Автор: Malgorzata Kloc; Jacek Z. Kubiak Название: Marine Organisms as Model Systems in Biology and Medicine ISBN: 3030064425 ISBN-13(EAN): 9783030064426 Издательство: Springer Рейтинг: Цена: 39130.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This book highlights the potential advantages of using marine invertebrates like tunicates, echinoderms, sponges and cephalopods as models in both biological and medical research. Bioactive compounds found in marine organisms possess antibacterial, antifungal, anti-diabetic and anti-inflammatory properties, and can affect the immune and nervous systems. Despite substantial research on the medicinal attributes of various marine invertebrates, they are still very much underrepresented in scientific literature: the majority of cell, developmental and evolutionary scientific journals only publish research conducted on a few well-known model systems like Drosophila melanogaster or Xenopus laevis.
Addressing that gap, this book introduces readers to new model organisms like starfish or nemertera. By showing their benefits with regard to regeneration, stem cell research and Evo-Devo, the authors provide a cross-sectional view encompassing various disciplines of biological research. As such, this book will not only appeal to scientists currently working on marine organisms, but will also inspire future generations to pursue research of their own.
Автор: Saravanan Ramachandran; Senthilkumar Rajagopal Название: Zebrafish: A Model for Marine Peptide Based Drug Screening ISBN: 9811378436 ISBN-13(EAN): 9789811378430 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Поставка под заказ.
Описание: This book offers a comprehensive overview of toxicology, highlighting the significance of peptide-based toxins from marine environments. It discusses the principles of protein-carbohydrate and domain-domain interactions to increase our understanding of toxicology in zebrafish models, as well as drug interaction mechanisms and target definition in drug discovery. It also reviews the structure of marine peptides/toxins and the toxicology of peptide secreting cells and cells that respond to these enzymes, and describes the normal and abnormal toxicology of marine peptides in zebrafish models. Offering insights into the field of proteomics, particularly current practice and research models for solving its many riddles, the book also explains the analytical principles of marine protein-protein and protein-carbohydrate interaction in the context of teratogenicity in target identification in peptide- based drug discovery. Lastly, the book methodically examines the preclinical research on marine proteins/peptides.
Автор: Yuan, Lijuan (department Of Biomedical Sciences And Pathobiology, Virginia Tech, Blacksburg, Virginia, Usa) Название: Vaccine efficacy evaluation ISBN: 0367486342 ISBN-13(EAN): 9780367486341 Издательство: Taylor&Francis Рейтинг: Цена: 6736.00 р. Наличие на складе: Нет в наличии.
Описание: This book provides detailed information on establishing gnobiotic pig models, determining a proper virus inoculum pool and challenge dose, measuring protection and calculating efficacy, and delineating intestinal and systemic immune responses associated with the protection.
Автор: Gupta Deepak, Khamparia Aditya, Khanna Ashish Название: Soft Computing for Data Analytics, Classification Model, and Control ISBN: 3030920259 ISBN-13(EAN): 9783030920258 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Chapter 1: An Optimization of Fuzzy Rough Set Nearest Neighbor Classification Model using Krill Herd Algorithm for Sentiment Text Analytics.- Chapter 2: Fuzzy Wavelet Neural Network with Social Spider Optimization Algorithm for Pattern Recognition in Medical Domain.- Chapter 3: Fuzzy with Gravitational Search Algorithm Tuned Radial Basis Function Network for Medical Disease Diagnosis and Classification Model.- Chapter 4: Optimal Neutrosophic Rules based Feature Extraction for Data Classification using Deep Learning Model.- Chapter 5: Self-Evolving Interval Type-2 Fuzzy Neural Network Design for The Synchronization of Chaotic Systems.- Chapter 6: Categorizing Relations via Semi-Supervised Learning using a Hybrid Tolerance Rough Sets and Genetic Algorithm Approach.- Chapter 7: Data-driven Fuzzy C-Means Equivalent Turbine-governor for Power System Frequency Response.- Chapter 8: Multicriteria group decision making using a novel similarity measure for triangular fuzzy numbers based on their newly defined expected values and variances.- Chapter 9: Bangla Printed Character Generation from Handwritten Character Using GAN.
