Автор: Blandina Patrizio, Passani Maria Beatrice Название: Histamine Receptors: Preclinical and Clinical Aspects ISBN: 3319820745 ISBN-13(EAN): 9783319820743 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A comprehensive and detailed overview of the current state of preclinical research on histamine and histamine receptors.
Автор: Yuichi Hattori; Roland Seifert Название: Histamine and Histamine Receptors in Health and Disease ISBN: 3319863444 ISBN-13(EAN): 9783319863443 Издательство: Springer Рейтинг: Цена: 30606.00 р. Наличие на складе: Поставка под заказ.
Автор: Ekaterini Tiligada; Madeleine Ennis Название: Histamine Receptors as Drug Targets ISBN: 1493968416 ISBN-13(EAN): 9781493968411 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
1. Methodologies to Identify and Analyze Genetic Polymorphisms for Human Histamine Receptors
Stephany Micallef and Astrid Sasse
2. Development, Characterization, and Validation of Anti-Human H3 Receptor Isoform-Specific Antibodies
Fiona C. Shenton, Natasha Lethbridge, and Paul L. Chazot
3. Approaches to Recombinant Histamine H3/H4 Receptor Expression in Mammalian Cells
Tadeusz Karcz, Urszula Cichoń, and Katarzyna Kiec-Kononowicz
4. Histamine H2 Receptor Biased Signaling Methods
Natalia Fernбndez, Carina Shayo, Carlos Davio, and Federico Monczor
5. Ligand-Binding Kinetics on Histamine Receptors
Reggie Bosma, Tamara A.M. Mocking, Rob Leurs, and Henry F. Vischer
6. Methods to Study the Molecular Pharmacology of the Histamine H4 Receptor
Elйonore W.E. Verweij, Rob Leurs, and Henry F. Vischer
7. Chemiluminescence: A Sensitive Method for Detecting the Effects of Histamine Receptor Agonists/Antagonists on Neutrophil Oxidative Burst
Ondřej Vasнček, Tomбs Perečko, Viera Jančinovб, Silvia Pazourekovб, Radomнr Nosбľ, and Milan Čнz
8. Techniques Used in Pharmacological Evaluation of Histamine H4 Receptor Function on Native Human Eosinophils
Marek Grosicki and Katarzyna Kiec-Kononowicz
9. Assessment of the Efficacy of Histamine Receptor Antagonists in Murine Models of Atopic Dermatitis
Kristine Ro bach, Hanna Kцchling, Tomoki Fukuyama, Jenny Wilzopolski, Manfred Kietzmann, and Wolfgang Bдumer
10. Methodological Approaches to Study Histamine Pharmacology in the Kidney: From Cell Culture and Cell Imaging to Functional Assays and Electron Microscopy
Alessandro Pini, Eleonora Veglia, Cristina Grange, and Arianna Carolina Rosa
11. Histamine and the Kidney: In VivoAnimal Models
Alessandro Pini, Eleonora Veglia, and Arianna Carolina Rosa
12. Methodological Approaches to Investigate the Effects of Histamine Receptor Targeting Compounds in Preclinical Models of Breast Cancer
Diego J. Martinel Lamas, Melisa B. Nicoud, Helena Sterle, Graciela P. Cricco, Gabriela A. Martin, Graciela A. Cremaschi, Hubert G. Schwelberger, Elena S. Rivera, and Vanina A Medina
13. Evaluation of Histidine Decarboxylase (HDC) Activity and Human Histamine Receptor 3 (H3R) and HDC mRNA Levels
Carlos Acosta-Andrade, Josй L Urdiales, Ignacio Fajardo, and Francisca Sбnchez-Jimйnez
14. Cerebrospinal Fluid Markers in Neuroinflammation: The Paradigm of Optic Neuritis
Dimitrios P. Besinis and Maria C. Anagnostouli
