Gene Delivery, Floyd, Kory (University of Arizona, USA) Schrodt, Paul Erbert, Larry A. (University Colorado Denver, USA) Scharp, Kristina M. (University of Washington, USA)
This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.
This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Автор: Ambikanandan Misra Название: Challenges in Delivery of Therapeutic Genomics and Proteomics, ISBN: 0123849640 ISBN-13(EAN): 9780123849649 Издательство: Elsevier Science Рейтинг: Цена: 15681.00 р. 22401.00-30% Наличие на складе: Есть (1 шт.) Описание: Delivery of therapeutic proteomics and genomics represent an important area of drug delivery research. Genomics and proteomics approaches could be used to direct drug development processes by unearthing pathways involved in disease pathogenesis where intervention may be most successful. This book describes the basics of genomics and proteomics and highlights the various chemical, physical and biological approaches to protein and gene delivery.
Автор: Mishra Название: Nanomedicine for Drug Delivery and Therapeutics ISBN: 1118414098 ISBN-13(EAN): 9781118414095 Издательство: Wiley Рейтинг: Цена: 20507.00 р. 29296.00-30% Наличие на складе: Есть (1 шт.) Описание: This book describes a broad area of nanomedicine which involves mainly applications, diseases, and diagnostics. The comprehensive coverage provides researchers, academics, and health specialists with a great tool, that includes techniques applicable to various uses.
Название: Gene delivery: methods and applications ISBN: 153616268X ISBN-13(EAN): 9781536162684 Издательство: Nova Science Рейтинг: Цена: 13462.00 р. Наличие на складе: Невозможна поставка.
Описание: Gene Delivery: Methods and Applications provides a comprehensive overview on viral and non-viral methods used to genetically engineer human mesenchymal stromal cells. In addition, an update on ongoing and completed clinical studies with engineered mesenchymal stromal cells will be provided, as well as a snapshot of the advances and technical challenges yet to be addressed. Next, a variety of gene delivery systems including physical transfection techniques, virus-based delivery vectors, chemically engineered delivery systems and bio-inspired vehicles are reviewed and their strengths, shortcomings and biomedical applications are discussed. Selfish DNA called transposons capable of cutting out and pasting into the host genome are active throughout the phylogenetic kingdoms. Researchers have repurposed natural transposons for use in delivering a gene-of-interest, enabling for the study of a large and growing list of preclinical gene therapy applications. As such, the authors discuss the past achievements and future challenges of this early-stage technology. The closing chapter introduces cell-penetrating peptides as an efficient tool for DNA transfection. HR9, a designed cell-penetrating peptides, containing nona-arginine flanked by cysteine and penta-histidine displayed a high penetrating ability in mammalian cells.
Автор: Lasic, Danilo D. , Barenholz, Yechezkel Название: Handbook of Nonmedical Applications of Liposomes ISBN: 0367261022 ISBN-13(EAN): 9780367261023 Издательство: Taylor&Francis Рейтинг: Цена: 27562.00 р. Наличие на складе: Поставка под заказ.
Описание: First published in 1996, liposomes have become an important model in fundamental biomembrane research, including biophysical, biochemical, and cell biological studies of membranes and cell function. In these volumes many of the top experts contribute extensive reviews of their work.
Автор: Lasic, Danilo D. , Barenholz, Yechezkel Название: Handbook of Nonmedical Applications of Liposomes ISBN: 0367261049 ISBN-13(EAN): 9780367261047 Издательство: Taylor&Francis Рейтинг: Цена: 8726.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: First published in 1996, liposomes have become an important model in fundamental biomembrane research, including biophysical, biochemical, and cell biological studies of membranes and cell function. In these volumes many of the top experts contribute extensive reviews of their work.
Автор: Goldstein, Aaron S. Название: Biomaterials for Cell Delivery ISBN: 0367732335 ISBN-13(EAN): 9780367732332 Издательство: Taylor&Francis Рейтинг: Цена: 7961.00 р. Наличие на складе: Поставка под заказ.
Название: Biotechnology in the modern medicinal system ISBN: 1771889721 ISBN-13(EAN): 9781771889728 Издательство: Taylor&Francis Рейтинг: Цена: 20059.00 р. Наличие на складе: Поставка под заказ.
Описание: Presents an informative picture of the state-of-the-art research and development of actionable knowledge in medical biotechnology, specifically involving gene therapy, immunotherapy, and targeted drug delivery systems.
Название: Gene delivery systems ISBN: 1032025506 ISBN-13(EAN): 9781032025506 Издательство: Taylor&Francis Рейтинг: Цена: 19906.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume covers the development of gene therapy, the technology involved, clinical applications of siRNA, non-viral vector-based mRNA delivery using nanotechnology, and RNA based vaccines for treating the infectious diseases.
Автор: Anil Kumar Bajpai, Rajesh Saini, Abhilasha Mishra, Jaya Kumar Bajpai, Atul Tiwari Название: Stimuli-Responsive Drug Delivery Systems: From Introduction to Application ISBN: 1501518836 ISBN-13(EAN): 9781501518836 Издательство: Walter de Gruyter Цена: 14495.00 р. Наличие на складе: Нет в наличии.
Описание:
Stimuli responsive drug delivery systems have emerged as one of the most innovative classes of polymer materials of modern materials science. The book offers a convincing approach to understanding the basic principles of drug delivery process, their mathematical modeling, different types of drug delivery systems, various polymer systems responsive to stimuli such as swelling, pH, temperature, light, chemical agents, electric and magnetic fields.
Автор: Gregory Gregoriadis; Brenda McCormack Название: Targeting of Drugs 5 ISBN: 1461379431 ISBN-13(EAN): 9781461379430 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of a NATO ASI held in Cape Sounion, Greece, June 24-July 5, 1995
Название: Nanoparticulate vaccine delivery systems ISBN: 9814613304 ISBN-13(EAN): 9789814613309 Издательство: Taylor&Francis Рейтинг: Цена: 17609.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Recent years have seen the development of novel technologies that use nanoparticles and microparticles to deliver vaccines by the oral and microneedle-based transdermal route of administration. These new technologies enable the formulation of vaccine particles containing vaccine antigens, without loss of their biological activity during the formulation process. Also, multiple antigens, targeting ligands, and adjuvants can all be encapsulated within the same particle. When administered orally, these particles are designed to withstand the acidic environment of the stomach and are targeted to Peyer's patches and the gut-associated mucosal immune system. Since these vaccines are particulate in nature, they are readily taken up by phagocytic antigen-presenting cells, such as M cells, dendritic cells, and macrophages in Peyer's patches of the intestines, resulting in a strong immune response and antibody production. Since no needles are required for oral vaccines, this method of vaccine delivery is inexpensive and suitable for mass vaccination in the developing world as well as the developed world. This book discusses studies conducted on a wide array of vaccines, including vaccines for infectious diseases such as tuberculosis, typhoid, influenza, pneumonia, meningitis, human papillomavirus, and hepatitis B. It also discusses recent studies on vaccines for cancers such as melanoma and ovarian, breast, and prostate cancer.
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