catherine A. Hazzalin and Louis C. Mahadevan
12. Chromatin Immunoprecipitation of Histone Modifications in Fission Yeast
Jean Mbogning and Jason C. Tanny
13. A Spiking Strategy for Chip-Chip Data Normalization in S. Cerevisiae
Cйlia Jeronimo and Franзois Robert
14. High-Resolution Genome-Wide Mapping Of Nucleosome Positioning And Occupancy Level Using Paired-End Sequencing Technology
Mylиne Brunelle, Sйbastien Rodrigue, Pierre-Йtienne Jacques, and Nicolas Gйvry
15. Physarum Polycephalum for Studying the Function of Histone Modifications InVivo
Vanessa Menil-Philippot and Christophe Thiriet
16. A Method for Large Scale Screening of Random Sequence Libraries to Determine the Function of Unstructured Regions from Essential Proteins
Jean-Franзois Millau, Benoit Guillemette, and Luc Gaudreau
Автор: Benoit Guillemette; Luc R. Gaudreau Название: Histones ISBN: 1493966286 ISBN-13(EAN): 9781493966288 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume provides a comprehensive list of protocols for molecular biologists, biochemists and geneticists. Chapters cover protocols that further the study into protein complexes that modify chromatin either by adding or removing post-translational modifications, or by exchanging histone variants within the nucleosome. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Histones: Methods and Protocols aims to ensure successful results in the further study of this vital field.
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