Описание: Animal models and tests have become increasingly important for biomedical research, enabling a better understanding of pathogenic pathways involved in various human disorders. Over the last decades, zebrafish (Danio rerio) have become a very popular model organism in biomedical research. Recently, this fish has entered the waters of neuroscience and biological psychiatry, quickly becoming an indispensable model species in this field. With a high genetic homology to humans ( 75% based on coding regions), it is not surprising that humans and fish are very similar physiologically (and behaviorally). Therefore, it should not come as a surprise that zebrafish can be an excellent model of human neuropsychiatric disorders. While some classical psychiatrists may not too easily be persuaded by this generalization, the current book "The rights and wrongs of zebrafish: principles of behavioral phenotyping and CNS disease modeling" explains, in a domain-by-domain manner, how exactly zebrafish models can be used to target a wide range of human brain disorders and aberrant phenotypes. The contributors to this book are leading international scholars whose work spearheads innovative zebrafish neuroscience research around the world. Written by top experts in the field, this book makes for a useful, balanced and up-to-date reading that outlines the use of zebrafish to study the pathological mechanisms underlying neuropsychiatric disorders.
Автор: Cartner, Samual Название: Cartner-The Zebrafish in Biomedical Research ISBN: 0128124318 ISBN-13(EAN): 9780128124314 Издательство: Elsevier Science Рейтинг: Цена: 23075.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text provides significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using the species to gain critical insights into human physiology and disease. As the zebrafish has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery, this book presents an important resource for future research.
Presents a complete view of the zebrafish, covering their biology, husbandry, diseases and research applications
Includes the work of world-renowned authors
Provides the first authoritative and comprehensive treatment of zebrafish in biomedical research as part of the ACLAM series
Автор: Allan V. Kalueff; Adam Michael Stewart Название: Zebrafish Protocols for Neurobehavioral Research ISBN: 1493960024 ISBN-13(EAN): 9781493960026 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Zebrafish play an integral role in biomedical research, enabling scientists to examine physiological mechanisms and pathways relevant to human pathogenesis and its therapy. Written by experts, this volume sets out protocols for both larval and adult models.
Автор: Detrich, III, H. William Название: The Zebrafish: Genetics, Genomics, and Transcriptomics,135 ISBN: 0128034742 ISBN-13(EAN): 9780128034743 Издательство: Elsevier Science Рейтинг: Цена: 21222.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: "
The Zebrafish: Genetics, Genomics, and Transcriptomics, Fourth Edition, "is the latest volume in the "Methods in Cell Biology "series that looks at methods for the analysis of genetics, genomics, and transcriptomics of Zebrafish.
Chapters cover such topics as gene-trap mutagenesis, genetic Screens for mutations, gene editing in zebrafish, homologous gene targeting, genome-wide RNA tomography, and developmental epigenetics and the zebrafish interactome. Covers sections on model systems and functional studies, imaging-based approaches, and emerging studiesPresents chapters written by experts in the fieldContains cutting-edge material on the topic
Автор: Dr. Thomas Mueller Название: Atlas of Early Zebrafish Brain Development ISBN: 0124186696 ISBN-13(EAN): 9780124186699 Издательство: Elsevier Science Рейтинг: Цена: 15917.00 р. Наличие на складе: Поставка под заказ.
Описание: . Atlas of Early Zebrafish Brain Development: A Tool for Molecular Neurogenetics, Second Edition, remains the only neuroanatomical expression atlas of important genetic and immunohistochemical markers of this vertebrate model system. . It represents a key reference and interpretation matrix for analyzing expression domains of genes involved in Zebrafish brain development and neurogenesis, and serves as a continuing milestone in this research area. . This updated volume provides in-situ hybridized and immunostained preparations of complete series of brain sections, revealing markers of the fundamental stages in the life history of neuronal cells in very high quality preparations and photographic plates. Specific additions to this edition include documentation on the distribution of neurons expressing GABA, dopamine and serotonin, material on the basal ganglia, hypothalamus, and the caudal, segmented part of the diencephalon, new theories on the early organization of the telencephalon and thalamus, and integration of a comparative perspective on the mid- and hindbrain.
Автор: David M. Langenau Название: Cancer and Zebrafish ISBN: 3319306529 ISBN-13(EAN): 9783319306520 Издательство: Springer Рейтинг: Цена: 28734.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume focuses on defining the unique attributes of using the zebrafish cancer model for discovering important pathways and potential drug targets for the treatment of human cancers.
