Автор: Bradley J. Название: Nelson`s Pediatric Antimicrobial Therapy 2022. 28 ed. ISBN: 1610025644 ISBN-13(EAN): 9781610025645 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 6930.00 р. Наличие на складе: Нет в наличии.
Описание: Completely updated and revised, the 28th edition of this best-selling reference provides instant access to the latest recommendations for treatment of infectious diseases in children. For each disease, the authors provide a commentary to help select the best of all antimicrobial choices.
Автор: Bueno Juan Название: Preclinical Evaluation of Antimicrobial Nanodrugs ISBN: 3030438570 ISBN-13(EAN): 9783030438579 Издательство: Springer Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Translational medicine addresses the gap between research and the clinical application of new discoveries. To efficiently deliver new drugs to care centers, a preclinical evaluation, both in vitro and in vivo, is required to ensure that the most active and least toxic compounds are selected as well as to predict clinical outcome. Antimicrobial nanomedicines have been shown to have higher specificity in their therapeutic targets and the ability to serve as adjuvants, increasing the effectiveness of pre-existing immune compounds. The design and development of new standardized protocols for evaluating antimicrobial nanomedicines is needed for both the industry and clinical laboratory. These protocols must aim to evaluate laboratory activity and present models of pharmacokinetic-pharmacodynamic and toxicokinetic behavior that predict absorption and distribution. Likewise, these protocols must follow a theranostics approach, be able to detect promising formulations, diagnose the infectious disease, and determine the correct treatment to implement a personalized therapeutic behavior. Given the possibilities that nanotechnology offers, not updating to new screening platforms is inadequate as it prevents the correct application of discoveries, increasing the effect of the valley of death between innovations and their use.
This book is structured to discuss the fundamentals taken into account for the design of robust, reproducible and automatable evaluation platforms. These vital platforms should enable the discovery of new medicines with which to face antimicrobial resistance (RAM), one of the great problems of our time.
Автор: Ockelford, Adam Gray, Sophie Cohen, Jon Mai, Max Название: Antimicrobials in Pharmaceutical and Medicinal Research ISBN: 1032215534 ISBN-13(EAN): 9781032215532 Издательство: Taylor&Francis Рейтинг: Цена: 19140.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book deliberates recent developments in microbial science in combating infectious diseases and explores advances in antimicrobial constituents and their applications in the fight against bacteria.
Описание: The increasing prevalence of antibiotic-resistant bacteria, known as superbugs, has threatened the field of infectious disease medicine over most of the past century. Antimicrobial peptides, a crucial part of innate immunity that exists in most living organisms, have become a central pillar for the next generation of medical challenges for infectious diseases, cancer, and other health problems. The development of new antimicrobial peptides to tackle ongoing superbug infections, cancer and other diseases is a fast-growing research area for chemistry, medical physics, biological science, food and agricultural science and different disciplines of medicine. This volume discusses the basic science behind potential pharmacological agents, which is necessary to understand how these peptides can be used in our daily lives. The book provides a foundation for a wide variety of antimicrobial peptide-based therapeutic approaches, which is invaluable for established scientists, junior researchers, and students involved in basic science, material science, the medical field and different disciplines of engineering. It contains nine chapters written by world leaders in this area, covering basic science and possible therapeutic applications with immense societal implications. Antimicrobial peptides are an exciting new therapeutic agent with promising applications for a wide variety of illnesses.
Автор: Paul Robert Hansen Название: Antimicrobial Peptides ISBN: 1493967355 ISBN-13(EAN): 9781493967353 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume provides basic and advanced laboratory protocols for the non-specialist and the experienced researcher. Chapters are divided into three parts covering synthesis and characterization of AMPs, studying the interaction of AMPs with model systems or bacteria, and assaying selected biological activities of AMPs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Antimicrobial Peptides: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Автор: Djamel Drider; Sylvie Rebuffat Название: Prokaryotic Antimicrobial Peptides ISBN: 1489994777 ISBN-13(EAN): 9781489994776 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book will provide an overview of the advancement of fundamental knowledge and applications of antimicrobial peptides in biomedical, agricultural, veterinary, food, and cosmetic products.
