Precision Oncology and Cancer Biomarkers: Issues at Stake and Matters of Concern, Bremer Anne, Strand Roger

Автор: Magdalena Thurin; Alessandra Cesano; Francesco M.
Название: Biomarkers for Immunotherapy of Cancer
ISBN: 1493997726 ISBN-13(EAN): 9781493997725
Издательство: Springer
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Цена: 21661.00 р.
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Описание: This book provides the immune oncology (IO) community with a deeper understanding of the scope of the biomarker methods to potentially improve the outcome from immunotherapy. The editors secured the input from experts in the field dedicated to translating scientific research from bench to bedside was submitted. The book provides not only details about the technical, standardization and interpretation aspects of the methods but also introduces the reader to the background information and scientific justification for selected biomarkers and assays. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Автор: Gabriel D. Dakubo
Название: Cancer Biomarkers in Body Fluids
ISBN: 3319483595 ISBN-13(EAN): 9783319483597
Издательство: Springer
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Цена: 32142.00 р.
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Описание: This book examines in depth the evidence, clinical applications and potential cancer signatures in the circulation and discusses alterations in circulating cell-free nucleic acids, and circulating tumor DNA, as well as the epigenome, genome, transcriptome (coding and noncoding), proteome (both traditional serum proteins and proteomic profiles) and metabolome. Further, it highlights the clinical applications of circulating tumor cells for each cancer type and addresses the emerging importance of extracellular vesicular contents, including miRNA, oncogenes and drug resistant factors. As such, it offers a valuable reference guide for cancer researchers, oncologists, clinicians, surgeons, medical students, oncology nurses, diagnostic laboratories, and the pharmaceutical industry.

Автор: Dakubo
Название: Cancer Biomarkers in Body Fluids
ISBN: 3319015796 ISBN-13(EAN): 9783319015798
Издательство: Springer
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Цена: 25155.00 р.
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Описание: The molecular and genetic signatures of cancer are represented in the peripheral circulation and other body fluids, giving rise to the “liquid biopsy” concept. This new paradigm of molecular profiling of cancer cells offers several advantages over traditional tissue biopsy. It is convenient, noninvasive, conforms to current clinical practice, enables real time disease monitoring and the study of tumor evolution, can easily be sampled multiple times, and this sample is more representative of the heterogeneous cancer cells than biopsy sampling. Indeed, all aspects of cancer molecular genetic information, stemming from DNA (both nuclear and mitochondria), RNA (coding and noncoding), peptides and proteins, metabolites and lipids are present in body fluids as free, cell surface bound or enclosed in membrane vesicles, and are being harnessed for disease management. Additionally, circulating tumor, and tumor stem cells provide prognostic information, and also enable the study of the intricate molecular processes associated with metastasis and drug resistance. This treatise deals with the general principles of the molecular pathology of cancer, and its associated imprints in circulation. The transitional process from discovery, prototype development, translational research, to product development can be complex and costly. The critical path to biomarker development and qualification for successful use in drug development is detailed herein as well.This book is of interest to Cancer Researchers, Oncologists, Clinicians, Surgeons, Medical Students, Nurses, Diagnostic Laboratories, and Pharmaceutical Industries.??

Автор: Harndan
Название: Cancer Biomarkers. 2007
ISBN: 0471745162 ISBN-13(EAN): 9780471745167
Издательство: Wiley
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Цена: 21376.00 р.
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Описание: Tools, techniques, and progress in cancer biomarkers discovery The completion of a number of gene sequencing projects, recent advances in genomic and proteomic technologies, and the availability of powerful bioinformatics tools have led to promising new avenues and approaches in the search for cancer biomarkers.

Автор: Edelstein, Charles L.
Название: Biomarkers of Kidney Disease
ISBN: 0128030143 ISBN-13(EAN): 9780128030141
Издательство: Elsevier Science
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Цена: 14654.00 р.
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Описание:

Biomarkers of Kidney Disease, Second Edition, focuses on the basic and clinical research of biomarkers in common kidney diseases, detailing the characteristics of an ideal biomarker. The latest techniques for biomarker detection, including metabolomics and proteomics are covered in the book.

Автор: Lenz H. G.
Название: Biomarkers in Oncology
ISBN: 1441997547 ISBN-13(EAN): 9781441997548
Издательство: Springer
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Цена: 25155.00 р.
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Описание: This integrated book covers the entire spectrum of cancer biomarkers in development and clinical use. Predictive and prognostic markers are explored in the context of colon cancer, breast cancer, lung cancer, prostate cancer, and GIST. International experts provide insight into toxicity markers and surrogate markers. Attention is also given to biomarker assay development, validation, and strategies. A powerful tool for determining decisions on therapy, selecting drug regimens, monitoring the efficacy of treatment, and performing individualized surveillance, biomarkers represent the forefront of cancer research and treatment. As these technologies become increasingly available for clinical use, this book will be an essential resource for oncologists and translational researchers.

