This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.
This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Автор: T. Brown Название: Genomes 4 ISBN: 0815345089 ISBN-13(EAN): 9780815345084 Издательство: Taylor&Francis Рейтинг: Цена: 9645.00 р. Наличие на складе: Поставка под заказ.
Описание:
Genomes 4 has been completely revised and updated. It is a thoroughly modern textbook about genomes and how they are investigated. As with Genomes 3, techniques come first, then genome anatomies, followed by genome function, and finally genome evolution. The genomes of all types of organism are covered: viruses, bacteria, fungi, plants, and animals including humans and other hominids.
Genome sequencing and assembly methods have been thoroughly revised including a survey of four genome projects: human, Neanderthal, giant panda, and barley. Coverage of genome annotation emphasizes genome-wide RNA mapping, with CRISPR-Cas 9 and GWAS methods of determining gene function covered. The knowledge gained from these techniques forms the basis of the three chapters that describe the three main types of genomes: eukaryotic, prokaryotic (including eukaryotic organelles), and viral (including mobile genetic elements). Coverage of genome expression and replication is truly genomic, concentrating on the genome-wide implications of DNA packaging, epigenome modifications, DNA-binding proteins, non-coding RNAs, regulatory genome sequences, and protein-protein interactions. Also included are applications of transcriptome analysis, metabolomics, and systems biology. The final chapter is on genome evolution, focusing on the evolution of the epigenome, using genomics to study human evolution, and using population genomics to advance plant breeding. Established methods of molecular biology are included if they are still relevant today and there is always an explanation as to why the method is still important.
Each chapter has a set of short-answer questions, in-depth problems, and annotated further reading. There is also an extensive glossary. Genomes 4 is the ideal text for upper level courses focused on genomes and genomics.
Автор: Branton Daniel, Deamer David Название: Nanopore Sequencing: An Introduction ISBN: 9813270608 ISBN-13(EAN): 9789813270602 Издательство: Marston Book Services Рейтинг: Цена: от 4792.00 р. Наличие на складе: Есть
Описание:
This is an introductory text and laboratory manual to be used primarily in undergraduate courses. It is also useful for graduate students and research scientists who require an introduction to the theory and methods of nanopore sequencing. The book has clear explanations of the principles of this emerging technology, together with instructional material written by experts that describes how to use a MinION nanopore instrument for sequencing in research or the classroom.
At Harvard University the book serves as a textbook and lab manual for a university laboratory course designed to intensify the intellectual experience of incoming undergraduates while exploring biology as a field of concentration. Nanopore sequencing is an ideal topic as a path to encourage students about the range of courses they will take in Biology by pre-emptively addressing the complaint about having to take a course in Physics or Maths while majoring in Biology. The book addresses this complaint by concretely demonstrating the range of topics -- from electricity to biochemistry, protein structure, molecular engineering, and informatics -- that a student will have to master in subsequent courses if he or she is to become a scientist who truly understands what his or her biology instrument is measuring when investigating biological phenomena.
Автор: Strachan Название: Human Molecular Genetics ISBN: 0815345895 ISBN-13(EAN): 9780815345893 Издательство: Taylor&Francis Рейтинг: Цена: 12095.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Human Molecular Genetics has been carefully crafted over successive editions to provide an authoritative introduction to the molecular aspects of human genetics, genomics and cell biology.
Maintaining the features that have made previous editions so popular, this fifth edition has been completely updated in line with the latest developments in the field. Older technologies such as cloning and hybridization have been merged and summarized, coverage of newer DNA sequencing technologies has been expanded, and powerful new gene editing and single-cell genomics technologies have been added. The coverage of GWAS, functional genomics, stem cells, and disease modeling has been expanded. Greater focus is given to inheritance and variation in the context of populations and on the role of epigenetics in gene regulation.
Key features:
Fully integrated approach to the molecular aspects of human genetics, genomics, and cell biology
Accessible text is supported and enhanced throughout by superb artwork illustrating the key concepts and mechanisms
Summary boxes at the end of each chapter provide clear learning points
Annotated further reading helps readers navigate the wealth of additional information in this complex subject and provides direction for further study
Reorganized into five sections for improved access to related topics
Also new to this edition - brand new chapter on evolution and anthropology from the authors of the highly acclaimed Human Evolutionary Genetics
A proven and popular textbook for upper-level undergraduates and graduate students, the new edition of Human Molecular Genetics remains the 'go-to' book for those studying human molecular genetics or genomics courses around the world.
Автор: Cutter, Asher D. (professor, Professor, Department Of Ecology & Evolutionary Biology, University Of Toronto, Canada) Название: Primer of molecular population genetics ISBN: 0198838948 ISBN-13(EAN): 9780198838944 Издательство: Oxford Academ Рейтинг: Цена: 15840.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Provides a concise, accessible introduction to the principle ideas, methods, and caveats for understanding evolution at the molecular level.