Название: Antimicrobial peptides ISBN: 1493982877 ISBN-13(EAN): 9781493982875 Издательство: Springer Рейтинг: Цена: 16070.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Part I: Properties, Design, Synthesis and Characterization of AMPs
1. Antimicrobial Peptides: An Introduction
Evan F. Haney, Sarah C. Mansour, and Robert E.W. Hancock
2. Tools for Designing Amphipathic Helical Antimicrobial Peptides
Davor Juretic, Damir Vukičevic, and Alessandro Tossi
3. Chemical Synthesis of Antimicrobial Peptides
Lena Mьnzker, Alberto Oddo and Paul R. Hansen
4. Microwave-Assisted Synthesis of Antimicrobial Peptides
Suhas Ramesh, Beatriz G. de la Torre, Fernando Albericio, Hendrik G. Kruger, and Thavendran Govender
5. High Performance Liquid Chromatography and Mass Spectrometry-Based Design of Protolytically Stable Antimicrobial Peptides
Mojtaba Bagheri and Robert E. W. Hancock
6. Determination of Structure and Micellar Interactions of Small Antimicrobial Peptides by Solution-State NMR
Reinhard Wimmer and Lars Erik Uggerh j
7. Mass Spectrometry Approaches for Determining the Structure of Antimicrobial Peptides
Jiongyu Liu and Jianping Jiang
Part II: Studying Interactions of AMPs with Model Membranes and Bacteria
8. Molecular Dynamics Simulation and Analysis of the Antimicrobial Peptides-Lipid Bilayers Interactions
Shima Arasteh and Mojtaba Bagheri
9. Calorimetry Methods to Study Membrane Interactions and Perturbations Induced by Antimicrobial Host Defense Peptides
Mauricio Arias, Elmar J. Prenner and Hans J. Vogel
10. Fluorescence and Absorbance Spectroscopy Methods to Study Membrane Perturbations by Antimicrobial Host Defense Peptides
Mauricio Arias and Hans J. Vogel
11. Applying Fluorescence Correlation Spectroscopy to Investigate Peptide-Induced Membrane Disruption
Kasper Kristensen, Jonas R. Henriksen, and Thomas L. Andresen
12. Macromolecule Biosynthesis Assay and Fluorescence Spectroscopy Methods to Explore Antimicrobial Peptide Mode(s) of Action
Bimal Jana, Kristin Renee Baker, and Luca Guardabassi
13. Using Confocal Microscopy and Computational Modeling to Investigate the Cell Penetrating Properties of Antimicrobial Peptides
Gabriel Del Rio, Edda Klipp, and Andreas Herrmann
14. Atomic Force Microscopy Study of the Interactions of Indolicidin with Model Membranes and DNA
Peter Fojan and Leonid Gurevich
15. Protocols for studying the interaction of MSI-78 with the Membranes of Whole Gram-positive and Gram-negative Bacteria by NMR
Nury P. Santisteban, M. R. Morrow, and V. Booth
16. Preparation of membrane models of Gram-negative bacteria and their interaction with Antimicrobial Peptides studied by CD and NMR
Rickey P. Hicks
17. Studying the Interaction of Magainin 2 and Cecropin A with E. coli Bacterial Cells using Circular Dichroism
Concetta Avitabile, Luca Domenico D'Andrea and Alessandra Romanelli
18. Studying the Mechanism of Membrane Permeabilization induced by Antimicrobial Peptides using Patch-clamp Techniques
Giorgio Rispoli
19. Assays for Identifying Inducers of the Antimicrobial Peptide LL-37
Frank Nylen, Peter Bergman, Gudmundur H. Gudmundsson, and Birgitta Agerberth
20. Methods for Elucidating the Mechanism of Action of Proline-rich and other Non-lytic Antimicrobial Peptides
Monica Benincasa, Giulia Runti, Mario Mardirossian, Renato Gennaro, and Marco Scocchi
21. The Interaction of Antimicrobial Peptides with the Membrane and Intracellular Targets of Staphylococcus Aureus Investigated by ATP-leakage, DNA-binding Analysis and the Expression of a LexA Controlled Gene, recA
Sanne Gottschalk and Line Elnif Thomsen
Part III: Assaying Selected
Автор: Andrea Giuliani; Andrea C. Rinaldi Название: Antimicrobial Peptides ISBN: 1607615932 ISBN-13(EAN): 9781607615934 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this book, leading investigators present a broad, up-to-date collection of current research and experimental methods for the isolation, characterization, production, and optimization of AMPs. The book covers a rapidly expanding field of research.