Название: Handbook of Therapeutic Biomarkers in Cancer
ISBN: 9814364657 ISBN-13(EAN): 9789814364652
Издательство: Taylor&Francis
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Цена: 21437.00 р.
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Описание: In this volume, a team of internationally recognized experts provide an in-depth description of therapeutic biomarkers across a broad area of cancer research and oncology. With a wealth of information to specific therapies, each chapter focuses on a class of targeted chemotherapy agents. The book describes established and evolving diagnostic tests for therapeutic biomarkers that predict benefit, response, resistance, or drug side effects from specific therapeutic interventions. This volume is an essential handbook for health professionals and scientists researching current applicable biomarkers in oncology.

Автор: Lenz
Название: Biomarkers in Oncology
ISBN: 1461483158 ISBN-13(EAN): 9781461483151
Издательство: Springer
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Цена: 16769.00 р.
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Описание: This integrated book covers the entire spectrum of cancer biomarkers in development and clinical use. Predictive and prognostic markers are explored in the context of colon cancer, breast cancer, lung cancer, prostate cancer, and GIST.

Автор: Shimada
Название: Biomarkers in Cancer Therapy
ISBN: 9811372942 ISBN-13(EAN): 9789811372940
Издательство: Springer
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Цена: 12577.00 р.
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Автор: El Bairi Khalid
Название: Ovarian Cancer Biomarkers: Mapping to Improve Outcomes
ISBN: 9811618720 ISBN-13(EAN): 9789811618727
Издательство: Springer
Цена: 15372.00 р.
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Описание: This book comprehensively summarizes the biology, etiology, and pathology of ovarian cancer and explores the role of deep molecular and cellular profiling in the advancement of precision medicine. In turn, the book highlights the development of resistance, disease occurrence, and poor prognosis that are the hallmarks of ovarian cancer.

Автор: Victor R. Preedy; Vinood B. Patel
Название: Biomarkers in Cancer
ISBN: 9400776802 ISBN-13(EAN): 9789400776807
Издательство: Springer
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Цена: 48913.00 р.
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Описание: The World Health Organisation have reported that each year on a global basis there are over 8 million deaths from cancer. This is 13% of all deaths. As well as those who die, there are many who are being treated for cancer. Some cancers, hitherto deemed to be incurable, can now be cured. Part of the overall package of healthcare related to cancer is the application of biomarkers. Biomarkers can be used not only to determine stages and effects of cancer, but also to aid treatments regimes. Biomarkers in Cancer combines detailed information on cancer types and the use of biological indicators. It covers the latest knowledge, trends and applications. It links conventional approaches with new platforms

Автор: Dakubo Gabriel D.
Название: Cancer Biomarkers in Body Fluids: Principles
ISBN: 331979129X ISBN-13(EAN): 9783319791296
Издательство: Springer
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Цена: 20962.00 р.
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Описание: The molecular and genetic signatures of cancer are represented in the peripheral circulation and other body fluids, giving rise to the “liquid biopsy” concept. This new paradigm of molecular profiling of cancer cells offers several advantages over traditional tissue biopsy. It is convenient, noninvasive, conforms to current clinical practice, enables real time disease monitoring and the study of tumor evolution, can easily be sampled multiple times, and this sample is more representative of the heterogeneous cancer cells than biopsy sampling. Indeed, all aspects of cancer molecular genetic information, stemming from DNA (both nuclear and mitochondria), RNA (coding and noncoding), peptides and proteins, metabolites and lipids are present in body fluids as free, cell surface bound or enclosed in membrane vesicles, and are being harnessed for disease management. Additionally, circulating tumor, and tumor stem cells provide prognostic information, and also enable the study of the intricate molecular processes associated with metastasis and drug resistance. This treatise deals with the general principles of the molecular pathology of cancer, and its associated imprints in circulation. The transitional process from discovery, prototype development, translational research, to product development can be complex and costly. The critical path to biomarker development and qualification for successful use in drug development is detailed herein as well. This book is of interest to Cancer Researchers, Oncologists, Clinicians, Surgeons, Medical Students, Nurses, Diagnostic Laboratories, and Pharmaceutical Industries.