Biomarkers in Clinical Drug Development, Bloom, John

Автор: Zhang, Lijuan
Название: Progress in Molecular Biology and Translational Science
ISBN: 0128177381 ISBN-13(EAN): 9780128177389
Издательство: Elsevier Science
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Цена: 20043.00 р.
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Glycans and Glycosaminoglycans as Clinical Biomarkers and Therapeutics - Part A, Volume 162 in the Progress in Molecular Biology and Translational Science series provides informative monographs on a variety of research topics related to Glycans and glycosaminoglycans as clinical biomarkers and therapeutics. Topics in this update include Glycan-based Biomarkers for Diagnosis of Cancers and Other Diseases: Past, Present and Future, Desialylation in Diseases and its Application in Diagnostic and Therapeutic Development, Proteoglycans as Miscommunication Biomarkers for Cancer Diagnosis, Fucosylation in Cancer Biology and Its Clinical Applications, Retrospective Analysis of Glycan-Related Biomarkers Based on Clinical Laboratory Data in Two Medical Centers, and many related topics.

Название: Novel cancer-related biomarkers: Novel cancer-related biomarkers
ISBN: 3110481537 ISBN-13(EAN): 9783110481532
Издательство: Walter de Gruyter
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Цена: 3710.00 р.
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Описание: Various KLK proteins and their encoding genes have attracted increased attention among scientists and clinicians worldwide since they represent very interesting and functionally distinct biomarkers, particularly, in cancer. This book reviews the role of kallikrein-related peptidases (KLKs) in a wide range of cancers, including lung, prostate, breast and ovarian cancer. It provides clinicians, physician scientists and researchers with a comprehensive overview on the clinical relevance of KLK expression in various malignancies.

Автор: Zhang, Lijuan
Название: Progress in Molecular Biology and Translational Science
ISBN: 0128177403 ISBN-13(EAN): 9780128177402
Издательство: Elsevier Science
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Цена: 20043.00 р.
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Описание:

Glycans and Glycosaminoglycans as Clinical Biomarkers and Therapeutics - Part B, Volume 163 in the Progress in Molecular Biology and Translational Science series, provides informative monographs on a variety of research topics related to Glycans and glycosaminoglycans as clinical biomarkers and therapeutics. Topics in this update include an Overview of Fugal Glycan-based Therapeutics, Heparin: An Essential Drug for Modern Medicine, Low Molecular Weight Heparins and Their Clinical Applications, The Clinical Use of Fondaparinux: A Synthetic Heparin Pentasaccharid, Heparinoids as Clinically Used Drugs, Marine Glycan-Derived Therapeutics in China, Efficacy of Heparinoid PSS in Treating Cardiovascular and other Diseases--30 Years Clinical Applications in China, and more.

Автор: Viktor Magdolen, Christian P. Sommerhoff, Hans Fritz, Manfred Schmitt
Название: Novel cancer-related biomarkers
ISBN: 3110303582 ISBN-13(EAN): 9783110303582
Издательство: Walter de Gruyter
Цена: 26024.00 р.
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Описание: Various KLK proteins and their encoding genes have attracted increased attention among scientists and clinicians worldwide since they represent very interesting and functionally distinct biomarkers, particularly, in cancer. This book reviews the role of kallikrein-related peptidases (KLKs) in a wide range of cancers, including lung, prostate, breast and ovarian cancer. It provides clinicians, physician scientists and researchers with a comprehensive overview on the clinical relevance of KLK expression in various malignancies.

Автор: Halim, Abdel
Название: Biomarkers, Diagnostics and Precision Medicine in the Drug Industry
ISBN: 0128161213 ISBN-13(EAN): 9780128161210
Издательство: Elsevier Science
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Цена: 19875.00 р.
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Описание:

The high failure rate in the pharmaceutical industry has positioned biomarkers and personalized medicine in the frontline as possible solutions. If executed right, biomarkers and companion diagnostics (CDx) can potentially help the drug industry enhance the probability of success, accelerating time to market, and, more importantly, benefit patients by supporting accurate diagnosis and selection of the most effective and least toxic therapies. Biomarkers, Diagnostics, and Precision Medicine in the Drug Industry aims to examine the challenges and limitations in biomarkers and laboratory tests. It also offers advice on best practices to ensure proper application of biomarkers and bridges the gap between diagnostic business development claims and real-life deliverables. The book covers biomarkers for different purposes, provides examples from different technologies which includes standard-of-care approved assays as well as for-investigational-use and for-research-use-only assays. It also includes new data for biomarkers in different therapeutic indications and offers case studies and practical examples. Biomarkers, Diagnostics, and Precision Medicine in the Drug Industry serves as a reference to drug developers, IVD providers, healthcare givers, academics, and researchers for best practices to help increase the probability of success.

