Описание: Oligonucleotides represent one of the most significant pharmaceutical breakthroughs in recent years, showing great promise as diagnostic and therapeutic agents for malignant tumors, cardiovascular disease, diabetes, viral infections, and many other degenerative disorders. The Handbook of Analysis of Oligonucleotides and Related Products is an essential reference manual on the practical application of modern and emerging analytical techniques for the analysis of this unique class of compounds. A strong collaboration among thirty leading analytical scientists from around the world, the book provides readers with a comprehensive overview of the most commonly used analytical techniques and their advantages and limitations in assuring the identity, purity, quality, and strength of an oligonucleotide intended for therapeutic use. Topics discussed include: Strategies for enzymatic or chemical degradation of chemically modified oligonucleotides toward mass spectrometric sequencing Purity analysis by chromatographic or electrophoretic methods, including RP-HPLC, AX-HPLC, HILIC, SEC, and CGE Characterization of sequence-related impurities in oligonucleotides by mass spectrometry and chromatography Structure elucidation by spectroscopic methods (IR, NMR, MS) as well as base composition and thermal melt analysis (Tm) Approaches for the accurate determination of molar extinction coefficient of oligonucleotides Accurate determination of assay values Assessment of the overall quality of oligonucleotides, including microbial analysis and determination of residual solvents and heavy metals Strategies for determining the chemical stability of oligonucleotides The use of hybridization techniques for supporting pharmacokinetics and drug metabolism studies in preclinical and clinical development Guidance for the presentation of relevant analytical information towards meeting current regulatory expectations for oligonucleotide therapeutics This resource provides a practical guide for applying state-of-the-art analytical techniques in research, development, and manufacturing settings.
Автор: Ajar Nath Yadav, Shashank Mishra Название: Recent Advancement in White Biotechnology Through Fungi: Volume 2: Perspective for Value-Added Products and Environments ISBN: 3030148459 ISBN-13(EAN): 9783030148454 Издательство: Springer Рейтинг: Цена: 9782.00 р. 13974.00-30% Наличие на складе: Есть (1 шт.) Описание: White biotechnology is industrial biotechnology dealing with various biotech products through applications of microbes. The main application of white biotechnology is commercial production of various useful organic substances, such as acetic acid, citric acid, acetone, glycerine, etc., and antibiotics like penicillin, streptomycin, mitomycin, etc., and value added product through the use of microorganisms especially fungi and bacteria. The value-added products included bioactive compounds, secondary metabolites, pigments and industrially important enzymes for potential applications in agriculture, pharmaceuticals, medicine and allied sectors for human welfare. In the 21st century, techniques were developed to harness fungi to protect human health (through antibiotics, antimicrobial, immunosuppressive agents, value-added products etc.), which led to industrial scale production of enzymes, alkaloids, detergents, acids, biosurfactants. The first large-scale industrial applications of modern biotechnology have been made in the areas of food and animal feed production (agricultural/green biotechnology) and pharmaceuticals (medical/red biotechnology). In contrast, the production of bio-active compounds through fermentation or enzymatic conversion is known industrial or white biotechnology. The beneficial fungal strains may play important role in agriculture, industry and the medical sectors. The beneficial fungi play a significance role in plant growth promotion, and soil fertility using both, direct (solubilization of phosphorus, potassium and zinc; production of indole acetic acid, gibberellic acid, cytokinin and siderophores) and indirect (production of hydrolytic enzymes, siderophores, ammonia, hydrogen cyanides and antibiotics) mechanisms of plant growth promotion for sustainable agriculture. The fungal strains and their products (enzymes, bio-active compounds and secondary metabolites) are very useful for industry. The discovery of antibiotics is a milestone in the development of white biotechnology. Since then, white biotechnology has steadily developed and now plays a key role in several industrial sectors, providing both high valued nutraceuticals and pharmaceutical products. The fungal strains and bio-active compounds also play important role in the environmental cleaning. This volume covers the latest research developments related to value-added products in white biotechnology through fungi.