Автор: Detrich, III, H. William Название: The Zebrafish: Disease Models and Chemical Screens,105 ISBN: 0128034734 ISBN-13(EAN): 9780128034736 Издательство: Elsevier Science Рейтинг: Цена: 22570.00 р. Наличие на складе: Поставка под заказ.
Описание: The Zebrafish: Disease Models and Chemical Screens, Fourth Edition, the latest volume in the Methods in Cell Biology series, looks at methods for analyzing genetics, genomics, and transcriptomics of zebrafish. Chapters cover such topics as gene-trap mutagenesis, genetic screens for mutations, gene editing in zebrafish, homologous gene targeting, genome-wide RNA tomography, developmental epigenetics, and the zebrafish interactome. * Covers sections on model systems and functional studies, imaging-based approaches, and emerging studies* Includes chapters written by experts in the field* Contains cutting-edge material on the topics discussed
Автор: Langenau David M. Название: Cancer and Zebrafish: Mechanisms, Techniques, and Models ISBN: 3319808605 ISBN-13(EAN): 9783319808604 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume focuses on defining the unique attributes of using the zebrafish cancer model for discovering important pathways and potential drug targets for the treatment of human cancers. Using the zebrafish model, the volume explores oncogene and tumor suppressor discovery, chemical genetic approaches, genomics, epigenetics, cancer imaging, and cell transplantation. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish cancer models, including T cell leukemia, rhabdomyosarcoma, liver and pancreatic cancer, melanoma, neuroblastoma, germ cell tumors, and malignant peripheral sheath tumors. A chapter is also dedicated to the development and utilization of other piscine models of cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and cancer, providing a much needed resource on the powerful attributes of the zebrafish model system.
Автор: Raul Delgado-Morales Название: Stem Cell Genetics for Biomedical Research ISBN: 3030080765 ISBN-13(EAN): 9783030080761 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Поставка под заказ.
Описание: This book looks at where stem cell technology is presently and how it is instrumental in advancing the field of disease modeling and cell transplantation. By focusing on major human disorders such as Alzheimer’s disease, cancer, and heart disorders, the book summarizes the major findings in the field of human stem cells and dissect the current limitations on our understanding of stem cells biology. The chapters focus on the genetics, genomics, epigenetics and physiology of stem cells models, together with technological advances on molecular biology such as CRISPR/Cas9 or epigenetic editing, that will be instrumental in the future of human disease modeling and treatment. In base of the limitations of current disease models and in front of the unmet necessity of finding therapeutical interventions for human disorders, the availability of stem cell technology has opened new doors for several fields. The unlimited self-renewal capacity and more extensive differentiation potential of stem cells offers a theoretically inexhaustible and replenishable source of any cell subtype. Since Professor Shinya Yamanaka described it, 10 years ago in his seminal paper, that somatic cells could be reprogrammed to inducible stem cells (iPSC) just by expressing four transcription factors, the field of has exploded, especially its applications in biomedical research.
Автор: Sobti Название: Biomedical Translational Research ISBN: 9811692319 ISBN-13(EAN): 9789811692314 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book, which is the third volume of Biomedical translational research, focuses on the fundamental role of biomedical research in developing new medicinal products. Further, the book comprehensively reviews different computational approaches that employ GWAS data to guide drug repositioning.
Автор: d`Angelo, Livia Название: Laboratory Fish In Biomedical Research ISBN: 0128210990 ISBN-13(EAN): 9780128210994 Издательство: Elsevier Science Рейтинг: Цена: 21054.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Second novel in the chilling and epic new fantasy series from the bestselling and critically-acclaimed author of PRINCE OF THORNS and RED SISTER. `If you like dark you will love Mark Lawrence. And when the light breaks through and it all makes sense, the contrast is gorgeous` ROBIN HOBB
Автор: Sobti Название: Biomedical Translational Research ISBN: 9811688443 ISBN-13(EAN): 9789811688447 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The second volume of the Biomedical translational research discusses advancements in biomedical research for understanding the pathophysiology of various diseases towards improving diagnosis and treatment. It also illuminates novel strategies for heart failure diagnosis and therapeutic approaches for the treatment of heart failure.
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