Автор: Jeffrey K. Aronson Название: Meyler`s Side Effects of Antimicrobial Drugs, ISBN: 0444532722 ISBN-13(EAN): 9780444532725 Издательство: Elsevier Science Рейтинг: Цена: 8420.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Suitable for internal medicine physicians and general practitioners who prescribe antibiotic drugs, like penicillin and tetracycline that cure bacterial infections, and antiviral drugs used to treat patients with HIV and herpes viruses.
Автор: T. J. Franklin Название: Biochemistry of Antimicrobial Action ISBN: 9401068577 ISBN-13(EAN): 9789401068574 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The rapid advances made in the study of the synthesis, structure and function of biological macromolecules in the last fifteen years have enabled scientists concerned with antimicrobial agents to achieve a considerable measure of understanding of how these substances inhibit cell growth and division.
Автор: Abia Название: Antimicrobial Research and One Health in Africa ISBN: 3031237951 ISBN-13(EAN): 9783031237959 Издательство: Springer Рейтинг: Цена: 30745.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Antimicrobial resistance is recognised among the world’s most challenging problems. Despite its global spread, Africa, specifically sub-Saharan Africa, is the most affected by this malaise. Poor living conditions and inadequate access to sanitation and potable water supplies are among contributing factors that have influenced a high disease burden on the continent, requiring extensive antimicrobials. Weak health systems and the absence of firm policies further aggravate the problem, as the use of antimicrobials is mostly unregulated. The increasing demand for animal protein to meet the starving populations’ demands has also influenced the use of these antimicrobials, including those banned on other continents, for food animal production. The ripple effect of indiscriminate use in humans and animals is the massive discharge of antimicrobials, their residues, antimicrobial-resistant microorganisms and their associated genes into the environment. This 14-chapter unique masterpiece presents the AMR problem in African, addressing the various compartments of the One Health – humans, animals, and the environment, to illustrate the need for concerted efforts in the fight against AMR, especially in Africa. Authors from the four cardinal points present diverse aspects of AMR in Africa, starting with behavioural and social drivers of AMR in Africa. Antimicrobial stewardship in an African context is also discussed. AMR in humans is presented through studies on antibiotic-resistant neonates and nontyphoidal Salmonella infections and the clinical relevance of the genetics of viral resistance. Topics on AMR in mastitis, biosecurity in animal farming and the linkage between disinfectants and AMR are discussed. The environmental dimension of AMR is discussed, notably in the aquatic environment, and its implication for aquaculture and irrigation and using nanomaterials to treat polluted waters from such environments are highlighted. Finally, Africa’s rich floral diversity is portrayed as an eco-friendly and cost-effective approach to combat AMR. Hopefully, the work presented will spur greater collaboration between scientists, environmental, animal and human health practitioners, the general population, and policymakers to assimilate and implement the One Health approach to combating AMR, rather than working in silos on their various sectors
Автор: Samanta, Indranil Название: Antimicrobial Resistance In Agriculture ISBN: 0128157704 ISBN-13(EAN): 9780128157701 Издательство: Elsevier Science Рейтинг: Цена: 16161.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Antimicrobial Resistance in Agriculture: Perspective, Policy and Mitigation is a valuable industrial resource that addresses complex, multi-factorial topics regarding farm, wild, companion animals, fish, and how the environment plays an important role in amplification and transmission of resistant bugs into the human food chain. Information of phenotypical and genotypical properties of each bacterial genus associated with antimicrobial resistance, transmission dynamics from different reservoirs (food animals, poultry, fishes) and control measures with alternative therapy, such as phytobiotics and nanomaterials are provided. Researchers, scientists and practitioners will find this an essential resource on the judicial use of antibiotics in animals and humans.
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