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Biomarkers for Preclinical Alzheimer`s Disease, Robert Perneczky
Robert Perneczky Biomarkers for Preclinical Alzheimer`s Disease 9781493992553

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Автор: Robert Perneczky
Название:  Biomarkers for Preclinical Alzheimer`s Disease
ISBN: 9781493992553
Издательство: Springer
Классификация:
Болезнь Альцгеймера и дименция

Науки о жизни (медико-биологические): общие вопросы

Нейронауки

ISBN-10: 1493992554
Обложка/Формат: Soft cover
Страницы: 272
Вес: 0.55 кг.
Дата издания: 2018
Серия: Neuromethods
Язык: English
Издание: Softcover reprint of
Иллюстрации: 33 tables, color; 33 illustrations, color; 6 illustrations, black and white; xiii, 272 p. 39 illus., 33 illus. in color.
Размер: Book (Paperback Initiative)
Читательская аудитория: Professional & vocational
Основная тема: Biomedicine
Ссылка на Издательство: Link
Рейтинг:
Поставляется из: Германии
Описание: This volume discusses the importance of imaging, fluid, and genetic biomarkers in detecting the earliest pre-symptomatic stages of Alzheimer’s disease (AD). The chapters in this book are separated into five parts. Part one explores the reasons why we need improved approaches for early detection and diagnosis of AD. Part two describes clinical and research techniques for preclinical AD diagnosis. Part three looks at the current methods in use to diagnose AD and how they can also be used for early detection in healthy older individuals. Parts four and five talk about technological advancements in AD diagnosis and ethical considerations in AD research. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Comprehensive and cutting-edge, Biomarkers for Preclinical Alzheimer’s Disease is a valuable resource for individuals interested in the use of biomarker strategies to improve early AD detection. This book will be of great interest to researchers and clinicians from both academia and industry.”
Дополнительное описание:
Worldwide Economic Costs and Societal Burden of Dementia.- Epidemiology and Risk Factors of Alzheimer’s Disease: A Focus on Diet.- The Dimensional Structure of Subjective Cognitive Decline.- Deriving and Testing the Validity of Cognitive-Reserve Cand



Biomarkers for Preclinical Alzheimer`s Disease

Автор: Perneczky
Название: Biomarkers for Preclinical Alzheimer`s Disease
ISBN: 1493976737 ISBN-13(EAN): 9781493976737
Издательство: Springer
Рейтинг:
Цена: 9781.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This volume discusses the importance of imaging, fluid, and genetic biomarkers in detecting the earliest pre-symptomatic stages of Alzheimer`s disease (AD). Parts four and five talk about technological advancements in AD diagnosis and ethical considerations in AD research.

Biomarkers for Alzheimer`s Disease Drug Development

Автор: Perneczky
Название: Biomarkers for Alzheimer`s Disease Drug Development
ISBN: 1493977032 ISBN-13(EAN): 9781493977031
Издательство: Springer
Рейтинг:
Цена: 11179.00 р.
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Описание:

PART I: The need for Alzheimer's Disease Biomarkers

1. Epidemiology of Dementia: The Burden on Society, the Challenges for Research

Frank J. Wolters and M. Arfan Ikram

2. Population-based Approaches to Alzheimer's Disease Prevention

Robert Perneczky

3. Systems Biology Methods for Alzheimer's Disease Research towards Molecular Signatures, Subtypes and Stages and Precision Medicine. Application in Cohort Studies and Trials

Juan I. Castrillo, Simone Lista, Harald Hampel, and Craig W. Ritchie

PART II: Innovative Approaches to Cerebrospinal Fluid Biomarker Discovery

4. CSF Lipidomics Analysis: High-Resolution Mass Spectrometry Analytical Platform

Paul L. Wood and Randall L. Woltjer

5. CSF N-glycomics using MALDI MS Techniques in Alzheimer's Disease

Angelo Palmigiano, Angela Messina, Rosaria Ornella Bua, Rita Barone, Luisa Sturiale, Mario Zappia, and Domenico Garozzo

6. MicroRNA Profiling of Alzheimer's Disease Cerebrospinal Fluid Johannes Denk and Holger Jahn

Part III: Novel Blood-based Biomarkers

7. Validation of a Chemiluminescence Immunoassay for Measuring Amyloid-β in Human Blood Plasma

Jonathan Vogelgsang, Jens Wiltfang, and Hans-W. Klafki

8. Mass Spectrometry-based Metabolomic Multiplatform for Alzheimer's Disease Research

Raъl Gonzбlez-Domнnguez, Бlvaro Gonzбlez-Domнnguez, Ana Sayago, and Бngeles Fernбndez-Recamales