Автор: Ronald R. Pethig Название: Dielectrophoresis: Theory, Methodology and Biologi cal Applications ISBN: 1118671457 ISBN-13(EAN): 9781118671450 Издательство: Wiley Рейтинг: Цена: 13300.00 р. 19000.00-30% Наличие на складе: Есть (1 шт.) Описание: Comprehensive coverage of the basic theoretical concepts and applications of dielectrophoresis from a world-renowned expert.
Автор: Ignacimuthu Название: Biotechnology ISBN: 1842657542 ISBN-13(EAN): 9781842657546 Издательство: Alpha Science Рейтинг: Цена: 6000.00 р. 8571.00-30% Наличие на складе: Есть (1 шт.) Описание: Biotechnology: An Introduction resurfaces as a new edition, with all the relevant information on fundamental aspects and areas of biotechnology. Covering topics of Genetic Engineering, Plant Tissue Culture, Plant Biotechnology, Healthcare Biotechnology, Environmental Biotechnology, Bacterial Genetics, Animal Tissue Culture, Animal Biotechnology, Industrial Biotechnology and Ethics - all of which are comprised in a simple and lucid manner inclusive of all readers.
Автор: Yadav Mukesh, Kumar Vikas, Sehrawat Nirmala Название: Industrial Biotechnology: Plant Systems, Resources and Products ISBN: 3110563304 ISBN-13(EAN): 9783110563306 Издательство: Walter de Gruyter Цена: 11334.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Industrial Biotechnology summarizes different aspects of plant biotechnology such as using plants as sustainable resources, phytomedical applications, phytoremedation and genetic engineering of plant systems. These topics are discussed from an academic as well industrial perspective and thus highlight recent developments but also practical aspects of modern biotechnology.
Автор: Khoobchandani Menka, Saxena Arpita Название: Biotechnology Products in Everyday Life ISBN: 3319923986 ISBN-13(EAN): 9783319923987 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book explores a sampling of the most powerful and enterprising efforts to achieve biotechnological goals by means of various interdisciplinary approaches. From the fabrication of extremely small units to achieve specific objectives through nano-bio-technology, to devices with artificial intelligence, gene therapy for cerebrovascular anomalies, biodegradable plastics, the use of phyto-stem cells in cosmetology, CarT cell immune therapy, targeted therapies for cancer, 3D printed bones developed by the University of Wollongong in Australia, the sickle cell chip developed by IIT Bombay, and innovative sustainable energy solutions, the book includes a colorful spectrum of reviews on current and future biotech products. Gathering contributions by an international team of researchers, this book offers its audience, and particularly younger readers, revealing information on current and upcoming smart technologies.
Автор: Lundblad Название: Biotechnology of Plasma Proteins ISBN: 1439850267 ISBN-13(EAN): 9781439850268 Издательство: Taylor&Francis Рейтинг: Цена: 29093.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
The fractionation of human blood plasma can be considered to be a mature industry, with the basic technology, alcohol fractionation, dating back at least to the 1940s. Many of the products described in the current work have been approved biologics since the 1950s. The information gathered from the development of plasma proteins has proved vital to the development of recombinant therapeutic proteins.
Discussing the role of plasma proteins in current biotechnology, Biotechnology of Plasma Proteins describes the protein composition of human plasma, the fractionation of plasma to obtain therapeutic proteins, and the analysis of these products. It delineates the path from plasma products to recombinant products, and highlights products from albumin, intravenous immunoglobins, and coagulation. It offers a comprehensive review of current techniques for the analysis of proteins including electrophoresis, chromatography, spectrophotometry, mass spectrometry, and updates not published since 1975.
