Описание: A comprehensive book that reviews advances in ocular motor research on topics of general interest, rare, specialized or unique conditions, and pertinent basic neuroscience. A rare collection with contributions from basic neuroscientists, neurologists, and ophthalmologists. Includes dedicated chapters on mathematical models, pharmacotherapy, neuromodulation, motion perception, visual influence on eye movement, physiology of strabismus, and microsaccades. This book is dedicated to David Robinson - one of the pioneers of contemporary ocular motor and vestibular neuroscience.
Автор: Argyropoulos Georgios P. D. Название: Translational Neuroscience of Speech and Language Disorders ISBN: 3030356892 ISBN-13(EAN): 9783030356897 Издательство: Springer Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides the first presentation of the state-of-the-art in the application of modern Neuroscience research in predicting, preventing and alleviating the negative sequelae of neurodevelopmental, acquired, or neurodegenerative brain abnormalities on speech and language.
Chapter 19 - Discovery of Potent Gamma Secretase Modulators for the Treatment of Alzheimer's Disease - Kevin D. Rynearson, Rudolph E. Tanzi and Steven L. Wagner
Chapter 20 - Blocking the Nogo-A signalling pathway to promote regeneration and pla
sticity after spinal cord injury and stroke - tachment: initial; background-size: initial; background-origin: initial; background-clip: initial; background-position: initial; background-repeat: initial;">Anna Magdalena Guzik-Kornacka, Flуra Vajda, Martin E. Schwab
Chapter 21 - Intrinsic neuronal mechanisms in axon regeneration after spinal cord injury - Fengfeng Bei and Zhigang He
Chapter 22 - Voltage-gated ion channels as molecula
r targets for pain - Gerald W. Zamponi, Chongyang Hanand Stephen G. Waxman
Section 4: Activity-Dependent Plasticity and Neurorehabilitation
Chapter 24 - Neural Prostheses for Neurotrauma - Arthur Prochazka
Chapter 25 - Why is Fu
nctional Electrical Stimulation Therapy Capable of Restoring Motor Function Following Severe Injury to the Central Nervous System? - Mary K. Nagai, Cesar Marquez-Chin and Milos R. Popovic
Chapter 26 - Deep Brain Stimulation for Neuropsychiatric Disorders - Ausaf A. Bari, Nicolas Kon Kam King, Nir Lipsman and Andres M. Lozano
Chapter 27 - Novel Interventions for Stroke: Nervous System Cooling - Patrick D. Lyden, Jessica Lamb and Padmesh S. Rajput
Chap
Автор: Argyropoulos Georgios P. D. Название: Translational Neuroscience of Speech and Language Disorders ISBN: 3030356868 ISBN-13(EAN): 9783030356866 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides the first presentation of the state-of-the-art in the application of modern Neuroscience research in predicting, preventing and alleviating the negative sequelae of neurodevelopmental, acquired, or neurodegenerative brain abnormalities on speech and language.
A critical examination of translational medicine, when private risk is transferred to the public sector and university research teams become tech startups for global investors.
A global shift has secretly transformed science and medicine. Starting in 2003, biomedical research in the West has been reshaped by the emergence of translational science and medicine--the idea that the aim of research is to translate findings as quickly as possible into medical products. In The Market in Mind, Mark Dennis Robinson charts this shift, arguing that the new research paradigm has turned university research teams into small biotechnology startups and their industry partners into early-stage investment firms. There is also a larger, surprising consequence from this shift: according to Robinson, translational science and medicine enable biopharmaceutical firms, as part of a broader financial strategy, to outsource the riskiest parts of research to nonprofit universities. Robinson examines the implications of this new configuration. What happens, for example, when universities absorb unknown levels of risk? Robinson argues that in the years since the global financial crisis translational science and medicine has brought about "the financialization of health."
Robinson explores such topics as shareholder anxiety and industry retreat from Alzheimer's and depression research; how laboratory research is understood as health innovation even when there is no product; the emergence of investor networking events as crucial for viewing science in a market context; and the place of patients in research decisions. Although translational medicine justifies itself by the goal of relieving patients' suffering, Robinson finds patients' voices largely marginalized in translational neuroscience.
Описание: This case series book offers a practical and accessible approach to psychiatry, addressing major clinical problems ranging from psychosis to aging effects, each of which is tackled as it arises in everyday settings.
