Physics at the Biomolecular Interface: Fundamentals for Molecular Targeted Therapy, Fernбndez Ariel
Автор: Fern?ndez Название: Physics at the Biomolecular Interface ISBN: 3319308513 ISBN-13(EAN): 9783319308517 Издательство: Springer Рейтинг: Цена: 20896.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This bookfocuses primarily on the role of interfacial forces in understanding biologicalphenomena at the molecular scale. By providing a suitable statisticalmechanical apparatus to handle the biomolecular interface, the book becomesuniquely positioned to address core problems in molecular biophysics. Ithighlights the importance of interfacial tension in delineating a solution tothe protein folding problem, in unravelling the physico-chemical basis ofenzyme catalysis and protein associations, and in rationally designingmolecular targeted therapies. Thus grounded in fundamental science, the bookdevelops a powerful technological platform for drug discovery, while it is setto inspire scientists at any level in their careers determined to address themajor challenges in molecular biophysics.Theacknowledgment of how exquisitely the structure and dynamics of proteins and theiraqueous environment are related attests to the overdue recognition thatbiomolecular phenomena cannot be effectively understood without dealing withinterfacial behaviour. There is an urge to grasp how biologically relevantbehaviour is shaped by the structuring of biomolecular interfaces and howinterfacial tension affects the molecular events that take place in the cell.This book squarely addresses these needs from a physicist perspective.Thebook may serve as a monograph for practitioners and, alternatively, as anadvanced textbook. Fruitful reading requires a background in physical chemistryand some basics in biophysics. The selected problems at the end of the chaptersand the progression in conceptual difficulty make it a suitable textbook for agraduate level course or an elective course for seniors majoring in chemistry,physics, biomedical engineering or related disciplines.
Описание: This book provides a comprehensive overview of modern computer-based techniques for analyzing the structure, properties and dynamics of biomolecules and biomolecular processes. It is organized in four main parts; the first one deals with methodology of molecular simulations; the second one with applications of molecular simulations; the third one introduces bioinformatics methods and the use of experimental information in molecular simulations; the last part reports on selected applications of molecular quantum mechanics. This second edition has been thoroughly revised and updated to include the latest progresses made in the respective field of research.
Автор: K. Nagata; H. Handa Название: Real-Time Analysis of Biomolecular Interactions ISBN: 4431669728 ISBN-13(EAN): 9784431669722 Издательство: Springer Рейтинг: Цена: 14365.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: At the Material Research Society Spring 2013 meeting, held in San Francisco April 1-5, 2013, three symposia were held focusing on thermal-to-electric energy conversion and thermal transport: Symposium H: Nanoscale Thermoelectrics - Materials and Transport Phenomena - II, Symposium I: Materials for Solid-State Refrigeration, and Symposium V: Nanoscale Heat Transport - From Fundamentals to Devices.
Описание: Understanding the functions and properties of molecules in living systems requires a detailed knowledge of their three-dimensional structures and the conformational variability that allows them to adopt multiple functional forms. Interpreting biological systems in the language of three-dimensional structures is of fundamental importance and innumerable research groups around the world are working in this area. This book is a compilation of articles describing attempts at understanding the intricacies of biological systems through the structures of and interactions between their constituent molecules.
Автор: Barrick Название: Biomolecular Thermodynamics: From Theory to Application ISBN: 1439800197 ISBN-13(EAN): 9781439800195 Издательство: Taylor&Francis Рейтинг: Цена: 17609.00 р. Наличие на складе: Поставка под заказ.
Описание: This book introduces the concepts and practical tools necessary to understand the behavior of biological macromolecules at a quantitative level, going beyond theory to explain in detail how the equations are applied to the analysis of experimental measurements. An emphasis on real-world applications is a continued throughout the book.
Автор: Anna Rita Bizzarri, Salvatore Cannistraro Название: Dynamic Force Spectroscopy and Biomolecular Recognition ISBN: 1138374520 ISBN-13(EAN): 9781138374522 Издательство: Taylor&Francis Рейтинг: Цена: 9492.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Molecular recognition, also known as biorecognition, is the heart of all biological interactions. Originating from protein stretching experiments, dynamic force spectroscopy (DFS) allows for the extraction of detailed information on the unbinding process of biomolecular complexes. It is becoming progressively more important in biochemical studies and is finding wider applications in areas such as biophysics and polymer science. In six chapters, Dynamic Force Spectroscopy and Biomolecular Recognition covers the most recent ideas and advances in the field of DFS applied to biorecognition: Chapter 1: Reviews the basic and novel aspects of biorecognition and discusses the emerging capabilities of single-molecule techniques to disclose kinetic properties and molecular mechanisms usually hidden in bulk measurements Chapter 2: Describes the basic principle of atomic force microsocopy (AFM) and DFS, with particular attention to instrumental and theoretical aspects more strictly related to the study of biomolecules Chapter 3: Overviews the theoretical background in which experimental data taken in nonequilibrum measurements of biomolecular unbinding forces are extrapolated to equilibrium conditions Chapter 4: Reviews the most common and efficient strategies adopted in DFS experiments to immobilize the interacting biomolecules to the AFM tip and to the substrate Chapter 5: Presents and discusses the most representative aspects related to the analysis of DFS data and the challenges of integrating well-defined criteria to calibrate data in automatic routinary procedures Chapter 6: Overviews the most relevant DFS applications to study biorecognition processes, including the biotin/avidin pair, and selected results on various biological complexes, including antigen/antibody, proteins/DNA, and complexes involved in adhesion processes Chapter 7: Summarizes the main results obtained by DFS applied to study biorecognition processes with forthcoming theoretical and experimental advances Although DFS is a widespread, worldwide technique, no books focused on this subject have been available until now. Dynamic Force Spectroscopy and Biomolecular Recognition provides the state of the art of experimental data analysis and theoretical procedures, making it a useful tool for researchers applying DFS to study biorecognition processes.
Автор: G. Vergoten; T. Theophanides Название: Biomolecular Structure and Dynamics ISBN: 9401063079 ISBN-13(EAN): 9789401063074 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the NATO Advanced Study Institute on Biomolecular Structure and Dynamics: Recent Experimental and Theoretical Advances, Loutraki, Greece, May 27-June 6, 1996
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