Map Kinase Signaling Protocols, Seger Rony

Автор: Sergei V. Kozlov
Название: ATM Kinase
ISBN: 1493969536 ISBN-13(EAN): 9781493969531
Издательство: Springer
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1. Assaying Radiosensitivity of Ataxia-Telangiectasia

16. Mass Spectrometry-Based Proteomics for Quantifying DNA Damage-Induced Phosph

Автор: Nancy Y. Ip; Li-Huei Tsai
Название: Cyclin Dependent Kinase 5 (Cdk5)
ISBN: 1489987746 ISBN-13(EAN): 9781489987747
Издательство: Springer
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Описание: This book provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5. It further reviews the potential implication of Cdk5 in the treatment of neurodegenerative diseases.

Автор: Peter K. Vogt; Stephen I. Reed
Название: Cyclin Dependent Kinase (CDK) Inhibitors
ISBN: 3642719430 ISBN-13(EAN): 9783642719431
Издательство: Springer
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Описание: More than 10 years ago, the discovery of cyclin-dependent ki- nases (Cdks) ushered in a new era in the understanding of cell proliferation and its control.

Автор: Fu Zheng
Название: Characterization of Four Alternatively Spliced Casein Kinase 1 Alpha Isoforms
ISBN: 0530005867 ISBN-13(EAN): 9780530005867
Издательство: Неизвестно
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Описание: Abstract:

Identify specific casein kinase I isoforms as neurofilament-associated kinases and elucidate their subcellular localization mechanism

Dissertation Discovery Company and University of Florida are dedicated to making scholarly works more discoverable and accessible throughout the world. This dissertation, "Characterization of Four Alternatively Spliced Casein Kinase 1 Alpha Isoforms" by Zheng Fu, was obtained from University of Florida and is being sold with permission from the author. A digital copy of this work may also be found in the university's institutional repository, IR@UF. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation.

Автор: Khalil Ahmed; Olaf-Georg Issinger; Ryszard Szyszka
Название: Protein Kinase CK2 Cellular Function in Normal and Disease States
ISBN: 3319145436 ISBN-13(EAN): 9783319145433
Издательство: Springer
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Описание: Protein kinase CK2 (formerly casein kinase II or 2) is known to play a critical role in the control of cell growth and cell death and is thus intimately involved in the development of cancer. More specifically, CK2 has been found to be elevated in all cancers examined. While CK2 levels are known to be high in proliferating normal cells, CK2 has also been found to be a potent suppressor of apoptosis and is a link to the cancer cell phenotype, which is characterized by deregulation of both cell proliferation and cell death. Indeed, it would appear that CK2 impacts many of the hallmarks of cancer and it has now gained considerable attention as a potential target for cancer therapy. Protein Kinase CK2 and Cellular Function in Normal and Disease States increases knowledge of the role of CK2 in the development of cellular dysfunction and emphasizes that this protein may serve as a target of drug development for improved cancer therapy. In addition, it is a handy tool that provides cancer researchers, graduate students, and all scientists involved in CK2 research with one main source for the latest advances in CK2 research.

Автор: Fu Zheng
Название: Characterization of Four Alternatively Spliced Casein Kinase 1 Alpha Isoforms
ISBN: 0530005875 ISBN-13(EAN): 9780530005874
Издательство: Неизвестно
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Описание: Abstract:

Identify specific casein kinase I isoforms as neurofilament-associated kinases and elucidate their subcellular localization mechanism

Dissertation Discovery Company and University of Florida are dedicated to making scholarly works more discoverable and accessible throughout the world. This dissertation, "Characterization of Four Alternatively Spliced Casein Kinase 1 Alpha Isoforms" by Zheng Fu, was obtained from University of Florida and is being sold with permission from the author. A digital copy of this work may also be found in the university's institutional repository, IR@UF. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation.

Автор: Heribert Hirt
Название: MAP Kinases in Plant Signal Transduction
ISBN: 3642536921 ISBN-13(EAN): 9783642536922
Издательство: Springer
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Автор: Charles K Hester
Название: Mitogen-Activated Protein Kinases (MAPKs): Activation, Functions and Regulation
ISBN: 1536161381 ISBN-13(EAN): 9781536161380
Издательство: Nova Science
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Описание: Mitogen-Activated Protein Kinases (MAPKs): Activation, Functions and Regulation opens with a summary of the present knowledge about MAPK, with special emphasis on p38 and c-Jun Naterminal kinase. The authors focus on how these signaling pathways are engaged during some infections with intracellular parasites. The authors also describe selected regulatory aspects of circadian clocks in vertebrates, exploring an intriguing link to MAPK. Circadian clocks are time-tracking systems that provide organisms with a survival advantage. Cadmium, one of the toxic metals, is an important occupational and environmental pollutant that damages various organs, especially the kidney. The concluding study proposes that the type of kidney cell and severity of cadmium-induced cellular stress appear to determine the effect of MAPK on cell fate.

