Monoclonal Antibodies in Headache: From Bench to Patient, Maassen Van Den Brink Antoinette, Martelletti Paolo

Автор: Kresina
Название: Monoclonal Antibodies
ISBN: 0824781163 ISBN-13(EAN): 9780824781163
Издательство: Taylor&Francis
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Описание: Presents a sampling of new and novel approaches to the amelioration of musculoskeletal disease pathology, emphasizing prevention and therapy. Where applicable, these new technologies are focused on their application to human autoimmune diseases, but the volume mainly discusses and details the use of

Автор: Dirk J. Ruiter; G.J. Fleuren; S.O. Warnaar
Название: Application of Monoclonal Antibodies in Tumor Pathology
ISBN: 9401079811 ISBN-13(EAN): 9789401079815
Издательство: Springer
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Описание: The development of monoclonal antibodies to human tumor associated antigens has greatly facilitated the application of immunohistochemical techniques to analyze surgically removed tissues. During the last few years this approach has been utilized by a progressively increasing number of investigators to analyze malignant cells. Although monoclonal antibodies to tumor associated antigens have not become yet routine reagents in immunopathology, they have provided new information which could not be obtained with conventional antisera or histochemical procedures. The following are representative examples. TUmor associated antigens have been identified which display a restricted distribution in normal tissues and therefore may represent useful markers for radio­ imaging and appropriate targets for immunotherapy. In spite of undetec­ table differences with conventional histopathological approaches hetero­ geneity has been found in the antigenic profile of tumor cells within a lesion, in autologous lesions removed from different anatomic sites from a given patient and in lesions removed from different patients. Phenotypes of tumor cells have been identified which correlate with the biology of tumor cells and with the clinical course of the disease. From a practical view point the use of monoclonal antibodies in immunopathology has enhanced interactions between pathologists and immunologists, as exemplified by the present book. Such interactions have contributed to the application of basic research to clinical problems. The chapter of this book discuss investigations performed with monoclonal antibodies to antigens expressed by various types of normal and malignant human cells.

Автор: Albitar Maher
Название: Monoclonal antibodies / methods and protocols
ISBN: 1588295672 ISBN-13(EAN): 9781588295675
Издательство: Springer
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Описание: Monoclonal Antibodies: Methods and Protocols examines a collection of state-of-the-art methods that employ monoclonal antibodies in a clinical setting with opening chapters focusing on the gold standard method for generating mouse monoclonal antibodies through hybridoma technology, future methods for engineering recombinant and humanized antibodies, methods for engineering soluble Fc fusion protein, and the use of antibodies and flow cytometry in the quantification of cell signaling proteins. Specific chapters describe how antibodies are used for the diagnosis and classification of hematologic diseases. Subsequent chapters examine the advantages and most recent advances of using bead-based immunoassays, including the ability of bead-based technology to multiplex and analyze several analytes simultaneously, and the use of beads in detecting fusion proteins resulting from chromosomal translocations. Concluding chapters provide additional examples of methodologies that employ monoclonal antibodies.Monoclonal Antibodies: Methods and Protocols provides descriptions of methods that cover a wide spectrum of applications in the field of monoclonal antibodies. This field will continue to expand and provide new and innovative techniques, not only in the laboratory, but also as a basis that complements targeted therapy.

Автор: Zhiquang
Название: Therapeutic Monoclonal Antibodies: From Bench to Clinic
ISBN: 0470117915 ISBN-13(EAN): 9780470117910
Издательство: Wiley
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Описание: 70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety.