Key Topics
Protein Composition of Plasma
Proteomic methods for plasma protein analysis
Plasma protein biomarkers
Validation of biomarkers
Assays for plasma biomarkers
Methods for the Analysis of Protein Products
Assay development and validation
Electrophoresis
Chromatography
Immunoassay
Mass spectrometry
Raman spectroscopy
Plasma Fractionation: Historical and Modern Methods
Development of Cohn alcohol fractionation
Industrial methods
Development of chromatographic methods
Plasma Protein Products of Therapeutic Value
Albumin
Intravenous immunoglobulin
Coagulation products
Growth factors
Wound management
Автор: Hu Название: Engineering Fundamentals of Biotechnology ISBN: 1119159024 ISBN-13(EAN): 9781119159025 Издательство: Wiley Рейтинг: Цена: 14723.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is a short introduction to the engineering principles of harnessing the vast potential of microorganisms, and animal and plant cells in making biochemical products. It was written for scientists who have no background in engineering, and for engineers with minimal background in biology. The overall subject dealt with is process.
Автор: Micou Название: A Laboratory Course in Tissue Engineering ISBN: 1439878935 ISBN-13(EAN): 9781439878934 Издательство: Taylor&Francis Рейтинг: Цена: 11176.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Filling the need for a lab textbook in this rapidly growing field, A Laboratory Course in Tissue Engineering helps students develop hands-on experience. The book contains fifteen standalone experiments based on both classic tissue-engineering approaches and recent advances in the field. Experiments encompass a set of widely applicable techniques: cell culture, microscopy, histology, immunohistochemistry, mechanical testing, soft lithography, and common biochemical assays. In addition to teaching these specific techniques, the experiments emphasize engineering analysis, mathematical modeling, and statistical experimental design.
A Solid Foundation in Tissue Engineering--and Communication Skills
Each experiment includes background information, learning objectives, an overview, safety notes, a list of materials, recipes, methods, pre- and postlab questions, and references. Emphasizing the importance for engineering students to develop strong communication skills, each experiment also contains a data analysis and reporting section that supplies a framework for succinctly documenting key results. A separate chapter provides guidelines for reporting results in the form of a technical report, journal article, extended abstract, abstract, or technical poster.
Customize Your Courses with More Than a Semester's Worth of Experiments
The book is a convenient source of instructional material appropriate for undergraduate or graduate students with fundamental knowledge of engineering and cell biology. All of the experiments have been extensively tested to improve the likelihood of successful data collection. In addition, to minimize lab costs, the experiments make extensive use of equipment commonly found in laboratories equipped for tissue culture. A solutions manual, available with qualifying course adoption, includes answers to pre- and postlab questions, suggested equipment suppliers and product numbers, and other resources to help plan a new tissue engineering course.
Автор: Vijai Kumar Gupta Название: Biotechnology of Fungal Genes ISBN: 1578087872 ISBN-13(EAN): 9781578087877 Издательство: Taylor&Francis Рейтинг: Цена: 29093.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume focuses on filamentous fungi and highlights the advances of the past decade, both in methodology and in the understanding of genomic organization and regulation of gene and pathway expression.
Описание: "Microalgae Biotechnology for Food, Health and High Value Products" presents the latest technological innovations in microalgae production, market status of algal biomass-based products, and future prospects for microalgal applications.
Автор: Kuete Victor Название: Biodiversity, Natural Products and Cancer Treatment ISBN: 9814583502 ISBN-13(EAN): 9789814583503 Издательство: World Scientific Publishing Рейтинг: Цена: 20592.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This book is the first of its kind in bringing together biodiversity, chemical ecology, phytochemistry and cancer therapy. The highlight of the book is an exhaustive compilation of scientific data on biodiversity of medicinal plants, biodiversity and metagenomics, chemical ecology of medicinal plants, chemical ecology of marine organisms, natural products from terrestrial microbial organisms with activity towards cancer cells, marine organisms, ethnopharmacology and phytotherapy, contribution of African flora in world fight against cancer, natural products derived from terrestrial plants with activity towards cancer cells and established anticancer drugs from natural origin.
The book discusses the state-of-the-art of each topic to serve as reference resource tools for graduate students as well as scientists and scholars in pharmaceutical sciences, pharmacology, organic chemistry and biochemistry, pharmacognosy, phytochemistry, ethnomedicine and ethnopharmacology, complementary and alternative medicine, medical and public health sciences and others. It includes cutting-edge developments in anticancer discovery from both medicinal plants and organisms.
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