Advances in Translational Neuroscience of Eye Movement Disorders, Shaikh Aasef, Ghasia Fatema
Автор: Argyropoulos Georgios P. D. Название: Translational Neuroscience of Speech and Language Disorders ISBN: 3030356868 ISBN-13(EAN): 9783030356866 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides the first presentation of the state-of-the-art in the application of modern Neuroscience research in predicting, preventing and alleviating the negative sequelae of neurodevelopmental, acquired, or neurodegenerative brain abnormalities on speech and language.
Описание: Neurodegeneration is a key feature of several diseases that are referred to as neurodegenerative diseases. The process of neurodegeneration is not well-understood so the diseases that stem from it have, as yet, no cures. As such, studying the effects of these disorders can provide insight into the treatment, prevention, and future opportunities and challenges in this growing field.The Handbook of Research on Critical Examinations of Neurodegenerative Disorders is a critical scholarly resource that provides an extensive explanation of various neurodegenerative disorders based on existing studies to clarify etiology, pathological mechanisms, diagnosis, therapeutic interventions, as well as current status and future opportunities and challenges. Featuring coverage on a broad range of topics such as dementia, mitochondrial dysfunction, and risk factors, this book is geared towards neurobiologists, neuropsychologists, neurophysiologists, neuropathologists, medical professionals, academicians, and researchers seeking research on the complexity of neurodegenerative disorders.
Описание: A comprehensive book that reviews advances in ocular motor research on topics of general interest, rare, specialized or unique conditions, and pertinent basic neuroscience. A rare collection with contributions from basic neuroscientists, neurologists, and ophthalmologists. Includes dedicated chapters on mathematical models, pharmacotherapy, neuromodulation, motion perception, visual influence on eye movement, physiology of strabismus, and microsaccades. This book is dedicated to David Robinson - one of the pioneers of contemporary ocular motor and vestibular neuroscience.
Автор: Argyropoulos Georgios P. D. Название: Translational Neuroscience of Speech and Language Disorders ISBN: 3030356892 ISBN-13(EAN): 9783030356897 Издательство: Springer Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides the first presentation of the state-of-the-art in the application of modern Neuroscience research in predicting, preventing and alleviating the negative sequelae of neurodevelopmental, acquired, or neurodegenerative brain abnormalities on speech and language.
Chapter 19 - Discovery of Potent Gamma Secretase Modulators for the Treatment of Alzheimer's Disease - Kevin D. Rynearson, Rudolph E. Tanzi and Steven L. Wagner
Chapter 20 - Blocking the Nogo-A signalling pathway to promote regeneration and pla
sticity after spinal cord injury and stroke - tachment: initial; background-size: initial; background-origin: initial; background-clip: initial; background-position: initial; background-repeat: initial;">Anna Magdalena Guzik-Kornacka, Flуra Vajda, Martin E. Schwab
Chapter 21 - Intrinsic neuronal mechanisms in axon regeneration after spinal cord injury - Fengfeng Bei and Zhigang He
Chapter 22 - Voltage-gated ion channels as molecula
r targets for pain - Gerald W. Zamponi, Chongyang Hanand Stephen G. Waxman
Section 4: Activity-Dependent Plasticity and Neurorehabilitation
Chapter 24 - Neural Prostheses for Neurotrauma - Arthur Prochazka
Chapter 25 - Why is Fu
nctional Electrical Stimulation Therapy Capable of Restoring Motor Function Following Severe Injury to the Central Nervous System? - Mary K. Nagai, Cesar Marquez-Chin and Milos R. Popovic
Chapter 26 - Deep Brain Stimulation for Neuropsychiatric Disorders - Ausaf A. Bari, Nicolas Kon Kam King, Nir Lipsman and Andres M. Lozano
Chapter 27 - Novel Interventions for Stroke: Nervous System Cooling - Patrick D. Lyden, Jessica Lamb and Padmesh S. Rajput
A critical examination of translational medicine, when private risk is transferred to the public sector and university research teams become tech startups for global investors.
