Описание: This volume presents a unique comparative treatment of the role oxidative stress plays in vertebrates and invertebrates in multiple organ systems with regards to cell death, development, aging, and human diseases, and anti-oxidant therapy.
Автор: Huang Canhua, Zhang Yuanyuan Название: Oxidative Stress: Human Diseases and Medicine ISBN: 9811605211 ISBN-13(EAN): 9789811605215 Издательство: Springer Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this book, the authors attempt to re-define the key concepts in oxidative stress, such as oxidative eustress and oxidative distress, revisit the pivotal signaling of oxidative stress in human diseases, and discuss the debate in current anti-oxidant strategies, such as natural products and drug repurposing.
Автор: Amandeep Kaur Название: Fluorescent Tools for Imaging Oxidative Stress in Biology ISBN: 3030103714 ISBN-13(EAN): 9783030103712 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This thesis advances the long-standing challenge of measuring oxidative stress and deciphering its underlying mechanisms, and also outlines the advantages and limitations of existing design strategies. It presents a range of approaches for the chemical synthesis of fluorescent probes that detect reversible changes in cellular oxidative stress. The ability to visualise cellular processes in real-time is crucial to understanding disease development and streamline treatment, and this can be achieved using fluorescent tools that can sense reversible disturbances in cellular environments during pathogenesis. The perturbations in cellular redox state are of particular current interest in medical research, since oxidative stress is implicated in the pathogenesis of a number of diseases.The book investigates different strategies used to achieve ratiometric fluorescence output of the reversible redox probes, which nullify concentration effects associated with intensity-based probes. It also describes suitable approaches to target these probes to specific cellular organelles, thereby enabling medical researchers to visualise sub-cellular oxidative stress levels, and addressing the typically poor uptake of chemical tools into biological studies. In total it reports on four new probes that are now being used by over twenty research groups around the globe, and two of which have been commercialised. The final chapters of this thesis demonstrate successful applications of the sensors in a variety of biological systems ranging from prokaryotes to mammalian cells and whole organisms. The results described clearly indicate the immense value of collaborative, cross-disciplinary research.
Название: Vitamin D Oxidative Stress, Immunit ISBN: 1138199443 ISBN-13(EAN): 9781138199446 Издательство: Taylor&Francis Рейтинг: Цена: 10411.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Vitamin D insufficiency/deficiency is a worldwide, public health problem in both developed and developing countries. Rickets among infants has reemerged. Low levels of vitamin D are associated with increased risk and mortality from cancer. At the same time, the beneficial effects of vitamin D on a host of conditions have recently been discovered. Focusing on areas not extensively covered in other comparable books, Vitamin D: Oxidative Stress, Immunity, and Aging highlights the most recent research findings on the impact of this nutrient in oxidative stress, immunity, and aging.
A state-of-the-art compilation of essential information, this book explores:
Vitamin D and its genomic and nongenomic effects, the role of therapeutic analogs in treating disease, and the production of vitamin D by the body
The role vitamin D plays in modulating oxidative stress--with emphasis on cancer, stress-mediated diseases, photo-protection of the skin, and energy metabolism
Beneficial effects of vitamin D in regulating the immune response and its importance in protecting against autoimmune, infectious, and inflammatory diseases
The role vitamin D plays in the regulation of the aging process--including aspects of oxidative stress, senescence, and mortality, as well as its role in protection against cardiovascular disease and nervous system disorders
This book represents an important contribution toward understanding the mechanisms by which vitamin D promotes health, increasing awareness of the importance that vitamin D plays during development, at birth, and throughout the aging process. It is a valuable reference for researchers in academia, nutrition, medicine, and industry.
Автор: Kaur Название: Fluorescent Tools for Imaging Oxidative Stress in Biology ISBN: 3319734040 ISBN-13(EAN): 9783319734040 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Introduction.- Flavin based redox probes.- FRET based ratiometric redox probes.- Mitochondrially-targeted ratiometric redox probes.- Nicotinamide based ratiometric probes.- In cellulo studies.- Ex vivo studies.- Non-mammalian systems.- Conclusions.- Experimental Methods.
Автор: Chakraborti Название: Oxidative Stress in Heart Diseases ISBN: 9811382727 ISBN-13(EAN): 9789811382727 Издательство: Springer Рейтинг: Цена: 34937.00 р. Наличие на складе: Поставка под заказ.