9. Blood-based Biomarker Screening with Agnostic Biological Definitions for an Accurate Diagnosis within the Dimensional Spectrum of Neurodegenerative Diseases

Filippo Baldacci, Simone Lista, Sid E. O'Bryant, Roberto Ceravolo, Nicola Toschi, and Harald Hampel,

Part IV: Magnetic Resonance Imaging Methods

10. Functional Magnetic Resonance Imaging in Alzheimer' Disease Drug Development

Stefan Holiga, Ahmed Abdulkadir, Stefan Klцppel, and Juergen Dukart

11. Neuroimaging Methods for MRI Analysis in CSF Biomarkers Studies

Carles Falcon, Grйgory Operto, Josй Luis Molinuevo, and Juan Domingo Gispert

12. Hybrid PET-MRI in Alzheimer's Disease Research

Ismini C. Mainta, Maria I. Vargas, Sara Trombella, Giovanni B. Frisoni, Paul G. Unschuld, Valentina Garibotto

Part V: Molecular Imaging Approaches

13. Amyloid PET Imaging: Standardization and Integration with Other Alzheimer Disease Biomarkers

Silvia Morbelli and Matteo Bauckneht

14. The use of 18F-FDG PET in the Diagnostic Workup of Alzheimer's Dementia

Marion M. Ortner

15. Quantification of Tau Load in Alzheimer's Disease Clinical Trials Using Positron Emission Tomography

Tessa Timmers, Bart N.M. van Berckel, Adriaan Lammertsma, and Rik Ossenkoppele

16. Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach

Elena Rodriguez-Vieitez and Agneta Nordberg

Part VI: Neuropathology

17. Unbiased Lipidomics and Metabolomics of Human Brain Samples

Giuseppe Astarita, Matteo Stocchero, and Giuseppe Paglia

18. Neuropathological Assessment as an Endpoint in Clinical Trial Design

Steve Gentleman and Alan King Lun Liu

Part VII Genomic Methods

19. Analysis of micro-RNA Expression by qPCR on a Microfluidics Platform for Alzheimer's Disease Biomarker Discovery

Petros Takousis

20. Telomere length shortening in Alzheimer's disease - procedures for a causal investigation using single nucleotide polymorphisms in a Mendelian Randomization study
Yiqiang Zhan,

Atlas of Biomarkers for Alzheimer`s Disease

Автор: Manuel Men?ndez Gonz?lez
Название: Atlas of Biomarkers for Alzheimer`s Disease
ISBN: 3319079883 ISBN-13(EAN): 9783319079882
Издательство: Springer
Рейтинг:
Цена: 13974.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: A lot of research on biomarkers for Alzheimer is being done in the last few decades. The aim of these studies is to find some method to ease the diagnosis of Alzheimers as early as possible. Such methods are a range of blood or CSF tests on one hand and several types of neuroimaging scans on the other. Many of the images coming both from laboratory and neuroimaging are very visual and illustrative. These images, accompanied by a short description, can perfectly explain the main results and usefulness of every biomarker. The objective of this book would be to summarize the most important studies made in this field. Few publications have systematically compiled results on this topic and only one as an atlas. Readers would be interested in this publication because it allows reviewing the current status of research by handily visualizing the results.

Biomarkers in Alzheimer`s Disease

Автор: Khan, Tapan
Название: Biomarkers in Alzheimer`s Disease
ISBN: 0128048328 ISBN-13(EAN): 9780128048320
Издательство: Elsevier Science
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Цена: 11620.00 р.
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Описание:

Biomarkers in Alzheimer's Disease provides a comprehensive overview of all modalities of Alzheimer's disease biomarkers, including neuroimaging, cerebrospinal fluid, genomic, and peripheral systems. Each chapter integrates molecular/cellular abnormality due to Alzheimer's disease and technological advancement of biomarkers techniques.

The book is ideal for clinical neuroscience and molecular/cellular neuroscience researchers, psychiatrists, and allied healthcare practitioners involved in the diagnosis and management of patients with cognitive impairment and Alzheimer's disease, and for differential diagnosis of Alzheimer's disease with other non-Alzheimer's dementia.
Structural Bioinformatics: Applications in Preclinical Drug Discovery Process

Автор: C. Gopi Mohan
Название: Structural Bioinformatics: Applications in Preclinical Drug Discovery Process
ISBN: 3030052818 ISBN-13(EAN): 9783030052812
Издательство: Springer
Рейтинг:
Цена: 23757.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание:

