This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.
This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Автор: Kavanagh Название: Fungi: Biology and Applications 3e ISBN: 1119374324 ISBN-13(EAN): 9781119374329 Издательство: Wiley Рейтинг: Цена: 12081.00 р. 17258.00-30% Наличие на складе: Есть (1 шт.) Описание:
Fungi: Biology and Applications was first published in 2005 and since that date has sold over 1500 copies. The second edition was published in 2011 and has sold in excess of 750 copies and has also been translated into Turkish (total sales of two editions >2500 copies). This book has been extremely successful and is a recommended text in many third level institutions. The book is designed to appeal to undergraduate students and to those working with fungi for the first time (e.g. postgraduates, industrial scientists). Traditionally, fungal book have been very specific but this book provides chapters on a wide range of areas at a level sufficient for undergraduate and postgraduate study. For example chapters cover topics such as physiology, genetics, proteomics, medical mycology, plant pathology, genomic, and antifungal therapy. The provision of revision questions and extra reading at the end of each chapter also facilitates the learning process.
The third edition is warranted to take account of recent developments in a wide range of areas. For example new developments in proteomics and genomics are revolutionizing our understanding of fungi and their interaction with the environment and/or the host. Antifungal drug resistance is emerging as a major problem in the treatment of fungal infections. New fungal pathogens of plants are emerging as problems in temperate parts of the World due to the effect of climate change.
In addition to updating and revising the chapters in the second edition three new chapters will be included in the new edition: Fungi as food, Fungi and the immune response and Fungi in the environment. These further broaden the scope of the book.
An updated edition is now warranted to take account of recent developments in fungal biology. Many existing books in this area are subject specific whereas this book covers a wide range of topics. The addition of extra chapters in areas such as Fungi and food, Fungi and the immune system and Fungi in the environment broadens the appeal of the book and means that the reader now has a book covering all of the main areas of fungal biology thus making this book an essential addition to microbiology libraries. The book will be an excellent resource for undergraduate microbiology students and also for those working with fungi in Industry or Academia.
Название: Medical applications of artificial intelligence ISBN: 1138072273 ISBN-13(EAN): 9781138072275 Издательство: Taylor&Francis Рейтинг: Цена: 11789.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Enhanced, more reliable, and better understood than in the past, artificial intelligence (AI) systems can make providing healthcare more accurate, affordable, accessible, consistent, and efficient. However, AI technologies have not been as well integrated into medicine as predicted. In order to succeed, medical and computational scientists must develop hybrid systems that can effectively and efficiently integrate the experience of medical care professionals with capabilities of AI systems.
After providing a general overview of artificial intelligence concepts, tools, and techniques, Medical Applications of Artificial Intelligence reviews the research, focusing on state-of-the-art projects in the field. The book captures the breadth and depth of the medical applications of artificial intelligence, exploring new developments and persistent challenges.
Описание: This book introduces the emerging perspective of collision dynamics in mammalian terrestrial locomotion and explain how it influences the interpretation of form and functional capabilities. The coverage brings the reader to a sophisticated conceptual understanding of the relevant mechanics and the current debate ongoing in the field.
Описание: This textbook is aimed at newcomers to nonlinear dynamics and chaos, especially students taking a first course in the subject. The presentation stresses analytical methods, concrete examples, and geometric intuition. The theory is developed systematically, starting with first-order differential equations and their bifurcations.
Автор: Carter Название: Virology - Principles and Applications 2e ISBN: 1119991420 ISBN-13(EAN): 9781119991427 Издательство: Wiley Рейтинг: Цена: 8387.00 р. Наличие на складе: Поставка под заказ.
Описание: The second edition of Virology is an accessible introduction designed to enable students to understand the principles of virus structure, replication and genetics. The aim of this book is to help the reader appreciate the relevance of virology in the modern world, including the fields of vaccines, anti-viral drugs and cancer.
Автор: Burns Malcolm, Foster Lucy, Walker Michael Название: DNA Techniques to Verify Food Authenticity: Applications in Food Fraud ISBN: 1788011783 ISBN-13(EAN): 9781788011785 Издательство: Royal Society of Chemistry Рейтинг: Цена: 31469.00 р. Наличие на складе: Поставка под заказ.
Описание: Providing the most comprehensive and timely collection of material from those working at the forefront of DNA techniques applied to food authenticity, this book will appeal to food testing laboratories worldwide and food policy professionals and regulatory organisations who will be using these techniques to back up legislation and regulation.
Автор: Lieberman Jay R., Friedlaender Gary E. Название: Bone Regeneration and Repair / Biology and Clinical Applications ISBN: 0896038475 ISBN-13(EAN): 9780896038479 Издательство: Springer Рейтинг: Цена: 30745.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This collection of articles by leading orthopedic and craniofacial surgeons and researchers comprehensively reviews the biology of bone formation and repair, the basic science of autologous bone graft, allograft, bone substitutes, and growth factors, and explore their clinical application in patients with bone repair problems.