Описание: This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.
Автор: Maurya Pawan K., Dua Kamal Название: Role of Oxidative Stress in Pathophysiology of Diseases ISBN: 9811515670 ISBN-13(EAN): 9789811515675 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Chapter 1. Preface.- Chapter 2.Introduction.- Chapter 2.1. Oxidative stress and its biological significance.- Chapter 2.2. Free radicals and biological systems.- Chapter 2.3.Oxidative stress balance system.- Chapter 3. Role of oxidative stress in aging process.- Chapter 4. Oxidative stress in diseases.- Chapter 4.1. Oxidative stress in neurology and in neurodegenerative processes.- Chapter 4.2. Oxidative stress and Cardiology.- Chapter 4.3. Oxidative stress in chronic kidney disease.- Chapter 4.4.Oxidative Stress and Atherosclerosis.- Chapter 4.5. Oxidative stress and cancer.- Chapter 4.6. Oxidative stress in respiratory diseases.- Chapter 4.7. Oxidative stress and epigenetics.- Chapter 5. Oxidative stress monitoring using in vitro and in vivo models.- Chapter 6. Detection of oxidative stress biomarkers using biosensors.- Chapter 7. Pharmaceutical treatments and strategies for anti-oxidative stress.- Chapter 8. Effects of exercise training to the oxidative stress treatment.- Chapter 9. Advancements in novel drug delivery systems: Providing a challenge and threat to oxidative stress in various diseases.- Chapter 10. Future prospects and challenges.- Chapter 11. Bibliography.- Chapter 12. Glossary.
Автор: Mieczyslaw Pokorski Название: Oxidative Stress and Cardiorespiratory Function ISBN: 3319384899 ISBN-13(EAN): 9783319384894 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Cardiorespiratory function is prominently affected by oxidative stress. Alterations in inflammatory cytokines and proteins as well as degradation of muscle proteins due to smoking, by far unrecognized, caused by oxidative stress also are presented.
Автор: Huang Название: Oxidative Stress ISBN: 9811605246 ISBN-13(EAN): 9789811605246 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Поставка под заказ.
Описание: In this book, the authors attempt to re-define the key concepts in oxidative stress, such as oxidative eustress and oxidative distress, revisit the pivotal signaling of oxidative stress in human diseases, and discuss the debate in current anti-oxidant strategies, such as natural products and drug repurposing.
Автор: Sajal Chakraborti; Tapati Chakraborti; Dhrubajyoti Название: Oxidative Stress in Microbial Diseases ISBN: 9811387621 ISBN-13(EAN): 9789811387623 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This book discusses recent advances in our understanding of the role of oxidants in microbial pathophysiology, providing valuable insights into the complex role of reactive oxygen species (ROS) in host-microbial interactions. The various chapters take readers through the function of ROS in infections ranging from viral to bacterial, and describe how microorganisms have developed complex strategies to not only avoid contact with phagocyte-derived oxidants, but also protect themselves from injury when oxidants are encountered. Featuring the latest research in the field of microbial diseases, this timely book is a ready reference for scientists looking to develop new anti-microbial drugs.
Автор: Chakraborti Sajal, Chakraborti Tapati, Das Salil Kumar Название: Oxidative Stress in Lung Diseases: Volume 1 ISBN: 9811384126 ISBN-13(EAN): 9789811384127 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This first volume of the comprehensive, two-volume work on oxidative stress in lung disease introduces the molecular mechanisms, and the role of oxidants in the progression of different lung diseases. The lungs of humans and animals are under constant threat from oxidants from either endogenous (e.g. in situ metabolic reactions) or exogenous sources (e.g. air pollutants). Further, oxidative stress causes the oxidation of proteins, DNA and lipids, which in turn generates secondary metabolic products. The book consists of sections, each focusing on different aspects of oxidant-mediated lung diseases. As such it is a unique reference resource for postgraduate students, biomedical researchers and also for the clinicians who are interested in studying and understanding oxidant-mediated lung diseases. The second volume will incorporate other aspects of oxidant-mediated lung diseases, including prevention and therapeutics.
Автор: Sanjay K. Srivastava Название: Role of Capsaicin in Oxidative Stress and Cancer ISBN: 9401784299 ISBN-13(EAN): 9789401784290 Издательство: Springer Рейтинг: Цена: 16977.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress and much more.
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