This book reviews the advances and challenges of structure-based drug design in the preclinical drug discovery process, addressing various diseases, including malaria, tuberculosis and cancer. Written by internationally recognized researchers, this edited book discusses how the application of the various in-silico techniques, such as molecular docking, virtual screening, pharmacophore modeling, molecular dynamics simulations, and residue interaction networks offers insights into pharmacologically active novel molecular entities. It presents a clear concept of the molecular mechanism of different drug targets and explores methods to help understand drug resistance. In addition, it includes chapters dedicated to natural-product- derived medicines, combinatorial drug discovery, the CryoEM technique for structure-based drug design and big data in drug discovery.
The book offers an invaluable resource for graduate and postgraduate students, as well as for researchers in academic and industrial laboratories working in the areas of chemoinformatics, medicinal and pharmaceutical chemistry and pharmacoinformatics.
Biomarkers in Brain Disease

Автор: Lovestone
Название: Biomarkers in Brain Disease
ISBN: 1573317721 ISBN-13(EAN): 9781573317726
Издательство: Wiley
Рейтинг:
Цена: 15484.00 р.
Наличие на складе: Поставка под заказ.

Описание: Advances in biomarker development are revolutionizing the way we study, diagnose and treat disease. However, progress in the development and use of biomarkers for diseases of the central nervous system has been limited by a number of difficulties -- including the inherent barriers associated with studying the brain.

Preclinical Research In Down Syndrome: Insights For Pathophysiology And Treatments,251

Автор: Dierssen, Mara
Название: Preclinical Research In Down Syndrome: Insights For Pathophysiology And Treatments,251
ISBN: 0444642560 ISBN-13(EAN): 9780444642561
Издательство: Elsevier Science
Рейтинг:
Цена: 33678.00 р.
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Описание:

Preclinical Research in Down Syndrome: From Bench to Bedside, Volume 251, the latest release in the Progress in Brain Research series, highlights new advances in the field. Chapters in this updated release include Exploring genetic and epigenetic mechanisms underlying cognitive deficits in Dow syndrome, The trisomy paradox: gene expression dysregulation domains, the Influence of allelic differences in mouse models of Down syndrome, Modelling Down syndrome in cells: From stem cells to organoids, Modelling Down syndrome in animals from the early stage to the new generation of models, Mapping behavioral landscapes in Down syndrome animal models, and more.

Biomarkers Of Postpartum Psychiatric Disorders

Автор: Payne, Jennifer L.
Название: Biomarkers Of Postpartum Psychiatric Disorders
ISBN: 0128155086 ISBN-13(EAN): 9780128155080
Издательство: Elsevier Science
Рейтинг:
Цена: 19875.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание:

Biomarkers of Postpartum Psychiatric Disorders provides an up-to-date reference on the current research relating to biomarkers in psychiatric disorders, including major depressive disorder, OCD and bipolar disorder in the immediate postpartum time-period. It is the only reference on the market that synthesizes and interprets available data and reviews clinical phenotypes. Topics cover hormonal contributions, immunology, epigenetics and neuroimaging. While the risk of psychiatric illness during pregnancy appears to be equivalent to the risk at any other time in a woman's life, the risk in the immediate postpartum time period is dramatically increased, hence the importance of the discussions in this title.

Genomic Biomarkers for Pharmaceutical Development,

Автор: Yihong Yao
Название: Genomic Biomarkers for Pharmaceutical Development,
ISBN: 0123973368 ISBN-13(EAN): 9780123973368
Издательство: Elsevier Science
Рейтинг:
Цена: 11193.00 р.
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Описание: Genomic Biomarkers for Pharmaceutical Development: Advancing Personalized Health Care provides an in-depth review of the state of translational science across all stages of pharmaceutical development with a special focus on personalized health care. This book provides a complete picture of biomarker development and validation in a pharmaceutical setting while addressing the inherent challenges of targeting the appropriate indications, biomarker robustness, regulatory hurdles, commercialization and much more. It features case studies devoted to the applications of pharmacogenomics, toxicogenomics, and other genetic technologies as they support drug discovery and development. . With chapters written by international authorities in industry and academia, this work is a truly unique presentation of the thoughts and approaches that lead to the development of personalized medicine. Intended for all those involved in clinical translational research, this book is the ideal resource for scientists searching for the applications, strategies and successful approaches of translational science in pharmaceutical development.

Biomarkers in psychiatry

Название: Biomarkers in psychiatry
ISBN: 331999641X ISBN-13(EAN): 9783319996417
Издательство: Springer
Рейтинг:
Цена: 23757.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This volume addresses one of the Holy Grails in Psychiatry, namely the evidence for and potential to adopt ‘Biomarkers’ for prevention, diagnosis, and treatment responses in mental health conditions. It meshes together state of the art research from international renowned pre-clinical and clinical scientists to illustrate how the fields of anxiety disorders, depression, psychotic disorders, and autism spectrum disorder have advanced in recent years.


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