In Vitro Bioassay Techniques for Anticancer Drug Discovery and Development, Sunil, Dhanya
Автор: Teicher Название: Anticancer Drug Development Guide. 2ed.2004 ISBN: 1588292282 ISBN-13(EAN): 9781588292285 Издательство: Springer Рейтинг: Цена: 34799.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This thoroughly updated and expanded second edition of Beverly Teicher's widely used classic survey provides a step-by-step guide to anticancer drug development from initial design through FDA approval. The authors have included new material on the use of high throughput screening in industry, on specialized in vitro/in vivo procedures employed by the National Cancer Institute (NCI) in preclinical drug evaluations, and on nonclinical testing to support both human clinical trials, as well as trials of biologic oncology products. The chapters on phase I, II, and III clinical trials and on novel phase II clinical trial designs for targeted therapies have been significantly updated, along with those on cancer drug development in Europe, working with the NCI, and the FDA's role in cancer drug development and setting requirements for approval.
Автор: Atta-ur-Rahman Название: Bioassay Techniques for Drug Development ISBN: 9058230511 ISBN-13(EAN): 9789058230515 Издательство: Taylor&Francis Рейтинг: Цена: 26796.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Beverly A. Teicher Название: Anticancer Drug Development Guide ISBN: 1461581540 ISBN-13(EAN): 9781461581543 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Experienced cancer researchers from pharmaceutical companies, government laboratories, and academia comprehensively review and describe the arduous process of cancer drug discovery and approval.
Автор: Elizabeth Garrett-Mayer; Manuel Hidalgo; S. Gail E Название: Principles of Anticancer Drug Development ISBN: 1461427916 ISBN-13(EAN): 9781461427919 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This is a practical guide to the design, conduction, analysis and reporting of clinical trials with anticancer drugs. It includes coverage of basic biostatistics for the clinical trialist, and fundamental concepts in clinical pharmacology.
Автор: L. Harivardhan Reddy; Patrick Couvreur Название: Macromolecular Anticancer Therapeutics ISBN: 1461424925 ISBN-13(EAN): 9781461424925 Издательство: Springer Рейтинг: Цена: 36570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book details the macromolecular therapeutics for cancer therapy. It also covers the classification of these anticancer drugs based on therapeutic targets and elaborates on different classes of anticancer therapeutics.
Автор: Beverly A. Teicher; Paul A. Andrews Название: Anticancer Drug Development Guide ISBN: 146849841X ISBN-13(EAN): 9781468498417 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Since the earliest widely used in vivo drug screening models were the murine L 1210 and P388 leukemias, the community came to assume that these murine tumor models were appropriate to the discovery of "antileukemia" agents, but that other tumor models would be needed to discover drugs active against solid tumors.
Автор: L. Harivardhan Reddy; Patrick Couvreur Название: Macromolecular Anticancer Therapeutics ISBN: 1441905065 ISBN-13(EAN): 9781441905062 Издательство: Springer Рейтинг: Цена: 36570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Cancer treatment using Macromolecular therapeutics has considerably improved the survival benefit for the patients. This book assembles various types and aspects of macromolecular anticancer therapeutics for cancer therapy and conveys the importance of this interdisciplinary field.
Автор: Lars Bohlin; Jan G. Bruhn Название: Bioassay Methods in Natural Product Research and Drug Development ISBN: 9401060193 ISBN-13(EAN): 9789401060196 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Bioassay Methods in Natural Product Research and Drug Development contains the proceedings from the Phytochemical Society of Europe`s very successful symposium on this topic, held August 24-27, 1997 in Uppsala, Sweden.
Автор: Robert F. Ozols Название: Molecular and Clinical Advances in Anticancer Drug Resistance ISBN: 0792312120 ISBN-13(EAN): 9780792312123 Издательство: Springer Рейтинг: Цена: 37594.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The importance of drug resistance in cancer chemotherapy cannot be over- stated. The 500,000 patients who die every year from cancer in the United States have, in most cases, been treated with chemotherapy. Many of these patients responded initially to chemotherapy, but death resulted from the development of drug-resistant tumors. In the first volume in the series. Drug Resistance in Chemotherapy the results of comprehensive laboratory studies aimed at understanding the mechanisms for resistance to individual agents and to the development of broad cross-resistance were described. In the past 2 years there has been substantial progress in understanding the molecular biology associated with these mechanisms of drug resistance. For the first time we are starting to understand which mechanisms are playing an im- portant role in human tumors, and even more importantly, clinical trials have recently been initiated in an effort to reverse specific forms of drug resistance. The purpose of this volume is to describe the new advances, both at the molecular level and in the clinic regarding mechanisms of drug resistance and potential ways this resistance can be circumvented. This volume is focused upon mechanisms of resistance associated with two major classes of anticancer drugs: alkylating agents (including cisplatin) and the natural products (e. g., adriamycin and vinblastine). The first section of the book describes new insights into the genetic mechanisms associated with drug resistance.
Автор: Madkour, Loutfy H. Название: Nucleic Acids As Gene Anticancer Drug Delivery Therapy ISBN: 0128197773 ISBN-13(EAN): 9780128197776 Издательство: Elsevier Science Рейтинг: Цена: 26107.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research.
Автор: Benjamin Winograd; Michael Peckham; Herbert M. Pin Название: Human Tumour Xenografts in Anticancer Drug Development ISBN: 3642732542 ISBN-13(EAN): 9783642732546 Издательство: Springer Рейтинг: Цена: 19591.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Seminar on Human Tumour Xenografts 1986, Milan, Italy. European School of Oncology
Описание: This thesis describes the authors’ pioneering efforts in the conceptualization and implementation of combined platinum-based immuno-chemotherapeutics, which represent a significant paradigm shift from the conventional approach of directly targeting cancer. The work described has opened up a rich and largely unexplored area for platinum-based drug design, and ultimately paves the way for superior immuno-chemotherapeutics with better clinical outcome for patients. Historically, the contribution of the immune system to chemotherapy outcomes has been neglected, as anticancer drugs were believed to be immunosuppressive. However, this has been challenged by contemporary evidence suggesting that many chemotherapeutics, including platinum-based agents, stimulate the innate and/or adaptive immune system and that these “secret allies” contribute tangibly to clinical outcomes. A multi-pronged immuno-chemotherapeutic approach not only shrinks tumors, but more importantly, reactivate dormant immune responses to malignancies, eliminating residual cancer cells.
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