Автор: Patrick Hughes; Ellen Fanning; Masamichi Kohiyama Название: DNA Replication: The Regulatory Mechanisms ISBN: 364276990X ISBN-13(EAN): 9783642769900 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: DNA replication is a key event in the cell cycle. On the other hand, considerableadvances have been made in our understanding of virus DNAreplication and this continues to deepen and broaden ourunderstanding of the controls of cellular DNA replication.
Описание: Introduction.- Optimal Origin Placement for Minimal Replication Time.- Actively Replicating Domains Randomly Associate into Replication Factories.- Summary and Conclusions.
Автор: Hanaoka Название: DNA Replication, Recombination, and Repair ISBN: 4431567178 ISBN-13(EAN): 9784431567172 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Поставка под заказ.
Описание: This book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to maintain and sometimes intentionally alter genetic information. DNA replication, recombination, and repair, individually, have been important subjects of molecular biology since its emergence, but we have recently become aware that the 3Rs are actually much more intimately related to one another than we used to realize. Furthermore, the 3R research fields have been growing even more interdisciplinary, with better understanding of molecular mechanisms underlying other important processes, such as chromosome structures and functions, cell cycle and checkpoints, transcriptional and epigenetic regulation, and so on. This book comprises 7 parts and 21 chapters: Part 1 (Chapters 1–3), DNA Replication; Part 2 (Chapters 4–6), DNA Recombination; Part 3 (Chapters 7–9), DNA Repair; Part 4 (Chapters 10–13), Genome Instability and Mutagenesis; Part 5 (Chapters 14–15), Chromosome Dynamics and Functions; Part 6 (Chapters 16–18), Cell Cycle and Checkpoints; Part 7 (Chapters 19–21), Interplay with Transcription and Epigenetic Regulation. This volume should attract the great interest of graduate students, postdoctoral fellows, and senior scientists in broad research fields of basic molecular biology, not only the core 3Rs, but also the various related fields (chromosome, cell cycle, transcription, epigenetics, and similar areas). Additionally, researchers in neurological sciences, developmental biology, immunology, evolutionary biology, and many other fields will find this book valuable.
Mechanisms of DNA Recombination and Genome Rearrangements: Intersection between Homologous Recombination, DNA Replication and DNA Repair, Volume 601, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field.
Homologous genetic recombination remains the most enigmatic process in DNA metabolism. The molecular machines of recombination preserve the integrity of the genetic material in all organisms and generate genetic diversity in evolution. The same molecular machines that support genetic integrity by orchestrating accurate repair of the most deleterious DNA lesions, however, also promote survival of cancerous cells and emergence of radiation and chemotherapy resistance. This two-volume set offers a comprehensive set of cutting edge methods to study various aspects of homologous recombination and cellular processes that utilize the enzymatic machinery of recombination. The chapters are written by the leading researches and cover a broad range of topics from the basic molecular mechanisms of recombinational proteins and enzymes to emerging cellular techniques and drug discovery efforts.
contributions by the leading experts in the field of DNA repair, recombination, replication and genome stability
documents cutting edge methods
Название: DNA Replication Stress ISBN: 303921389X ISBN-13(EAN): 9783039213894 Издательство: Неизвестно Рейтинг: Цена: 13169.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid transactions to maintain genomic stability and cellular homeostasis. A total of 18 articles are presented which encompass a broad range of highly relevant topics in genome biology. These include replication fork dynamics, DNA repair processes, DNA damage signaling and cell cycle control, cancer biology, epigenetics, cellular senescence, neurodegeneration, and aging.
As Guest Editor for this IJMS
Автор: Ellen Fanning; Rolf Knippers; Ernst-L. Winnacker Название: DNA Replication and the Cell Cycle ISBN: 3642770428 ISBN-13(EAN): 9783642770425 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Provided here is an easily accessible introduction to themechanisms of DNA replication, regulation and thebiochemistry of cell cycle control.
Автор: Huidong Zhang Название: DNA Replication - Damage from Environmental Carcinogens ISBN: 9401772118 ISBN-13(EAN): 9789401772112 Издательство: Springer Рейтинг: Цена: 7685.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book reviews the main concepts concerning DNA damage due to environmental carcinogens, the effects of DNA damage on DNA replication using a single DNA polymerase or DNA replisome, and the effects of carcinogens on various cell activities. It also introduces the detailed protocols for bypassing DNA damage. As we know, various environmental carcinogens are produced as a result of industry, agriculture, chemical engineering and vehicle exhaust in our daily life. It has been reported that the environmental carcinogens can be connected to tumors and cancer, directly threatening human health. In this regard, DNA replication is highly susceptible to damage. This book provides graduate students and researchers with an overview of the effects of environmental carcinogens on DNA replication and biological activities in cells. It offers important information for research in the areas of biochemistry, cell biology, medicine, toxicology and public health.
Автор: Hisao Masai; Marco Foiani Название: DNA Replication ISBN: 981134972X ISBN-13(EAN): 9789811349720 Издательство: Springer Рейтинг: Цена: 23058.00 р. Наличие на складе: Поставка под заказ.
Описание: This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field. The following chapters include genome-wide studies of replication origins and initiation factor binding, as well as the timing of DNA replications, mechanisms of initiation, DNA chain elongation and termination of DNA replication, the structural basis of functions of protein complexes responsible for execution of DNA replication, cell cycle-dependent regulation of DNA replication, the nature of replication stress and cells’ strategy to deal with the stress, and finally how all these phenomena are interconnected to genome instability and development of various diseases. By reviewing the existing concepts ranging from the old principles to the newest ideas, the book gives readers an opportunity to learn how the classical replication principles are now being modified and new concepts are being generated to explain how genome DNA replication is achieved with such high adaptability and plasticity. With the development of new methods including cryoelectron microscopy analyses of huge protein complexes, single molecular analyses of initiation and elongation of DNA replication, and total reconstitution of eukaryotic DNA replication with purified factors, the field is enjoying one of its most exciting moments, and this highly timely book conveys that excitement to all interested readers.
Описание: DNA Replication: Mechanisms, Epigenetics, and Gene Therapy Applications presents the latest trends of DNA replication research by reviewing the fundamentals of molecular mechanisms of initiation and termination, functional cross-talk and/or association to the genome, DNA recombination and repair, analytical methods, recent applications, and future directions in the field. This book brings together and synthesizes contributions from active and prominent researchers in the field whose chapters address such topics as basic molecular biology, cell growth and division, DNA isolation and duplication, DNA damage response, epigenetics, DNA methylation, gene silencing, analytical and computational tools, and much more.
Автор: Tsanev, Roumen G. Название: Replication and Transcription of Chromatin ISBN: 0849368030 ISBN-13(EAN): 9780849368035 Издательство: Taylor&Francis Рейтинг: Цена: 56654.00 р. Наличие на складе: Поставка под заказ.
Описание: Viral Replication Enzymes and their Inhibitors, Part B, Volume 50 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics surrounding enzymes.