Автор: Cutter Asher D Название: Primer of Molecular Population Genetics ISBN: 0198838956 ISBN-13(EAN): 9780198838951 Издательство: Oxford Academ Рейтинг: Цена: 8237.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Provides a concise, accessible introduction to the principal ideas, methods, and caveats for understanding evolution at the molecular level.
Автор: David J. Balding, Ida Moltke, John Marioni Название: Handbook of Statistical Genomics ISBN: 1119429145 ISBN-13(EAN): 9781119429142 Издательство: Wiley Рейтинг: Цена: 46086.00 р. Наличие на складе: Поставка под заказ.
Описание: Previous title: Handbook of statistical genetics.
Автор: Michael Hehenberger, Zhi Xia Название: Our Animal Connection: What Sapiens Can Learn From Other Species ISBN: 9814800481 ISBN-13(EAN): 9789814800488 Издательство: Taylor&Francis Рейтинг: Цена: 9492.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book covers the many ways humans benefit from interactions with other living species. By studying animals of all kinds and sizes, from microbial organisms to elephants and whales, we can learn about their adaptations to extreme conditions on planet Earth, about the evolutionary development of specialized capabilities, and about their ways to defend themselves against predators and diseases. We discuss the strengths and weaknesses of Homo Sapiens, and how the study of animals can make us stronger and healthier. To increase our knowledge of genetics, molecular and cell biology, physiology and medicine, we need to study model organisms. To cure human disease, we can learn from animals how they have evolved ways to protect themselves. To improve our human performance, we can study the animal kingdom’s top performers and possibly learn from their successes. Finally, we review genetic engineering techniques that can translate our existing and future animal connections into benefits for human health and performance.
Описание: The increased and widespread availability of large network data resources in recent years has resulted in the increased need for effective methods for the analysis of these networks. The challenge is to detect patterns that provide a better understanding of the data. However, this is not a straight forward task because of the size of the data sets and the computer power required for the analyses. The solution is to devise methods for approximately answering the questions posed, and these methods will vary depending on the data sets under scrutiny. This cutting-edge text introduces graph and network theory, cluster analysis and machine learning, before discussing the thought processes and creativity involved in the analysis of large-scale biological and medical data sets, using a wide range of real-life examples. Bringing together leading experts, this inter-disciplinary text provides an ideal introduction to and insight into the field of network data analysis.
Автор: Bahar Taneri, Esra Asilmaz, T?rem Delikurt, Pembe Название: Human Genetics and Genomics: A Practical Guide ISBN: 3527337482 ISBN-13(EAN): 9783527337484 Издательство: Wiley Рейтинг: Цена: 8395.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Finally meeting the need for a laboratory manual on human genetics, this practical guide is the perfect companion title to all major standard textbooks on the subject. The authors all have a high-level research background and are actively involved in teaching and counseling. Based on a standard curriculum in human genetics, each chapter equals one practical unit of the course and topics range from basics in human inheritance to genetics in major disease clusters and from bioinformatics and personalized medicine to genetic counseling.
Автор: Fink, George Название: Stress Genetics, Epigenetics And Genomics ISBN: 012813156X ISBN-13(EAN): 9780128131565 Издательство: Elsevier Science Рейтинг: Цена: 19875.00 р. Наличие на складе: Поставка под заказ.
Описание:
The effect of stress on our emotional and physical health can be devastating. There have been significant advances in our understanding of stress genetics and genomics, and the field of epigenetics has flourished during this time, yet many remain unfamiliar with the latest concepts on these topics. This intense public, research, and clinical interest in stress is reflected in our edited Handbook of Stress series, each volume addressing a specific area within the field of stress edited by experts in each subfield. Stress Genetics, Epigenetics, and Genomics, Volume 4 in the series, covers the influence genetics, epigenetics, and genomics have on physiologic stress and provides a quick orientation to the subject for research, clinic, and everyday life. Integrated closely with new behavioral findings and relevance to human conditions, the concepts and data in this volume offer readers cutting-edge information on the genetics of stress. This volume is of prime interest to neuroscientists, clinicians, researchers, academics, and students in Neuroendocrinology, Neuroscience, Biomedicine, Endocrinology, Psychology, Psychiatry and some aspects of the Social Sciences including stress and its management in the workplace from a preventative, diagnostic, and therapeutic perspective.
Автор: Daniel L. Hartl; Andrew G. Clark Название: Principles of Population Genetics ISBN: 0878933085 ISBN-13(EAN): 9780878933082 Издательство: Springer Рейтинг: Цена: 15689.00 р. Наличие на складе: Поставка под заказ.
Описание: David Lindsay was a writer of fantasy fiction who died in 1945. Interest in Lindsay has been growing steadily, and in this book, Bernard Sellin has written a comprehensive survey of Lindsay`s life and work, analysing the thematic patterns of Lindsay`s settings, plots and characters. It will be read with profit by all those who are interested both in Lindsay and in the genre of fantasy literature.
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