Автор: Roger H. Kennett
Название: Monoclonal Antibodies
ISBN: 1461575079 ISBN-13(EAN): 9781461575078
Издательство: Springer
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Описание: On August 7, 1975, Kohler and Milstein published in Nature (256:495) a report describing Continuous cultures of fused cells secreting antibody of predefined specificity. Their report has become a classic and has already had a profound effect on basic and applied research in biology and medicine. By the time the first Workshop on Lymphocyte Hybridomas (Current Topics in Microbiology and Im- munology 81, 1978) was held on April 3-5, 1978, in Bethesda, Maryland, investi- gators from many laboratories had made hybrids between plasmacytomas and spleen cells from immunized animals and had obtained monoclonal antibodies reacting with a broad variety of antigenic determinants. At the time Kohler and Milstein introduced this new technology, the editors of this volume were involved in the production of antisera against differentiation antigens (K. B. B. ), histocompatibility antigens (T. ]. McK. ), and human tumor- associated antigens (R. H. K. ). Because of the potential usefulness of monoclonal antibodies in these areas, we each began production of hybridomas and analysis of the resulting monoclonal reagents. One of the most interesting aspects of participation in the early stages of the development and application of hybrid- oma technology has been observing how the implications of the initial observa- tions gradually spread first among the practitioners of immunology and immu- nogenetics, and then to other areas of the biological sciences, such as developmental biology, biochemistry, human genetics, and cell and tumor biology.

Автор: Wick
Название: Monoclonal Antibodies in Diagnostic Immunohistochemistry
ISBN: 0824778383 ISBN-13(EAN): 9780824778385
Издательство: Taylor&Francis
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Описание: This book describes the methodology of monoclonal antibody-mediated immunohistochemistry, as applied to practical tissue diagnosis. It focuses on human disease and discusses the spectrum of monoclonal antibodies in relation to its utility in solving differential diagnostic problems.

Автор: M.F. Greaves
Название: Monoclonal Antibodies to Receptors
ISBN: 9401089558 ISBN-13(EAN): 9789401089555
Издательство: Springer
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Автор: Bazin
Название: Revival: Rat Hybridomas and Rat Monoclonal Antibodies (1990)
ISBN: 1138561649 ISBN-13(EAN): 9781138561649
Издательство: Taylor&Francis
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Описание: The purpose of this book is to provide information which supports the fact that rat hybridomas are no more difficult to develop than mouse hybridomas. This is the first book devoted to the development of rat hybridomas. It includes theories, step-by-step techniques, ingredients and apparatus.

Автор: Lucienne Chatenoud
Название: Monoclonal Antibodies in Transplantation
ISBN: 3662221977 ISBN-13(EAN): 9783662221976
Издательство: Springer
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Описание: Experimental and clinical evidence presented in this book illustrates that antibodies expressing different specificities can be very effective in preventing or reversing established transplant rejection.

Автор: R. Ceriani
Название: Monoclonal Antibodies and Breast Cancer
ISBN: 1461296374 ISBN-13(EAN): 9781461296379
Издательство: Springer
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Описание: Proceedings of the International Workshop on Monoclonal Antibodies and Breast Cancer, held in San Francisco, California, November 8-9, 1984

Автор: Stewart Sell; Ralph Reisfeld
Название: Monoclonal Antibodies in Cancer
ISBN: 146129598X ISBN-13(EAN): 9781461295983
Издательство: Springer
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Описание: This represents the third volume in a series on cancer markers pub- lished by the Humana Press. The first volume, published in 1980, stressed the relationship of development and cancer as reflected in the production of markers by cancer that are also produced by normal cells during fetal development. The concept that cancer represents a problem of differentiation was introduced by Barry Pierce in describing differenti- ation of teratocarcinomas. Highlighted were lymphocyte markers, alphafetoprotein, carcinoembryonic antigen, ectopic hormones, enzymes and isozymes, pregnancy proteins, and fibronectin. The second volume, published in 1982 and coedited with Britta Wahren, focused on the diagnostic use of oncological markers in human cancers, which were systematically treated on an organ by organ basis. At that time, the application of monoclonal antibodies to the identification of cancer markers was still in a very preliminary stage. A general introduc- tion to monoclonal antibodies to human tumor antigens was given there by William Raschke, and other authors included coverage of those mark- ers then detectable by monoclonal antibodies in their chapters.

Автор: Ron Hubbard; Vincent Marks
Название: Clinical Applications of Monoclonal Antibodies
ISBN: 1461288614 ISBN-13(EAN): 9781461288619
Издательство: Springer
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Описание: Immunology has come a long way in the hundred or so years since the general concepts were first enuciated by Metchnikoff, Ehrlich, Von Bebring and others, One of the landmarks in this progress was the invention and development of monoclonal antibody secreting hybridomas by Milstein and bis co-workers in Cambridge.