Cyclic Nucleotide Signaling, Michael, Michaelis

Автор: John T. Turner; Gary A. Weisman; Jeffrey S. Fedan
Название: The P2 Nucleotide Receptors
ISBN: 1461272890 ISBN-13(EAN): 9781461272892
Издательство: Springer
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Описание: A state-of-the-art summary from leading laboratories around the world of our current knowledge of the molecular biology, the physiology, and the pharmacology of the P2 receptors.

Автор: Tavassoli Ali
Название: Inhibitors of Protein-Protein Interactions: Small Molecules, Cyclic Peptides, Macrocycles and Antibodies
ISBN: 178801569X ISBN-13(EAN): 9781788015691
Издательство: Royal Society of Chemistry
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Описание: Illustrated throughout with successful case studies, this book provides a holistic, cutting-edge view of the subject area and is ideal for chemical biologists and medicinal chemists interested in developing PPI inhibitors.

Автор: Hon Cheung Lee
Название: Cyclic ADP-Ribose and NAADP
ISBN: 1461349966 ISBN-13(EAN): 9781461349969
Издательство: Springer
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Описание: In the past decade we have witnessed the birth and maturing of a field of research centering on the Ca2+ signaling functions of cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), which structures and mechanisms of action are truly unique among all Ca2+ messengers.

Автор: Heinrich Schmidt-Gayk; Franz P. Armbruster; Roger
Название: Calcium Regulating Hormones, Vitamin D Metabolites, and Cyclic AMP Assays and Their Clinical Application
ISBN: 3662004089 ISBN-13(EAN): 9783662004081
Издательство: Springer
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Описание: Calcium metabolism is regulated by three specific hormones: parathor- mone, calciferol metabolites, and calcitonin. Cyclic AMP also plays an important part in calcium regulation, and its concentration in urine can be taken as a measure of parathyroid function. Methods for quantitative measurement of, e.g. calcium-regulating hormones and vitamin D metabolites as well as of cAMP are absolutely necessary for safe differential diagnosis of diseases of the parathyroid like hypo- and hyperparathyroidism. In this monograph all presently available methods are summarized as to whether they can already be obtained as test kits or are still being tested. Radioimmunoassays for the various peptide fragments such as 53-84, 44-68, 28-48, and 1-34 are described, as are immunochemiluminescence methods and adenylate cyclase bioassays. The same is true for the vitamin D metabolites, where the various assays for calcidiol and calcitriol such as HPLC, protein-binding assay with second antibody separation, and double antibody RIA are de scribed. Finally, determination of calcitonin and cAMP is discussed in detail. This is a practically and clinically oriented monograph for working in the fields of internal medicine, endocrinology, and laboratory medicine.

Название: Cyclic Peptides: From Bioorganic Synthesis to Applications
ISBN: 1782625283 ISBN-13(EAN): 9781782625285
Издательство: Royal Society of Chemistry
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Описание: This book provides the reader with a comprehensive view of the state-of-the-art of cyclic peptides, from construction to utility in biology and drug discovery.

Автор: Chou Shan-Ho, Guiliani Nicolas, Lee Vincent T.
Название: Microbial Cyclic Di-Nucleotide Signaling
ISBN: 3030333078 ISBN-13(EAN): 9783030333072
Издательство: Springer
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Цена: 18167.00 р.
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Описание:

Microbial Cyclic Di-Nucleotide Signaling

Chapter 21: Cyclic di-GMP signalingin extreme acidophilic bacteria (Castro Matнas, Dнaz Mauricio, Moy

Название: Cyclic Nucleotide Phosphodiesterases in Health and Disease
ISBN: 0367453320 ISBN-13(EAN): 9780367453329
Издательство: Taylor&Francis
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Цена: 9492.00 р.
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Описание:

Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research.

Cyclic Nucleotide Phosphodiesterases in Health and Disease provides an integrated volume covering PDE biology from genes to organisms. It examines phosphodiesterases as pharmacological targets as well as the development of specific PDE inhibitors as therapeutic agents. With contributions from pioneers in the field, individual chapters describe one of the 11 known mammalian PDE families including the molecular characteristics, structure, function, and traits unique to each. Characteristics of PDEs from lower organisms are also the subject of other chapters since they provide key insights into PDE functions and are also pharmacological targets for treatment of a variety of diseases in humans and domestic animals. Chapters on the current biomedical and therapeutic research on PDEs include studies on gene-targeted knockout strategies and compartmentation in cyclic nucleotide signaling. By unraveling the unique cellular roles for different PDEs, scientists are beginning to open the door to the therapeutic use of PDE inhibitors for the treatment of a number of pathological conditions including asthma and inflammation, pulmonary hypertension, erectile dysfunction, and stroke.

By collating current information into a coherent and coordinated perspective, Cyclic Nucleotide Phosphodiesterases in Health and Disease provides an invaluable reference for industry and clinical scientists and points toward future directions of research and therapeutic advancements in developing selective inhibitors for these various enzymes.

Автор: Seifert Roland
Название: Non-Canonical Cyclic Nucleotides
ISBN: 331984959X ISBN-13(EAN): 9783319849591
Издательство: Springer
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Описание: Lastly, the book will present important methodological aspects ranging from mass-spectrometric methods for cyclic nucleotide detection to the synthesis of nucleotide analogs as experimental tools and holistic methods for analysis of cyclic nucleotide effects.

Автор: Roland Seifert
Название: Non-canonical Cyclic Nucleotides
ISBN: 3319526715 ISBN-13(EAN): 9783319526713
Издательство: Springer
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Описание: Lastly, the book will present important methodological aspects ranging from mass-spectrometric methods for cyclic nucleotide detection to the synthesis of nucleotide analogs as experimental tools and holistic methods for analysis of cyclic nucleotide effects.

Автор: J. A. Nathanson; M.M. Appleman; J. W. Kebabian; M.
Название: Cyclic Nucleotides
ISBN: 3642681131 ISBN-13(EAN): 9783642681134
Издательство: Springer
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Цена: 18167.00 р.
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Описание: The purpose of the present volume, the first of two on the pharmacology, biochemistry, and physiology of cyclic nucleotides, is to provide a comprehensive and up-to-date anthology on the nature and role of these important chemical regulators.

Автор: L. Bosch
Название: The Guanine — Nucleotide Binding Proteins
ISBN: 1475720394 ISBN-13(EAN): 9781475720396
Издательство: Springer
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Цена: 6986.00 р.
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Описание: This volume contains the proceedings of the EMBO-NATO-CEC Advanced Research Workshop on "Guanine-nucleotide binding proteins. The cellular membrane, as the obligatory target for external signals, harbours complex pathways transducing the signals from the receptors of the external stimuli to the cytoplasmic effector.

Автор: Michael Fry; Karen Usdin
Название: Human Nucleotide Expansion Disorders
ISBN: 3642069975 ISBN-13(EAN): 9783642069970
Издательство: Springer
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Цена: 44582.00 р.
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Описание: Human neurological and neuromuscular disorders caused by nucleotide expansion are the focus of growing interest of practicing physicians and of interested biomedical researchers. The authors discuss molecular, clinical and pathological aspects of the diseases as well as our current understanding of their underlying mechanisms.