Описание: Part I: OverviewChapter 1: "An Overview of the Translational Dilemma and the Need for Model-based Precision Medicine" Yoram Vodovotz and Gary An Part II: "Computational Modeling Methods and Biomedical Applications"Chapter 2: Translational Equation-based Modeling -Gilles ClermontChapter 3: Agent-based Modeling in Translational Systems Biology -Gary An Chapter 4: Integrating Data-driven and Mechanistic Modeling in Sepsis and Trauma -Yoram VodovotzChapter 5: Therapeutics as Control: Model-based approaches for control discovery -Chase Cockrell, Judy Day, Gary An Part III: Translational Modeling of Sepsis and TraumaChapter 6: Disorder of Systemic Inflammation in Sepsis and Trauma: A Systems Perspective -Tim Billiar Chapter 7: Multiscale Equation-based Models: Insights for Inflammation and Physiological Variability -Ioannis AndroulakisChapter 8: In silicoTrials and Personalized Therapy for Sepsis and Trauma -Vodovotz, Bartels and AnChapter 9: Computational Modeling of the Coagulation Response -Scott Diamond Part IV: Translational Modeling of Organ/Tissue Specific Inflammatory Disease Processes Chapter 10: Disorder of Localized Inflammation in Wound Healing -Stephen BadylakChapter11: Equation-based Models of Wound Healing and Collective Cell Migration -Julia Arciero and David SwigonChapter 12: Agent-based Models of Wound Healing -Yoram Vodovotz and Gary AnChapter 13: Tissue realistic translational modeling of gut inflammation -Chase Cockrell and Gary AnChapter 14: Data-DrivenModeling of Liver Injury, Inflammation, and Fibrosis -Ruben Zamora and Yoram VodovotzChapter 15: Computational Modeling of Tuberculosis -Denise Kirschner Part V: Future Perspectives: Translation to ImplementationChapter 16: "The Rationale and Implementation of Model-based Precision Medicine for Inflammatory Diseases"Gary An and Yoram Vodovotz
Описание: These volumes present the main classes of useful laboratory model systems used to study microbial ecosystems, with emphasis on the practical details for the use of each model.
Автор: Goldsmith Marian R., Wilkins Adam S. Название: Molecular Model Systems in the Lepidoptera ISBN: 0521402492 ISBN-13(EAN): 9780521402491 Издательство: Cambridge Academ Цена: 16632.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book deals with molecular-level research using Lepidoptera. Each chapter is a self-contained treatment of a broad subject area, providing sufficient information to give a sense of the principles and central questions associated with each topic. Comparisons with other systems are emphasized, particularly Drosophila.
Описание: Part I: OverviewChapter 1: "An Overview of the Translational Dilemma and the Need for Model-based Precision Medicine" Yoram Vodovotz and Gary An Part II: "Computational Modeling Methods and Biomedical Applications"Chapter 2: Translational Equation-based Modeling -Gilles ClermontChapter 3: Agent-based Modeling in Translational Systems Biology -Gary An Chapter 4: Integrating Data-driven and Mechanistic Modeling in Sepsis and Trauma -Yoram VodovotzChapter 5: Therapeutics as Control: Model-based approaches for control discovery -Chase Cockrell, Judy Day, Gary An Part III: Translational Modeling of Sepsis and TraumaChapter 6: Disorder of Systemic Inflammation in Sepsis and Trauma: A Systems Perspective -Tim Billiar Chapter 7: Multiscale Equation-based Models: Insights for Inflammation and Physiological Variability -Ioannis AndroulakisChapter 8: In silicoTrials and Personalized Therapy for Sepsis and Trauma -Vodovotz, Bartels and AnChapter 9: Computational Modeling of the Coagulation Response -Scott Diamond Part IV: Translational Modeling of Organ/Tissue Specific Inflammatory Disease Processes Chapter 10: Disorder of Localized Inflammation in Wound Healing -Stephen BadylakChapter11: Equation-based Models of Wound Healing and Collective Cell Migration -Julia Arciero and David SwigonChapter 12: Agent-based Models of Wound Healing -Yoram Vodovotz and Gary AnChapter 13: Tissue realistic translational modeling of gut inflammation -Chase Cockrell and Gary AnChapter 14: Data-DrivenModeling of Liver Injury, Inflammation, and Fibrosis -Ruben Zamora and Yoram VodovotzChapter 15: Computational Modeling of Tuberculosis -Denise Kirschner Part V: Future Perspectives: Translation to ImplementationChapter 16: "The Rationale and Implementation of Model-based Precision Medicine for Inflammatory Diseases"Gary An and Yoram Vodovotz
Автор: Seckbach, Joseph Название: Model Ecosystems in Extreme Environments ISBN: 0128127422 ISBN-13(EAN): 9780128127421 Издательство: Elsevier Science Рейтинг: Цена: 15831.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Model Ecosystems in Extreme Environments examines ecosystems at the most extreme habitats and their interaction with the environment, which is key to understanding the role and function of microorganisms in nature, and consequently the implications of life at local and global scales. It also highlights current topics in the field, such as biodiversity and the structure of microbial communities in extreme environments, the effects of extreme environmental conditions on microbial ecosystems, and ecological and evolutionary interactions in extreme environments, among many others. Model Ecosystems in Extreme Environments is a valuable text for an interdisciplinary audience, including faculty and students working with extremophiles and/or microbial ecology and researchers in a number of fields, including astrobiologists, biologists, evolutionary scientists, astronomers, geochemists, and oceanographers.
