Biomarkers for Alzheimer`s Disease Drug Development, Robert Perneczky

Автор: Perneczky
Название: Biomarkers for Alzheimer`s Disease Drug Development
ISBN: 1493977032 ISBN-13(EAN): 9781493977031
Издательство: Springer
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PART I: The need for Alzheimer's Disease Biomarkers

20. Telomere length shortening in Alzheimer's disease - procedures for a causal investigation using single nucleotide polymorphisms in a Mendelian Randomization study
Yiqiang Zhan,

Автор: Lambert Holly
Название: Biomarkers in Drug Discovery and Disease Diagnosis
ISBN: 1632428350 ISBN-13(EAN): 9781632428356
Издательство: Неизвестно
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Автор: Nikki P. Lee; C.Y. Cheng; John M. Luk
Название: New Advances on Disease Biomarkers and Molecular Targets in Biomedicine
ISBN: 1627039015 ISBN-13(EAN): 9781627039017
Издательство: Springer
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Цена: 22201.00 р.
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Описание: This book describes current research on disease biomarkers, including oncofetal molecules in cancer prediction and treatment, evolving development in cancer biology at the cellular and molecular levels and understanding of new classes of molecules in diseases.

Автор: Yihong Yao
Название: Genomic Biomarkers for Pharmaceutical Development,
ISBN: 0123973368 ISBN-13(EAN): 9780123973368
Издательство: Elsevier Science
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Описание: Genomic Biomarkers for Pharmaceutical Development: Advancing Personalized Health Care provides an in-depth review of the state of translational science across all stages of pharmaceutical development with a special focus on personalized health care. This book provides a complete picture of biomarker development and validation in a pharmaceutical setting while addressing the inherent challenges of targeting the appropriate indications, biomarker robustness, regulatory hurdles, commercialization and much more. It features case studies devoted to the applications of pharmacogenomics, toxicogenomics, and other genetic technologies as they support drug discovery and development. . With chapters written by international authorities in industry and academia, this work is a truly unique presentation of the thoughts and approaches that lead to the development of personalized medicine. Intended for all those involved in clinical translational research, this book is the ideal resource for scientists searching for the applications, strategies and successful approaches of translational science in pharmaceutical development.

Автор: Robert Perneczky
Название: Biomarkers for Preclinical Alzheimer`s Disease
ISBN: 1493992554 ISBN-13(EAN): 9781493992553
Издательство: Springer
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Цена: 13275.00 р.
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Описание: This volume discusses the importance of imaging, fluid, and genetic biomarkers in detecting the earliest pre-symptomatic stages of Alzheimer’s disease (AD). The chapters in this book are separated into five parts. Part one explores the reasons why we need improved approaches for early detection and diagnosis of AD. Part two describes clinical and research techniques for preclinical AD diagnosis. Part three looks at the current methods in use to diagnose AD and how they can also be used for early detection in healthy older individuals. Parts four and five talk about technological advancements in AD diagnosis and ethical considerations in AD research. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Comprehensive and cutting-edge, Biomarkers for Preclinical Alzheimer’s Disease is a valuable resource for individuals interested in the use of biomarker strategies to improve early AD detection. This book will be of great interest to researchers and clinicians from both academia and industry.”

Автор: Perneczky
Название: Biomarkers for Preclinical Alzheimer`s Disease
ISBN: 1493976737 ISBN-13(EAN): 9781493976737
Издательство: Springer
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Цена: 9781.00 р.
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Описание: This volume discusses the importance of imaging, fluid, and genetic biomarkers in detecting the earliest pre-symptomatic stages of Alzheimer`s disease (AD). Parts four and five talk about technological advancements in AD diagnosis and ethical considerations in AD research.

Название: Novel Biomarkers for Heart Disease
ISBN: 3039438832 ISBN-13(EAN): 9783039438839
Издательство: Неизвестно
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Цена: 14419.00 р.
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Cardiac biomarkers such as troponins and natiuretic peptides have made a great impact on clinical decision making as well as improving our understanding of molecular mechanisms of different disease conditions. However, the biomarkers that are currently in use do not reflect all the multiple disease pathways that are involved in a broad spectrum of cardiac disease conditions ranging from acute coronary syndrome, to heart failure (and heart failure with preserved ejection fraction, HFpEF), to pulmonary hypertension or arrhythmias. In this Special Issue, we will provide an overview of the current developments in the field of biomarker research, beginning with research on molecular pathways and cellular communication (e.g., microRNA) up to the clinical use of biomarkers.

Автор: Halim, Abdel
Название: Biomarkers, Diagnostics and Precision Medicine in the Drug Industry
ISBN: 0128161213 ISBN-13(EAN): 9780128161210
Издательство: Elsevier Science
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The high failure rate in the pharmaceutical industry has positioned biomarkers and personalized medicine in the frontline as possible solutions. If executed right, biomarkers and companion diagnostics (CDx) can potentially help the drug industry enhance the probability of success, accelerating time to market, and, more importantly, benefit patients by supporting accurate diagnosis and selection of the most effective and least toxic therapies. Biomarkers, Diagnostics, and Precision Medicine in the Drug Industry aims to examine the challenges and limitations in biomarkers and laboratory tests. It also offers advice on best practices to ensure proper application of biomarkers and bridges the gap between diagnostic business development claims and real-life deliverables. The book covers biomarkers for different purposes, provides examples from different technologies which includes standard-of-care approved assays as well as for-investigational-use and for-research-use-only assays. It also includes new data for biomarkers in different therapeutic indications and offers case studies and practical examples. Biomarkers, Diagnostics, and Precision Medicine in the Drug Industry serves as a reference to drug developers, IVD providers, healthcare givers, academics, and researchers for best practices to help increase the probability of success.

Автор: Aziz Syed a., Mehta Rekha
Название: Technical Aspects of Toxicological Immunohistochemistry: System Specific Biomarkers
ISBN: 1493979655 ISBN-13(EAN): 9781493979653
Издательство: Springer
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Цена: 13974.00 р.
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Описание: This authoritative volume examines immunohistochemical methods aimed at investigating the toxicologic pathology of rodent, non-human primate and aquatic animal tissues.

Название: Toxicologic Biomarkers
ISBN: 0367453703 ISBN-13(EAN): 9780367453701
Издательство: Taylor&Francis
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Описание: Responding to the explosion of advances in the use of biomarkers to efficiently, rapidly, and economically evaluate the health effects of chemical entities, this authoritative reference provides a detailed overview of the theory, development, and practical application of biomarkers in the toxicological, environmental, forensic, and pharmaceutical s

Автор: Martin Ingelsson; Lars Lannfelt
Название: Immunotherapy and Biomarkers in Neurodegenerative Disorders
ISBN: 1493980785 ISBN-13(EAN): 9781493980789
Издательство: Springer
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Цена: 15372.00 р.
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Описание: With a focus on Alzheimer`s disease, the firstsections of the book examine immunotherapeutic approaches for theaforementioned disease as well as for Parkinson`s disease and Huntington`s disease,amongst others.

Автор: Roberto Scatena
Название: Advances in Cancer Biomarkers
ISBN: 9402404201 ISBN-13(EAN): 9789402404203
Издательство: Springer
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Цена: 23508.00 р.
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Описание:

Prelims.- I Generality.- II Tumor markers-a critical revision.- Enzymes.- Hormones.- Oncofetal proteins.- Cytokeratins.- Carbohydrate markers.- Blood group antigens.- Genetic markers.- Various protein markers.- III Perspectives.- The role of Circulating tumor Cells as tumor markers.- Index.