Автор: Inouye
Название: Histidine Kinases in Signal Transduction
ISBN: 0123724848 ISBN-13(EAN): 9780123724847
Издательство: Elsevier Science
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Цена: 26107.00 р.
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Описание: Living cells are constantly sensing environmental changes, and their abilities to sense these changes and adapt to them are essential for their survival. This book provides a review on the structure and function of histidine kinases. It also offers information on the physiological roles of histidine kinases in bacteria and eukaryotes.

Автор: Jenny, Andreas
Название: Protein Kinases in Development and Disease,123
ISBN: 0128015136 ISBN-13(EAN): 9780128015131
Издательство: Elsevier Science
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Protein Kinases in Development and Disease discusses and reviews important, but often neglected, kinases. A good representation of current model organisms from plants and C. elegans to mice are used as the basis to illustrate how we can use our understanding of normal development to learn about disease.

Автор: Serena Germano
Название: Receptor Tyrosine Kinases
ISBN: 1493954490 ISBN-13(EAN): 9781493954490
Издательство: Springer
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Описание:

Part I: RTKs Activation and Signalling

1. Analysis of Receptor Tyrosine Kinase (RTK) Phosphorylation by Immunoblotting

Martina McDermott and Norma O'Donovan

2. Analysis of Changes in Phosphorylation of Receptor Tyrosine Kinases: Antibody Arrays

Sweta Rani and Lorraine O'Driscoll

3. Analysis of Epidermal Growth Factor Receptor Dimerization by BS³ Crosslinking

Harmony F. Turk and Robert S. Chapkin

4. Single-Molecule Optical Methods Analyzing Receptor Tyrosine Kinase Activation in Living Cells

Inhee Chung and Ira Mellman

5. Evaluation of the Dimerization Profiles of HER Tyrosine Kinases by Time-Resolved Fцrster Resonance Energy Transfer (TR-FRET)

Evelyne Lopez-Crapez, Alexandre Ho-Pun-Cheung, Patrick Garnero, and Hervй Bazin

6. Applying the Proximity Ligation Assay (PLA) to Mouse Preimplantation Embryos for Identifying Protein-Protein Interactions In Situ

Ivan Bedzhov and Marc P. Stemmler

Part II: RTKs Aberrant Expression

7. Analysis of Receptor Tyrosine Kinase Gene Amplification on the Example of FGFR1

Diana Boehm, Anne von Mдssenhausen, and Sven Perner

8. Quantification of the Effects of Mutations on Receptor Tyrosine Kinase (RTK) Activation in Mammalian Cells

Lijuan He and Kalina Hristova

Part III: RTKs Trafficking and Negative Regulation

9. Cell Surface Biotinylation of Receptor Tyrosine Kinases to Investigate Intracellular Trafficking

Mathieu J.F. Crupi, Douglas S. Richardson, and Lois M. Mulligan

10. Studying N-Linked Glycosylation of Receptor Tyrosine Kinases

Harri M. Itkonen and Ian G. Mills

11. Identification of Receptor Protein Tyrosine Phosphatases (RPTPs) as Regulators of Receptor Tyrosine Kinases (RTKs) Using an RPTP siRNA-RTK Substrate Screen

Hojin Lee and Anton M. Bennett

12. Downregulation of Receptor Tyrosine Kinases Through Ubiquitination: Analysis by Immunodetection

Noriaki Shimokawa and Noriyuki Koibuchi

13. Regulation of Receptor Tyrosine Kinases by miRNA: Overexpression of miRNA Using Lentiviral Inducible Expression Vectors

XiangDong Le, Andrew T. Huang, Yunyun Chen, and Stephen Y. Lai

Part IV: RTKs as Pharmacological Targets

14. Human Tumor Xenografts in Mouse as a Model for Evaluating Therapeutic Efficacy of Monoclonal Antibodies or Antibody-Drug Conjugate Targeting Receptor Tyrosine Kinases

Liang Feng, Wei Wang, Hang-Ping Yao, Jianwei Zhou, Ruiwen Zhang, and Ming-Hai Wang

15. Receptor Tyrosine Kinase Targeting in Multicellular Spheroids

Susan Breslin and Lorraine O'Driscoll

16. Receptor Tyrosine Kinases and Drug Resistance: Development and Characterization of In Vitro Models of Resistance to RTK Inhibitors

Claire Corcoran and Lorraine O'Driscoll

Автор: Fisher, Paul B.
Название: Receptor Tyrosine Kinases,147
ISBN: 0128201428 ISBN-13(EAN): 9780128201428
Издательство: Elsevier Science
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Advances in Cancer Research, Volume 147, the latest release in this ongoing, well-regarded serial, provides invaluable information on the exciting and fast-moving field of cancer research in the area of Receptor Tyrosine Kinases (RTKs) in the context of major basic science and translational advances, its importance in the development of a large number of anti-cancer drugs over the decades, and a peek into postulated advances in the coming decades for a number of RTK. Chapters in this new release has been contributed by a group of International leading scientists with a rich history of original contributions to the field.