Cancer Drug Delivery Systems Based on the Tumor Microenvironment, Matsumura Yasuhiro, Tarin David
Автор: Ursini-Siegel Название: The Tumor Microenvironment ISBN: 1493937995 ISBN-13(EAN): 9781493937998 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book covers core and emerging in vitro and in vivo protocols used to study how various components of the tumor microenvironment are established and subsequently interact with tumor cells to facilitate carcinogenesis. In addition, the book examines research topics including cellular and molecular biology approaches, in vivo genetic approaches, various “omics”-based strategies, therapeutic strategies to target the microenvironment, and, finally, advanced techniques in the fields of tissue engineering and nanotechnology. Written and validated in the laboratories of a number of trusted collaborating authors for the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Practical and authoritative, The Tumor Microenvironment: Methods and Protocols constitutes a compendium of techniques now available to a broad audience, including basic and clinician scientists, systems biologists, and biological engineers.
Автор: Gianfranco Baronzio; Giammaria Fiorentini; Christo Название: Cancer Microenvironment and Therapeutic Implications ISBN: 1402095759 ISBN-13(EAN): 9781402095757 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Explores cancer micro environments and host interactions. This book is suitable for clinical oncologists, clinical hematologists, research oncologists, research hematologists, immunologists, stem cell researchers, oncology and hematology fellows (trainees).
Автор: Rejniak Название: Systems Biology of Tumor Microenvironment ISBN: 3319420216 ISBN-13(EAN): 9783319420219 Издательство: Springer Рейтинг: Цена: 22203.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This edited volume discusses the complexity of tumor microenvironments during cancer development, progression and treatment. Each chapter presents a different mathematical model designed to investigate the interactions between tumor cells and the surrounding stroma and stromal cells. The topics covered in this book include the quantitative image analysis of a tumor microenvironment, the microenvironmental barriers in oxygen and drug delivery to tumors, the development of tumor microenvironmental niches and sanctuaries, intravenous transport of the circulating tumor cells, the role of the tumor microenvironment in chemotherapeutic interventions, the interactions between tumor cells, the extracellular matrix, the interstitial fluid, and the immune and stromal cells. Mathematical models discussed here embrace both continuous and agent-based approaches, as well as mathematical frameworks of solid mechanics, fluid dynamics and optimal control theory. The topics in each chapter will be of interest to a biological community wishing to apply the mathematical methods to interpret their experimental data, and to a biomathematical audience interested in exploring how mathematical models can be used to address complex questions in cancer biology.
Описание: The tumor microenvironment has become a very important and hot topic in cancer research within the past few years. The tumor microenvironment is defined as the normal cells, molecules, and blood vessels that surround and feed a tumor cell. As many scientists have realized, studying the tumor microenvironment has become critical to moving the field forward, since there are many players in a tumor’s localized and surrounding area, which can significantly change cancer cell behavior. There is a dual relationship wherein the tumor can change its microenvironment and the microenvironment can affect how a tumor grows and spreads. Tumor Microenvironment in Cancer Progression and Cancer Therapy aims to shed light on the mechanisms, factors, and mediators that are involved in the cancer cell environment. Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics. Thus, the dual role of the tumor microenvironment is the integral focus of the volume. The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. It also focuses on the three groups of the reactive tumor component: stromal cells, blood vessels and the infiltrating immune cells. These three groups are discussed under the lens of their role in promoting tumor growth, shielding the tumor from rejection and from standard forms of cancer therapies. They are emerging as targets and mediators of standard and new forms of potential therapy.
Описание: Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics.
Автор: Andrei Thomas-Tikhonenko Название: Cancer Genome and Tumor Microenvironment ISBN: 1461425247 ISBN-13(EAN): 9781461425243 Издательство: Springer Рейтинг: Цена: 36570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: There exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. The reviews in this book explore in detail how tumor microenvironment and progression are "hard-wired" at the genetic level.
Автор: Baronzio Название: Cancer Microenvironment and Therapeutic Implications ISBN: 9048181607 ISBN-13(EAN): 9789048181605 Издательство: Springer Рейтинг: Цена: 20896.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book examines cancer microenvironments and host interactions with an eye towards exploiting our understanding for new treatments. The team of contributors share amongst them impressive experiences at the laboratory bench and in the clinic.
1 The genomic complexity of osteosarcoma and its implication for preclinical and clinical targeted therapies
2 Genomics and the Immune Landscape of Osteosarcoma
3 RECQ DNA Helicases and Osteosarcoma
4 Targeting the Cancer Epigenome with Histone Deacetylase Inhibitors in Osteosarcoma
5 Oncolytic viruses and their potential as a therapeutic opportunity in Osteosarcoma
6 Applying Osteosarcoma Immunology to Understand Disease Progression and Assess immunotherapeutic Response
7 Targetable intercellular signaling pathways facilitate lung colonization in osteosarcoma
8 Wnt Signaling in Osteosarcoma
9 Receptor Tyrosine Kinases in Osteosarcoma: 2019 update
10 The Role of ALDH in the Metastatic Potential of Osteosarcoma Cells and Potential ALDH Targets
11 Autophagy in OS
12 Fas signaling as a potential target for the treatment of osteosarcoma metastasis in the lungs
13 Exosomes: Dynamic Mediators of Extracellular Communication in the Tumor Microenvironment
14 Comparative Immunology and Immunotherapy of Canine Osteosarcoma
Index
Автор: Birbrair Alexander Название: Tumor Microenvironment: Recent Advances ISBN: 3030357260 ISBN-13(EAN): 9783030357269 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: 1. Novel techniques to study the bone-tumor microenvironment2. An emerging model for cancer development from a tumor microenvironment perspective in mice and humans3. Effects of Exercise on the Tumour Microenvironment4. Effects of inhaled tobacco smoke on the pulmonary tumor microenvironment5. Multimodal molecular imaging of the tumour microenvironment6. Necrosis in the tumor microenvironment and its role in cancer recurrence7. The Multifaceted Effects of Autophagy on the Tumor Microenvironment8. The Sociobiology of Brain Tumors9. Tumor microenvironment conditioning by abortive lytic replication of oncogenic γ-herpesviruses10. The microbiome as a component of the tumor microenvironmentIndex
Автор: Yefenof Название: Innate and Adaptive Immunity in the Tumor Microenvironment ISBN: 9048177138 ISBN-13(EAN): 9789048177134 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Recent studies, however, indicate that the tumor microenvironment is unique in providing both supportive and inhibitory factors that determine the fate of the tumor and its host.
Автор: Birbrair Alexander Название: Tumor Microenvironment: State of the Science ISBN: 3030445178 ISBN-13(EAN): 9783030445171 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A variety of topics are covered, including metabolism in the tumor microenvironment, stellate cells and endothelial progenitors in the tumor microenvironment, as well as the effects of HIV, viral hepatitis, and inflammation in the tumor microenvironment, and more.
Автор: Lekin Sandra Название: Breast Cancer: Tumor Microenvironment and Biology ISBN: 1632410680 ISBN-13(EAN): 9781632410689 Издательство: Неизвестно Цена: 20108.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The causes of cancer are diversified. Cancer is the principal reason of death in the majority of countries and it results in enormous financial, societal and mental burden. Breast cancer is the most diagnosed kind of cancer and the foremost reason of deat
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