Название: Histamine receptors as drug targets ISBN: 1493983156 ISBN-13(EAN): 9781493983155 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
1. Methodologies to Identify and Analyze Genetic Polymorphisms for Human Histamine Receptors
Stephany Micallef and Astrid Sasse
2. Development, Characterization, and Validation of Anti-Human H3 Receptor Isoform-Specific Antibodies
Fiona C. Shenton, Natasha Lethbridge, and Paul L. Chazot
3. Approaches to Recombinant Histamine H3/H4 Receptor Expression in Mammalian Cells
Tadeusz Karcz, Urszula Cichoń, and Katarzyna Kiec-Kononowicz
4. Histamine H2 Receptor Biased Signaling Methods
Natalia Fernбndez, Carina Shayo, Carlos Davio, and Federico Monczor
5. Ligand-Binding Kinetics on Histamine Receptors
Reggie Bosma, Tamara A.M. Mocking, Rob Leurs, and Henry F. Vischer
6. Methods to Study the Molecular Pharmacology of the Histamine H4 Receptor
Elйonore W.E. Verweij, Rob Leurs, and Henry F. Vischer
7. Chemiluminescence: A Sensitive Method for Detecting the Effects of Histamine Receptor Agonists/Antagonists on Neutrophil Oxidative Burst
Ondřej Vasнček, Tomбs Perečko, Viera Jančinovб, Silvia Pazourekovб, Radomнr Nosбľ, and Milan Čнz
8. Techniques Used in Pharmacological Evaluation of Histamine H4 Receptor Function on Native Human Eosinophils
Marek Grosicki and Katarzyna Kiec-Kononowicz
9. Assessment of the Efficacy of Histamine Receptor Antagonists in Murine Models of Atopic Dermatitis
Kristine Ro bach, Hanna Kцchling, Tomoki Fukuyama, Jenny Wilzopolski, Manfred Kietzmann, and Wolfgang Bдumer
10. Methodological Approaches to Study Histamine Pharmacology in the Kidney: From Cell Culture and Cell Imaging to Functional Assays and Electron Microscopy
Alessandro Pini, Eleonora Veglia, Cristina Grange, and Arianna Carolina Rosa
11. Histamine and the Kidney: In VivoAnimal Models
Alessandro Pini, Eleonora Veglia, and Arianna Carolina Rosa
12. Methodological Approaches to Investigate the Effects of Histamine Receptor Targeting Compounds in Preclinical Models of Breast Cancer
Diego J. Martinel Lamas, Melisa B. Nicoud, Helena Sterle, Graciela P. Cricco, Gabriela A. Martin, Graciela A. Cremaschi, Hubert G. Schwelberger, Elena S. Rivera, and Vanina A Medina
13. Evaluation of Histidine Decarboxylase (HDC) Activity and Human Histamine Receptor 3 (H3R) and HDC mRNA Levels
Carlos Acosta-Andrade, Josй L Urdiales, Ignacio Fajardo, and Francisca Sбnchez-Jimйnez
14. Cerebrospinal Fluid Markers in Neuroinflammation: The Paradigm of Optic Neuritis
Dimitrios P. Besinis and Maria C. Anagnostouli
Автор: Blandina Название: Histamine Receptors ISBN: 3319403060 ISBN-13(EAN): 9783319403069 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A comprehensive and detailed overview of the current state of preclinical research on histamine and histamine receptors. Part of the book focuses on novel approaches to the study of histamine receptors such as polymorphism, genetic linkage, and computational analysis, and on the use of new histaminergic ligands in diseases such as asthma and dermatitis. Several chapters will be devoted to the role of histamine in the control of homeostatic and behavioral responses such as the sleep-wake cycle, regulation of the blood brain barrier, food intake, alertness, itch, and memory formation and consolidation.