A global shift has secretly transformed science and medicine. Starting in 2003, biomedical research in the West has been reshaped by the emergence of translational science and medicine--the idea that the aim of research is to translate findings as quickly as possible into medical products. In The Market in Mind, Mark Dennis Robinson charts this shift, arguing that the new research paradigm has turned university research teams into small biotechnology startups and their industry partners into early-stage investment firms. There is also a larger, surprising consequence from this shift: according to Robinson, translational science and medicine enable biopharmaceutical firms, as part of a broader financial strategy, to outsource the riskiest parts of research to nonprofit universities. Robinson examines the implications of this new configuration. What happens, for example, when universities absorb unknown levels of risk? Robinson argues that in the years since the global financial crisis translational science and medicine has brought about "the financialization of health."
Robinson explores such topics as shareholder anxiety and industry retreat from Alzheimer's and depression research; how laboratory research is understood as health innovation even when there is no product; the emergence of investor networking events as crucial for viewing science in a market context; and the place of patients in research decisions. Although translational medicine justifies itself by the goal of relieving patients' suffering, Robinson finds patients' voices largely marginalized in translational neuroscience.
Описание: This case series book offers a practical and accessible approach to psychiatry, addressing major clinical problems ranging from psychosis to aging effects, each of which is tackled as it arises in everyday settings.
Описание: This volume highlights proteomics studies of quantitative PTM changes in both peripheral and central nervous system proteomes utilizing the most recent advances in mass spectrometry. Chapters include practical information pertaining to the fundamentals of sample preparation, liquid chromatography, and tandem mass spectrometry instrumental analysis and will elucidate best practices in the interpretation of data using modern bioinformatics approaches. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.Authoritative and practical, Analysis of Post-Translational Modifications and Proteolysis in Neuroscience aims to ensure successful results in the further study of this vital field.
Название: Translational neuroscience ISBN: 1489976523 ISBN-13(EAN): 9781489976529 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Поставка под заказ.
Описание:
Chapter 1 - Introduction - Mark H. Tuszynski
Section 1: Molecular Approaches
Chapter 2 - Gene Therapy of CNS Disorders using Recombinant AAV vectors - Giridhar Murlidharan, R. Jude Samulski and Aravind Asokan
Chapter 3 - NGF and BDNF Gene Therapy for Alzheimer's Disease - Alan H. Nagahara and Mark H. Tuszynski
Chapter 4 - GDNF and AADC Gene Therapy for Parkinson's Disease - Krystof Bankiewicz, Waldy San Sebastian, Lluis Samaranch and John Forsayeth
Chapter 5 - GAD Gene Therapy for Parkinson's Disease - Michael G. Kaplitt and Matthew J. During
Chapter 6 - Anti-sense Oligonucleotides
for Amyotrophic Lateral Sclerosis - Wade K. Self and Timothy M. Miller
Chapter 7 - Gene therapy for Inborn Errors of Metabolism: Batten Disease - Dolan Sondhi, Ronald G. Crystal and Stephen M. Kaminsky
Chapter 8 - Gene Therapy for Spinal Cord Injury - Ioana Goganau and Armin Blesch
Chapter 9 - Gene Therapy for Epilepsy - Thomas J. McCown
Chapter 10 - Gene therapy for Pain - Darren Wolfe, David Krisky, James Goss, James Wechuck, Marina Mata and David J. Fink
Section 2: Cellular Approaches
Chapter 11 - Stem Cells for Parkinson's Disease - Andrйs Bratt-Lealand Jeanne F. Loring
quot;serif"">Chapter 12 - Could Stem Cells be used to treat or model Alzheimer's Disease? - Edsel M. Abud and Mathew Blurton-Jones
Chapter 13 - Stem cells for Amyotrophic Late
ral Sclerosis - Anthony Donsante, Lindsey Nicole Urquia and Nicholas M. Boulis
Chapter 14 - Stem cells for Multiple Sclerosis - Pamela Sarkar and Neil Scolding
Chapter 15 - Cell Therapy for Pediatric Disorders of Glia - Joana M. Osorio and Steven A. Goldman
Chapter 16 - Neural Stem Cells for Spinal Cord Injury - Paul Lu, Ruhel Amhad
le="mso-bidi-font-size:12.0pt;font-family: "Times New Roman","serif""> and Mark H. Tuszynski
Chapter 17 - Marrow-derived Mesenchymal Stromal Cells in the Treatment of Stroke - Steve C. Cramer
