Описание: This best-selling undergraduate textbook introduces the key experimental techniques from across the biosciences. It uniquely integrates the theories and methods driving the fields of biology and medicine, comprehensively covering both the techniques that students will encounter in lab classes and those that underpin recent advances and discoveries.
Автор: Fu Haian Название: Protein-Protein Interactions / Methods and Applications ISBN: 1588291200 ISBN-13(EAN): 9781588291202 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A collection of highly successful biochemical, biophysical, genetic, and computational techniques for studying protein-protein interactions. These readily reproducible methods demonstrate how to identify protein interaction partners, qualitatively or quantitatively measure protein-protein interactions in vitro or in vivo, monitor protein-protein interactions as they occur in living cells, and determine interaction interfaces. The techniques described utilize a variety of cutting-edge technologies, including surface plasmon resonance (SRP), fluorescence resonance energy transfer (FRET), fluorescence polarization (FP), isothermal titration calorimetry (ITC), circular dichroism (CD), protein fragment complementation assays (PCA), various two-hybrid systems, and proteomics and bioinformatics-based approaches, such as the Scansite program for computational analysis. These powerful tools are essential for deciphering how proteins interact with each other to form biological networks, as well as for unraveling protein-protein interactions in disease to find novel therapeutic targets.
Автор: Anna Panchenko; Teresa M. Przytycka Название: Protein-protein Interactions and Networks ISBN: 1849967318 ISBN-13(EAN): 9781849967310 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The biological interactions of living organisms, and protein-protein interactions in particular, are astonishingly diverse.
Автор: Michael D. Wendt Название: Protein-Protein Interactions ISBN: 3642439551 ISBN-13(EAN): 9783642439551 Издательство: Springer Рейтинг: Цена: 39182.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Protein-Protein Interactions as Drug Targets.- Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapeutics.- The Development of Small-Molecule IAP Antagonists for the Treatment of Cancer.- Protein-Protein Interaction Targets to Inhibit HIV-1 Infection.- Inhibitors of Protein-Protein Interactions in Paramyxovirus Fusion - a Focus on Respiratory Syncytial Virus.- Rational Design Strategies for Developing Synthetic Inhibitors of Helical Protein Interfaces.- The Discovery of Navitoclax, a Bcl-2 Family Inhibitor.
Описание: This thesis focuses on the study of interactions between protein and peptides and their potential applications in cell imaging and nanoparticle surface modification. Drawing inspiration from naturally occurring coiled-coil binding pairs, it proposes a novel covalent peptide tag and probe system, based on the concept of “affinity guided covalent conjugation.” This newly established methodology provides complementary resolution to protein labeling, imaging and trafficking. By systematically investigating the coordination interaction between protein and quantum dots using various engineered protein ligands, this thesis proposes a general rule for protein self-assembly on the surface of quantum dots and reports a revolutionized nanobelt protein in accordance with this rule. It is an extraordinary example of interdisciplinary research, providing answers to real-life biological problems from a chemistry perspective.
Автор: Marvin Jens Название: Dissecting Regulatory Interactions of RNA and Protein ISBN: 3319070819 ISBN-13(EAN): 9783319070810 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The work described in this book is an excellent example of interdisciplinary research in systems biology. It shows how concepts and approaches from the field of physics can be efficiently used to answer biological questions and reports on a novel methodology involving creative computer-based analyses of high-throughput biological data. Many of the findings described in the book, which are the result of collaborations between the author (a theoretical scientist) and experimental biologists and between different laboratories, have been published in high-quality peer-reviewed journals such as Molecular Cell and Nature. However, while those publications address different aspects of post-transcriptional gene regulation, this book provides readers with a complete, coherent and logical view of the research project as a whole. The introduction presents post-transcriptional gene regulation from a distinct angle, highlighting aspects of information theory and evolution and laying the groundwork for the questions addressed in the subsequent chapters, which concern the regulation of the transcriptome as the primary functional carrier of active genetic information.
Автор: Joseph Yariv Название: The Discreet Charm of Protein Binding Sites ISBN: 3319249940 ISBN-13(EAN): 9783319249940 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is a passionate account of the scientific breakthroughs that led to the solution of the first protein structures and to the understanding of their function at atomic resolution. The book is divided into self-standing chapters that each deal with a protein or protein family.
Описание: This book has been conceives as a brief introduction to biomembranes physical chemistry for undergraduate students of sciences, and it is particularly dedicated to the lipid-protein membrane interactions.
Автор: Donev, Rossen Название: Protein-Protein Interactions in Human Disease, Part B ISBN: 0128143428 ISBN-13(EAN): 9780128143421 Издательство: Elsevier Science Рейтинг: Цена: 20043.00 р. Наличие на складе: Нет в наличии.
Описание:
Protein-Protein Interactions in Human Disease, Volume 111, Part B, promotes further research and development in the protein interaction network in order to identify critical proteins involved in the etiology of human diseases and locate new protein targets for drug development. Thus, this volume is of considerable interest to protein chemists, pharmacologists, cell biologists, immunologists, structural biologists, computational biochemists and other researchers working in the field. In addition, these articles would be of great benefit to medical, biology and pharmacology students who specialize in this field.
Describes advances in the application of powerful techniques in studying and analyzing protein-protein interactions
Ideal for a wide audience of researchers, specialists and students
Written by authorities in their field
Contains a number of high quality illustrations, figures and tables that support the presented information
Автор: Gabriel Waksman Название: Proteomics and Protein-Protein Interactions ISBN: 1489996117 ISBN-13(EAN): 9781489996114 Издательство: Springer Рейтинг: Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Gabriel Waksman Institute of Structural Molecular Biology, Birkbeck and University College London, Malet Street, London WC1E 7HX, United Kingdom Address for correspondence: Professor Gabriel Waksman Institute of Structural Molecular Biology Birkbeck and University College London Malet Street London WC1E 7H United Kingdom Email: g.
Автор: Tom Moss; Beno?t Leblanc Название: DNA-Protein Interactions ISBN: 1617378755 ISBN-13(EAN): 9781617378751 Издательство: Springer Рейтинг: Цена: 25853.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Gene expression can mean the difference between health and disease, the difference between survival and starvation. This third edition brings this vital subject up to date with protocols exploring the most cutting-edge developments in the field.
Автор: Schueler-Furman, Ora;London, Nir Название: Modeling Peptide-Protein Interactions : Methods and Protocols ISBN: 1493967967 ISBN-13(EAN): 9781493967964 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume covers an array of techniques available for studying peptide-protein docking and design.
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