Mechanisms of DNA Recombination and Genome Rearrangements: Intersection between Homologous Recombination, DNA Replication and DNA Repair, Volume 601, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field.
Homologous genetic recombination remains the most enigmatic process in DNA metabolism. The molecular machines of recombination preserve the integrity of the genetic material in all organisms and generate genetic diversity in evolution. The same molecular machines that support genetic integrity by orchestrating accurate repair of the most deleterious DNA lesions, however, also promote survival of cancerous cells and emergence of radiation and chemotherapy resistance. This two-volume set offers a comprehensive set of cutting edge methods to study various aspects of homologous recombination and cellular processes that utilize the enzymatic machinery of recombination. The chapters are written by the leading researches and cover a broad range of topics from the basic molecular mechanisms of recombinational proteins and enzymes to emerging cellular techniques and drug discovery efforts.
contributions by the leading experts in the field of DNA repair, recombination, replication and genome stability
documents cutting edge methods
Название: Dna replication-repair interface ISBN: 0323907334 ISBN-13(EAN): 9780323907330 Издательство: Elsevier Science Рейтинг: Цена: 23244.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Replication-Coupled Repair, Volume 661 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including the Repair of replication-born DNA breaks by sister chromatid recombination, High resolution and high throughput DNA cyclization measurements to interrogate DNA bendability, A programmable detection method for genomic signatures: from disease diagnosis to genome editing, Characterization of the telomerase modulating activities of yeast DNA helicases, Eukaryotic DNA replication with purified budding yeast proteins, Single molecule studies of yeast Rad51 paralogs, Light activation and deactivation of Cas9 for DNA repair studies, and more.
Other chapters explore MIDAS: Direct sequencing to map mitotic DNA synthesis and common fragile sites at high precision, Studying the DNA damage response in embryonic systems, GLASS-ChIP to map Mre11 cleavage sites in the human genome, New chemical biology approaches to trap reaction intermediates in living cells, Single-molecule imaging approaches for monitoring replication fork conflicts at genomic DNA G4 structures and R-loops in human cells, Monitoring the replication of structured DNA through heritable epigenetic change, Visualizing replication fork encounters with DNA interstrand crosslinks, and much more.
Автор: Huidong Zhang Название: DNA Replication - Damage from Environmental Carcinogens ISBN: 9401772118 ISBN-13(EAN): 9789401772112 Издательство: Springer Рейтинг: Цена: 7685.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book reviews the main concepts concerning DNA damage due to environmental carcinogens, the effects of DNA damage on DNA replication using a single DNA polymerase or DNA replisome, and the effects of carcinogens on various cell activities. It also introduces the detailed protocols for bypassing DNA damage. As we know, various environmental carcinogens are produced as a result of industry, agriculture, chemical engineering and vehicle exhaust in our daily life. It has been reported that the environmental carcinogens can be connected to tumors and cancer, directly threatening human health. In this regard, DNA replication is highly susceptible to damage. This book provides graduate students and researchers with an overview of the effects of environmental carcinogens on DNA replication and biological activities in cells. It offers important information for research in the areas of biochemistry, cell biology, medicine, toxicology and public health.
Автор: T.R. Lindahl; S.C. West Название: DNA Repair and Recombination ISBN: 940104239X ISBN-13(EAN): 9789401042390 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: New research shows that human cells use DNA repair mechanisms that are analogous to those found in bacteria to overcome the damaging effects of environmental mutagens and carcinogens.
Автор: Hideo Tsubouchi Название: DNA Recombination ISBN: 1493957783 ISBN-13(EAN): 9781493957781 Издательство: Springer Рейтинг: Цена: 23058.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Divided into four convenient sections, DNA Recombination: Methods and Protocols covers recent techniques that best utilize the advantages of the yeast system. With its well-honed methodologies, the book is as an ideal guide to scientists of all backgrounds.
Автор: V. V. Kushev Название: Mechanisms of Genetic Recombination ISBN: 1475758022 ISBN-13(EAN): 9781475758023 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Andr?s Aguilera; Rodney Rothstein Название: Molecular Genetics of Recombination ISBN: 3642090052 ISBN-13(EAN): 9783642090059 Издательство: Springer Рейтинг: Цена: 61352.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This work offers a fascinating insight into a crucial genetic process. It provides in-depth and up-to-date analysis of the chapter topics, and has been written by international experts in the field.
Автор: Richard Egel; Dirk-Henner Lankenau Название: Recombination and Meiosis ISBN: 3540689834 ISBN-13(EAN): 9783540689836 Издательство: Springer Рейтинг: Цена: 44582.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Together with the preceding volume in the series, this book covers all major aspects of meiotic research. Evolutionary subjects related to meiosis are treated. The chapters are written by expert researchers who have significantly contributed to their fields.
Автор: Rhoda Grell Название: Mechanisms in Recombination ISBN: 1468421352 ISBN-13(EAN): 9781468421354 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The topic of the symposium was Mechanisms in Recombination and it follows by exactly twenty years the previous Gatlinburg Symposium on Genetic Recombination. This symposium brought together individuals studying recombi- nation in organisms as widely separated as bacteriophage and mammals and using disciplinary approaches of comparable diversity.
Автор: Andr?s Aguilera; Aura Carreira Название: Homologous Recombination ISBN: 1071606433 ISBN-13(EAN): 9781071606438 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Human trafficking is one of the most pressing social justice issues of our time. Though renewed interest in this issue among Christians is a wonderful thing, misinformed and misguided efforts can do more harm than good. Written by seasoned leaders and grounded in theology and up-to-date data, this accessible and compelling handbook will educate churches and organizations for truly effective work.
Автор: Basha, Mahin Название: Homologous Recombination ISBN: 1071606468 ISBN-13(EAN): 9781071606469 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume details protocols encompassing different aspects of computer aided design and manufacturing of 3D scaffolds and biofabricated constructs for tissue engineering applications.
Название: Initiation of dna replication in eukaryotes ISBN: 3319246941 ISBN-13(EAN): 9783319246949 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: ГЇВїВЅ Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells. The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells.
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