Chapter 19 - Discovery of Potent Gamma Secretase Modulators for the Treatment of Alzheimer's Disease - Kevin D. Rynearson, Rudolph E. Tanzi and Steven L. Wagner
Chapter 20 - Blocking the Nogo-A signalling pathway to promote regeneration and pla
sticity after spinal cord injury and stroke - tachment: initial; background-size: initial; background-origin: initial; background-clip: initial; background-position: initial; background-repeat: initial;">Anna Magdalena Guzik-Kornacka, Flуra Vajda, Martin E. Schwab
Chapter 21 - Intrinsic neuronal mechanisms in axon regeneration after spinal cord injury - Fengfeng Bei and Zhigang He
Chapter 22 - Voltage-gated ion channels as molecula
r targets for pain - Gerald W. Zamponi, Chongyang Hanand Stephen G. Waxman
Section 4: Activity-Dependent Plasticity and Neurorehabilitation
Chapter 24 - Neural Prostheses for Neurotrauma - Arthur Prochazka
Chapter 25 - Why is Fu
nctional Electrical Stimulation Therapy Capable of Restoring Motor Function Following Severe Injury to the Central Nervous System? - Mary K. Nagai, Cesar Marquez-Chin and Milos R. Popovic
Chapter 26 - Deep Brain Stimulation for Neuropsychiatric Disorders - Ausaf A. Bari, Nicolas Kon Kam King, Nir Lipsman and Andres M. Lozano
Chapter 27 - Novel Interventions for Stroke: Nervous System Cooling - Patrick D. Lyden, Jessica Lamb and Padmesh S. Rajput
Chap
Автор: Conn, P. Michael Название: Conn`s Translational Neuroscience ISBN: 0128023813 ISBN-13(EAN): 9780128023815 Издательство: Elsevier Science Рейтинг: Цена: 20212.00 р. Наличие на складе: Поставка под заказ.
Описание:
Conn's Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain, ' with the results providing insight into the underlying basis of many neurological disease processes.
This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis.
In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn's Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance.
Автор: Ghiso Jorge A, Rostagno Agueda A Название: Protein Folding Disorders Of The Central Nervous System ISBN: 9813222956 ISBN-13(EAN): 9789813222953 Издательство: World Scientific Publishing Рейтинг: Цена: 22018.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This exciting new book explores the dark side of the molecular protein assembly bringing an updated view of how failures in the homeostatic mechanisms that efficiently regulate protein folding leads to the accumulation of structurally abnormal pathogenic assemblies, encompassing an emerging group of diseases collectively known as "Protein Folding Disorders." This complex and diverse group of chronic and progressive entities are bridged together by their relationship to structural transitions in the native state of specific proteinaceous components, which for reasons poorly understood, convert into polymeric aggregates that generate poorly soluble tissue deposits and which are considered today the culprit of the disease pathogenesis in their respective diseases. Despite the diversity in the amino acid sequence of the different proteins involved in these heterogeneous disorders, all the pathologic conformers can trigger cascades of events ultimately resulting in cell dysfunction and death with devastating clinical consequences in many of the most precious aspects of human existence including personality, cognition, memory, and skilled movements.
This book, which is composed of a compilation of chapters authored by outstanding and well-published scientists in the respective fields currently performing active investigations at world renowned universities and research centers, focuses on the growing number of diseases associated with protein misfolding in the central nervous system. Individual chapters are dedicated to the most common neurodegenerative diseases associated with protein aggregation/fibrillization focusing on the nature of the pathogenic species and the cellular pathways involved in the molecular pathogenesis of Alzheimer's, Parkinson's, and Huntington's diseases as well as in Amyotrophic Lateral Sclerosis, and Prion disorders. A group of contributions is centered on the current knowledge of the intracellular pathways and subcellular organelles affected by the different disease conditions, while others are focused in the emerging pathogenic role of misfolded subunits assembled into neurotoxic soluble oligomers, and in the novel notion of the transmissibility of the protein misfolded species, an innovative concept until recently only accepted for Prion diseases. Lastly, a different set of chapters is dedicated to the evaluation of novel therapeutic strategies for these devastating diseases.
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