Описание: Biological and biomedical research are increasingly driven by experimental techniques that challenge our ability to analyse, process and extract meaningful knowledge from the underlying data. The impressive capabilities of next generation sequencing technologies, together with novel and ever evolving distinct types of omics data technologies, have put an increasingly complex set of challenges for the growing fields of Bioinformatics and Computational Biology. The analysis of the datasets produced and their integration call for new algorithms and approaches from fields such as Databases, Statistics, Data Mining, Machine Learning, Optimization, Computer Science and Artificial Intelligence. Clearly, Biology is more and more a science of information requiring tools from the computational sciences. In the last few years, we have seen the surge of a new generation of interdisciplinary scientists that have a strong background in the biological and computational sciences. In this context, the interaction of researchers from different scientific fields is, more than ever, of foremost importance boosting the research efforts in the field and contributing to the education of a new generation of Bioinformatics scientists. PACBB‘16 hopes to contribute to this effort promoting this fruitful interaction. PACBB'16 technical program included 21 papers spanning many different sub-fields in Bioinformatics and Computational Biology. Therefore, the conference will certainly promote the interaction of scientists from diverse research groups and with a distinct background (computer scientists, mathematicians, biologists). The scientific content will certainly be challenging and will promote the improvement of the work being developed by each of the participants.
Название: Gene delivery: methods and applications ISBN: 153616268X ISBN-13(EAN): 9781536162684 Издательство: Nova Science Рейтинг: Цена: 13462.00 р. Наличие на складе: Невозможна поставка.
Описание: Gene Delivery: Methods and Applications provides a comprehensive overview on viral and non-viral methods used to genetically engineer human mesenchymal stromal cells. In addition, an update on ongoing and completed clinical studies with engineered mesenchymal stromal cells will be provided, as well as a snapshot of the advances and technical challenges yet to be addressed. Next, a variety of gene delivery systems including physical transfection techniques, virus-based delivery vectors, chemically engineered delivery systems and bio-inspired vehicles are reviewed and their strengths, shortcomings and biomedical applications are discussed. Selfish DNA called transposons capable of cutting out and pasting into the host genome are active throughout the phylogenetic kingdoms. Researchers have repurposed natural transposons for use in delivering a gene-of-interest, enabling for the study of a large and growing list of preclinical gene therapy applications. As such, the authors discuss the past achievements and future challenges of this early-stage technology. The closing chapter introduces cell-penetrating peptides as an efficient tool for DNA transfection. HR9, a designed cell-penetrating peptides, containing nona-arginine flanked by cysteine and penta-histidine displayed a high penetrating ability in mammalian cells.
Описание: A unique book that summarizes the properties, toxicology, and biomedical applications of TiO2-based nanoparticles Nanotechnology is becoming increasingly important for products used in our daily lives. Nanometer-sized titanium dioxide (TiO2) are widely used in industry for different purposes, such as painting, sunscreen, printing, cosmetics, biomedicine, and so on. This book summarizes the advances of TiO2 based nanobiotechnology and nanomedicine, covering materials properties, toxicological research, and biomedical application, such as antibacter, biosensing, and cancer theranostics.
It uniquely integrates the TiO2 applications from physical properties, toxicology to various biomedical applications, and includes black TiO2 based cancer theranostics. Beginning with a comprehensive introduction to the properties and applications of nanoparticles, TiO2 Nanoparticles: Applications in Nanobiotechnology, Theranostics and Nanomedicine offers chapters on: Toxicity of TiO2 Nanoparticles; Antibacterial Applications of TiO2 Nanoparticles; Surface Enhanced Raman Spectrum of TiO2 Nanoparticle for Biosensing (TiO2 Nanoparticle Served as SERS Sensing Substrate); TiO2 as Inorganic Photosensitizer for Photodynamic Therapy; Cancer Theranostics of Black TiO2 Nanoparticles; and Neurodegenerative Disease Diagnostics and Therapy of TiO2-Based Nanoparticles. This title: -Blends the physical properties, toxicology of TiO2 nanoparticles to the many biomedical applications -Includes black TiO2 based cancer theranostics in its coverage -Appeals to a broad audience of researchers in academia and industry working on nanomaterials-based biosensing, drug delivery, nanomedicine TiO2 Nanoparticles: Applications in Nanobiotechnology, Theranostics and Nanomedicine is an ideal book for medicinal chemists, analytical chemists, biochemists, materials scientists, toxicologists, and those in the pharmaceutical industry.
Описание: This book focuses on state-of-the-art microfluidic research in medical and biological applications. The top-level researchers in this research field explain carefully and clearly what can be done by using microfluidic devices. Beginners in the field —undergraduates, engineers, biologists, medical researchers—will easily learn to understand microfluidic-based medical and biological applications. Because a wide range of topics is summarized here, it also helps experts to learn more about fields outside their own specialties. The book covers many interesting subjects, including cell separation, protein crystallization, single-cell analysis, cell diagnosis, point-of-care testing, immunoassay, embyos/worms on a chip and organ-on-a-chip. Readers will be convinced that microfluidic devices have great potential for medical and biological applications.
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