Описание: This volume highlights proteomics studies of quantitative PTM changes in both peripheral and central nervous system proteomes utilizing the most recent advances in mass spectrometry. Chapters include practical information pertaining to the fundamentals of sample preparation, liquid chromatography, and tandem mass spectrometry instrumental analysis and will elucidate best practices in the interpretation of data using modern bioinformatics approaches. Written for the popular Neuromethods series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.Authoritative and practical, Analysis of Post-Translational Modifications and Proteolysis in Neuroscience aims to ensure successful results in the further study of this vital field.
Автор: Conn, P. Michael Название: Conn`s Translational Neuroscience ISBN: 0128023813 ISBN-13(EAN): 9780128023815 Издательство: Elsevier Science Рейтинг: Цена: 20212.00 р. Наличие на складе: Нет в наличии.
Описание:
Conn's Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain, ' with the results providing insight into the underlying basis of many neurological disease processes.
This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis.
In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn's Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance.
Автор: Ghiso Jorge A, Rostagno Agueda A Название: Protein Folding Disorders Of The Central Nervous System ISBN: 9813222956 ISBN-13(EAN): 9789813222953 Издательство: World Scientific Publishing Рейтинг: Цена: 22018.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This exciting new book explores the dark side of the molecular protein assembly bringing an updated view of how failures in the homeostatic mechanisms that efficiently regulate protein folding leads to the accumulation of structurally abnormal pathogenic assemblies, encompassing an emerging group of diseases collectively known as "Protein Folding Disorders." This complex and diverse group of chronic and progressive entities are bridged together by their relationship to structural transitions in the native state of specific proteinaceous components, which for reasons poorly understood, convert into polymeric aggregates that generate poorly soluble tissue deposits and which are considered today the culprit of the disease pathogenesis in their respective diseases. Despite the diversity in the amino acid sequence of the different proteins involved in these heterogeneous disorders, all the pathologic conformers can trigger cascades of events ultimately resulting in cell dysfunction and death with devastating clinical consequences in many of the most precious aspects of human existence including personality, cognition, memory, and skilled movements.
This book, which is composed of a compilation of chapters authored by outstanding and well-published scientists in the respective fields currently performing active investigations at world renowned universities and research centers, focuses on the growing number of diseases associated with protein misfolding in the central nervous system. Individual chapters are dedicated to the most common neurodegenerative diseases associated with protein aggregation/fibrillization focusing on the nature of the pathogenic species and the cellular pathways involved in the molecular pathogenesis of Alzheimer's, Parkinson's, and Huntington's diseases as well as in Amyotrophic Lateral Sclerosis, and Prion disorders. A group of contributions is centered on the current knowledge of the intracellular pathways and subcellular organelles affected by the different disease conditions, while others are focused in the emerging pathogenic role of misfolded subunits assembled into neurotoxic soluble oligomers, and in the novel notion of the transmissibility of the protein misfolded species, an innovative concept until recently only accepted for Prion diseases. Lastly, a different set of chapters is dedicated to the evaluation of novel therapeutic strategies for these devastating diseases.
In Tracing Autism, Des Fitzgerald offers an up-close account of the search for a neurological explanation of autism. As autism has gained cultural prominence with more diagnoses and more controversy, its biological causes remain elusive.
Through in-depth interviews with neuroscientists, psychologists, and psychiatrists, Fitzgerald examines what it means to do scientific research in the ambiguous terrain of autism research, a field marked by shifting horizons of uncertainty and ambivalence. He draws out how autism scientists talk and feel their way through their research, demonstrating its profoundly affective character, and expanding our understanding of what is at stake in the new brain sciences.
Автор: Sanjeev Kumar Gupta, Srinivasan Venkatesan, S.P. Goswami, Rajeev Kumar Название: Emerging Trends in the Diagnosis and Intervention of Neurodevelopmental Disorders ISBN: 1522570047 ISBN-13(EAN): 9781522570042 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 33231.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Neurodevelopmental disorders encompass a group of conditions that can typically manifest during early childhood. These include intellectual disabilities, communication disorders, autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), specific learning disorder (SLD), and motor disorders. Early identification and assessment can be a valuable tool in determining diagnosis, prognosis, functional abilities, and formulating clinical intervention for both children and adults with neurodevelopmental disorders.Emerging Trends in the Diagnosis and Intervention of Neurodevelopmental Disorders is an essential reference source that discusses and disseminates contributions covering recent trends in diagnosis, assessment, and intervention techniques. Featuring research on topics such as clinical linguistics, neural connectivity, and animal-assisted therapy, this book is ideally designed for speech pathologists, social workers, occupational therapists, psychologists, psychiatrists, neurologists, pediatricians, researchers, clinicians, and academicians seeking coverage on neural and developmental disorder identification and strategies for clinician support and therapies.
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