Автор: Yanai Название: The Functional Roles of Histamine Receptors ISBN: 3031169964 ISBN-13(EAN): 9783031169960 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Research in the field of histamine receptors over the past 100 years went hand-in-hand with the development of modern pharmacology. Advances in histamine research led by outstanding scientists was so incisive that the clinical approach to treat allergies and gastrointestinal ailments was revolutionized. The pharmacological treatment of peptic ulcer and gastroesophageal reflux was indeed a revolution, as it ended the surgical intervention. Interest in histamine pharmacology was resurrected by the discovery of another histamine receptor, number 4, using genomics-based reverse pharmacological approaches for screening orphan GPCRs. This receptor is preferentially expressed by immune cells and its discovery raised hopes for its translational exploitation as a new therapeutic target for unmet medical needs ranging from asthma to cancer. However, several drawbacks emerged and dramatically slowed down research in the field. A better understanding of receptor intra-and interspecies heterogeneity will certainly improve and accelerate the translation of experimental data into clinical practice. Also, the plethora of data on brain histamine is hinting at a fundamental role of this system as a hub that receives internal and peripheral stimuli to allocate the necessary excitation to specific brain circuits that preside the appropriate behavioral responses. The development of new histaminergic ligands is an ongoing process that constantly provide new preclinical tools. The aim of this book is to cover the most important aspects of histamine receptor function and pharmacology in the central nervous system and to provide a comprehensive overview of the preclinical and clinical advances made in recent decades and the exciting prospects for the future. It highlights the clinical areas where there is a great need for new therapeutic approaches and where novel histaminergic agents may be useful for personalized medicine.
Описание: In Functional Selectivity of G Protein-Coupled Receptors, experts review the work that demonstrated the existence of functional selectivity, placed it within a theoretical framework, and provided a mechanistic basis for the phenomenon.
Автор: Olimpia Meucci Название: Chemokine Receptors and NeuroAIDS ISBN: 1489984879 ISBN-13(EAN): 9781489984876 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Since their discovery as HIV co-receptors in 1996, chemokine receptors have been widely studied within the field of HIV pathogenesis, including neuroAIDS. However, though their role in infection of target cells and in inflammatory/immune responses is relatively well-characterized, their relevance with respect to neuropathogenesis is still unclear.
Автор: Katharine Herrick-Davis; Graeme Milligan; Giuseppe Название: G-Protein-Coupled Receptor Dimers ISBN: 3319601725 ISBN-13(EAN): 9783319601724 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: G-protein-coupled receptors (GPCRs) are believed to be the largest family of membrane proteins involved in signal transduction and cellular responses.
Автор: Jarisch Reinhart Название: Histamine Intolerance: Histamine and Seasickness ISBN: 3642554466 ISBN-13(EAN): 9783642554469 Издательство: Springer Рейтинг: Цена: 11179.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Histamine is an important mediator of allergic diseases, but knowledge of histamine as a cause of numerous non-allergic symptoms and signs is limited. This book offers wide-ranging coverage of histamine intolerance. There is extensive background discussion of the origin of histamine, its content in food and alcoholic beverages and intolerance to red wine. Diagnosis of histamine intolerance is explained and the various symptoms of histamine intolerance are clearly described. Subsequent chapters cover the relation of histamine to a wide variety of conditions, including drug intolerance, atopic dermatitis, seasickness and osteoporosis. This book will prove of value in clinical practice by facilitating differential diagnosis, which is by no means straightforward given the multiplicity of symptoms of histamine intolerance and by assisting in the selection of therapeutic measures.
Автор: Kenji Tasaka Название: New Advances in Histamine Research ISBN: 4431682651 ISBN-13(EAN): 9784431682653 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Recent research has given great insight into the physiological and pharmaceutical effects of histamine on the central nervous system and especially on the brain. Also featured are the mechanisms of histamine release in bone marrow and mast cells and the role of histamine in neutrophil differentiation.
Автор: B?rje Uvn?s Название: Histamine and Histamine Antagonists ISBN: 3642758428 ISBN-13(EAN): 9783642758423 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With contributions by numerous experts
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