Explores in detail how microbial ecosystems thrive in extreme environments
Highlights the relevance of extremophiles as model ecosystems to the study of microbial ecology
Examines how extreme ecosystems could help our search for life on other planets
Автор: Kloc Название: Marine Organisms as Model Systems in Biology and Medicine ISBN: 3319924850 ISBN-13(EAN): 9783319924854 Издательство: Springer Рейтинг: Цена: 39130.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This book highlights the potential advantages of using marine invertebrates like tunicates, echinoderms, sponges and cephalopods as models in both biological and medical research. Bioactive compounds found in marine organisms possess antibacterial, antifungal, anti-diabetic and anti-inflammatory properties, and can affect the immune and nervous systems. Despite substantial research on the medicinal attributes of various marine invertebrates, they are still very much underrepresented in scientific literature: the majority of cell, developmental and evolutionary scientific journals only publish research conducted on a few well-known model systems like Drosophila melanogaster or Xenopus laevis.
Addressing that gap, this book introduces readers to new model organisms like starfish or nemertera. By showing their benefits with regard to regeneration, stem cell research and Evo-Devo, the authors provide a cross-sectional view encompassing various disciplines of biological research. As such, this book will not only appeal to scientists currently working on marine organisms, but will also inspire future generations to pursue research of their own.
Описание: The proprotein convertase Furin is a serine endoprotease which cleaves protein precursors carboxyterminal of basic residues in motifs such as Arg–X–X–Arg and Lys/Arg–Arg. Cleavage usually results in activation of the proprotein but can also inactivate or modify the activity. Therefore, it is not surprising that it plays a major role in many physiological processes and pathologies, including cancer. The other proprotein convertases belonging to the same family, PC1/3, PC2, PACE4, PC4, PC5/6, and PC7, cleave at similar cleavage sites and provide partial redundancy. To unravel the specific role of Furin in vivo, knockout mouse models have been generated. Furin null mice die between e10.5 and e11.5 due to severe ventral closure defects and the failure of the heart tube to fuse and undergo looping morphogenesis. Therefore, a conditional Furin knockout mouse was generated to investigate the role of Furin in specific organs, such as pancreas, liver, T-cells, endothelial cells, and salivary glands, resulting in a severe or mild phenotype depending on the organ investigated. Partial or complete ablation of the Fur gene in salivary gland tumors significantly delayed tumorigenesis in mice. Therefore, Furin inhibition might be considered as a possible therapeutic strategy to treat certain pathologies, such as cancer.
Автор: Wu-Min Deng Название: The Drosophila Model in Cancer ISBN: 3030236285 ISBN-13(EAN): 9783030236281 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume provides a series of review articles that capture the advances in using the fruit fly, Drosophila melanogaster, model system to address a wide range of cancer-related topics. Articles in this book provide case studies that shed light on the intricate cellular and molecular mechanisms underlying tumor formation and progression. Readers will discover the beauty of the fly model’s genetic simplicity and the vast arsenal of powerful genetic tools enabling its efficient and adaptable use. This model organism has provided a unique opportunity to address questions regarding cancer initiation and development that would be extremely challenging in other model systems. This book provides a useful resource for a researcher who wishes to learn about and apply the Drosophila model to tackle fundamental questions in cancer biology, and to find new ways to fight against this devastating disease.
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