Автор: Robert Perneczky
Название: Biomarkers for Alzheimer`s Disease Drug Development
ISBN: 1493992627 ISBN-13(EAN): 9781493992621
Издательство: Springer
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Цена: 11179.00 р.
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Описание: This volume aims to build a new generation of experts with a broader understanding of key topics in the Alzheimer’s disease field. Chapters guide readers through innovative approaches to the discovery of novel biomarkers in cerebrospinal fluid, innovation in blood-based biomarkers, a comprehensive overview of magnetic resonance imaging and molecular imaging approaches and their value for developing drugs for Alzheimer’s disease, cutting-edge developments in neuropathology and their relevance for Alzheimer’s disease trials, novel genomic strategies for biomarker development, and related topics including neuropsychological testing and advanced analytical methods.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Biomarkers for Alzheimer's Disease Drug Development aims to ensure successful results in the further study of this vital field.

Автор: Dasgupta, Amitava
Название: Therapeutic Drug Monitoring
ISBN: 0123854679 ISBN-13(EAN): 9780123854674
Издательство: Elsevier Science
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Цена: 21054.00 р.
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Описание: Features topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This title presents advanced techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs.

Автор: Perneczky
Название: Biomarkers for Alzheimer`s Disease Drug Development
ISBN: 1493977032 ISBN-13(EAN): 9781493977031
Издательство: Springer
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Цена: 11179.00 р.
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Описание:

PART I: The need for Alzheimer's Disease Biomarkers

20. Telomere length shortening in Alzheimer's disease - procedures for a causal investigation using single nucleotide polymorphisms in a Mendelian Randomization study
Yiqiang Zhan,

Автор: Lambert Holly
Название: Biomarkers in Drug Discovery and Disease Diagnosis
ISBN: 1632428350 ISBN-13(EAN): 9781632428356
Издательство: Неизвестно
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Цена: 23335.00 р.
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Автор: Burnett Ned
Название: Encyclopedia of Drug Discovery and Development: Volume II (Tools, Methods, Biomarkers and Drug Discovery)
ISBN: 1632421372 ISBN-13(EAN): 9781632421371
Издательство: Неизвестно
Цена: 23979.00 р.
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Автор: Thomas D`Hooghe
Название: Biomarkers for Endometriosis
ISBN: 3319598546 ISBN-13(EAN): 9783319598543
Издательство: Springer
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Цена: 19564.00 р.
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Описание: This would include nearly all cases of minimal-mild endometriosis, some cases of moderate-severe endometriosis without a clearly visible ovarian endometrioma and cases with pelvic adhesions and/or other pelvic pathology, who might benefit from surgery to improve pelvic pain and/or subfertility.

Автор: Guest Paul C.
Название: Studies on Biomarkers and New Targets in Aging Research in Iran: Focus on Turmeric and Curcumin
ISBN: 3030561526 ISBN-13(EAN): 9783030561529
Издательство: Springer
Цена: 27950.00 р.
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Описание:

1. Research in the Middle East into the Health Benefits of Curcumin

2. Turmeric and Curcumin: From Traditional to Modern Medicine

3. Targeting Nuclear Factor-kappa B signaling pathway by curcumin: implications for the treatment of multiple sclerosis

4. Carbon-based Nanomaterials and Curcumin: a Review of Biosensing Applications

5. Effects of Curcumin and its Analogues on Bacterial and Parasitic Infectious Diseases

6. Protective Effects of Curcumin on Endothelium: an Updated Review

7. The Effect of Curcumin Supplementation on Anthropometric Indices in Overweight and Obese Individuals: A Systematic Review of Randomized Controlled Trials

8. Effect of Curcumin on Glycemic Control in Patients with Type 2 Diabetes: A Systematic Review of Randomized Clinical Trials

9. Anti-diabetic Properties of Curcumin: Insights on New Mechanisms

10. The effect of Curcumin in improving Lipid Profile in Patients with Cardiovascular Risk Factors: a Systematic Review of Clinical Trials

11. The effects of curcumin in the treatment of gingivitis: A systematic review of clinical trials

12. Does Curcumin have an Anti-caries Effect? A Systematic Review of In vitro Studies

13. The clinical use of curcumin for the treatment of recurrent aphthous stomatitis: A systematic review of clinical trials

14. Antibacterial Activity of Curcumin against Periodontal Pathogens: A Systematic Review

15. The Clinical use of Curcumin for the Treatment of Rheumatoid Arthritis: A Systematic Review of Clinical Trials

16. A Systematic Review of the Clinical use of Curcumin for Treatment of Osteoarthritis

17. Effects of Curcumin on Depression and Anxiety: A Narrative Review of the Recent Clinical Data

18. A Systematic Review of the Clinical use of Curcumin for Management of Gastrointestinal Diseases

19. The use of Curcumin for the Treatment of Renal Disorders: a Systematic Review of Randomized Controlled Trials

20. Curcumin for the Treatment of Prostate Diseases: a Systematic Review of Controlled Clinical Trials

21. Curcumin: a Review of its Effects on Epilepsy

Index