Chemokine Receptors and NeuroAIDS, Olimpia Meucci

Автор: Pere Santamaria; Peter Hackett
Название: Cytokines and Chemokines in Autoimmune Disease
ISBN: 1461349524 ISBN-13(EAN): 9781461349525
Издательство: Springer
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Описание: This volume is ideal for individuals interested in taking an in-depth look at how cytokines and chemokines participate in autoimmune disorders, and how cytokines and chemokines can be used as targets for therapeutic intervention.

Автор: Jeffrey K. Harrison; Nicholas W. Lukacs
Название: The Chemokine Receptors
ISBN: 1617377686 ISBN-13(EAN): 9781617377686
Издательство: Springer
Цена: 28732.00 р.
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Описание: G-protein coupled receptors (GPCRs) constitute a large superfamily of proteins that have been historically well represented as drug targets. As such, many of the volumes within The Receptors series have focused their attention on rec- tor subfamilies in the GPCR superfamily (e. g., adrenergic, serotonergic, do- minergic). While chemokine receptors are relatively young, in terms of the knowledge that has accumulated regarding their roles in physiology and pat- logy, it is clear that this GPCR subfamily is dwar? ng all others with respect to the total number of receptors and their functional diversity. The breadth of the chemokine ? eld was not fully appreciated in the early days of chemokine d- covery, when the characterization of these molecules was largely a curiosity of a small set of biologists primarily interested in in? ammation. Presently, the ? eld of chemokinology is quite diverse, and it is nearly impossible to stay informed on all aspects of chemokine biology. Nonetheless, this book seeks to distill information regarding the molecular and cell biology, physiology, and pathology of chemokines and their receptors into a single volume, providing an excellent resource for those entering the ? eld or the most experienced c- mokinologist seeking new insights. In the chapters, leading authorities consider structural and cellular aspects of chemokines and chemokine receptors, and more notably, discuss the roles of these molecules in a variety of disease states that transcend their classically de? ned role(s) in in? ammation.

Автор: Paul Shapshak; Andrew J. Levine; Brian T. Foley; C
Название: Global Virology II - HIV and NeuroAIDS
ISBN: 149397288X ISBN-13(EAN): 9781493972883
Издательство: Springer
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Описание: ForwardPreface
Chapter 1Multidisciplinary Approach to HIV/AIDS: Historical PerspectiveClyde B. McCoy*, A. Jeanene Bengoa*, Duane C. McBride, Brian T. Foley, Shikha Puri, Alejandro J. Mendez, and Paul Shapshak
Chapter 2Global Issues in NeuroAIDSJennifer Massey* and Bruce Brew
Chapter 3HIV-1 related Central Nervous System Diseases: Pathogenesis, Diagnosis, and Treatment - An Indian ScenarioSudharsana Sundarrajan, Sajitha Lulu, and Mohanapriya Arumugam*
Chapter 4HIV-1 Diversity in BrazilRodrigo Pessфa and Sabri Saeed Sanabani*
Chapter 5HIV and SIV EvolutionBrian T. Foley*
Chapter 6Human Brain Imaging in HIV and NeuroAIDSMona A. Mohamed* and Peter Barker
Chapter 7HIV Neuroinvasion Suzanne Gartner* and Yiling Liu
Chapter 8Neuropathology of HIV-1 DiseaseVirawudh Soontornniyomkij*
Chapter 9HIV-related Peripheral Nervous System IllnessJocelyn Jiao, David M. Simpson, and Jessica Robinson-Papp*
Chapter 10The Role of Early Life Programming in Vulnerability and Resilience in Relation to HIVLuba Sominsky* and Deborah Hodgson
Chapter 11Neurocognition in Viral Suppressed HIV-Infected ChildrenClaudia S. Crowell* and Kathleen Malee
Chapter 12Psychiatric Comorbidities in HIV-InfectionApril D. Thames* and Jacob D. Jones
Chapter 13Toward an Iterative Approach to Preventing HIV Risk Among Young MSMJ. Bryan Page
Chapter 14NeuroAIDS in Drug Abusers - Associations with Oral ManifestationsFariba S. Younai*
Chapter 15Socioepidemiology of Injection Drug Users in Miami and HIV-1B Envelope (V1-V5) Genetic Diversity: A Preliminary StudyPaul Shapshak*, Brian T. Foley, Seetharaman Balaji, David M. Segal, Clyde McCoy, and J. Bryan Page
Chapter 16The persistence of HIV associated neurocognitive disorder (HAND) in the era of combined antiretroviral therapy (cART)Elyse J. Singer* and Natasha M. Nemanim
Chapter 17Antiretroviral Therapy - Brain PenetrationCharurut Somboonwit*, Jose A Montero, John T. Sinnott, and Paul Shapshak
Chapter 18Molecular Mechanisms of Cognitive Impairment in Patients with HIV Infection: Application of Bioinformatics and Data-MiningLuca Giacomelli*, Francesco Chiappelli, Bruno Orlando, Victor Sivozhelezov, and Roberto Eggenhцffner

Chapter 19Genetic, Epigenetic, and Transcriptomic Studies of NeuroAIDS Andrew J. Levine*, Kumud K. Singh, Asha R. Kallianpur
Chapter 20NeuroAIDS: A Review of Gene Expression in Neurons, Astrocytes and OligodendrocytesJeanie McGee and Alireza Minagar*
Chapter 21Neuronal Apoptotic Pathways in HIV Associated Dementia, Alzheimer's Disease, Parkinson's Disease, and Huntington's DiseaseFatten F. Elkomy, Andrew J. Levine, Elyse Singer, Charurut Somboonwit, Todd Wills, Kaley Tash, John T. Sinnott, Sally Alrabaa, Anteneh Addisu, Hector Rodriguez, Francesco Chiappelli, Toni Kazic, and Paul Shapshak*
Chapter 22Clinical Relevance of Humanized MiceRachel Samantha Resop, Irene Jane Kim, Huy Nguyen, and Dimitrios Nikolaos Vatakis*

Автор: Nuska Tschammer
Название: Chemokines
ISBN: 3319347837 ISBN-13(EAN): 9783319347837
Издательство: Springer
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Описание: Introduction.- Insights in the chemokine receptor structures and drug design approaches in chemokine receptors.- Therapeutic targeting of CXCR3 chemokine receptor by small molecules.- Allosteric modulation of chemokine receptors.- Chemokines and their receptors in CNS.- Chemokine receptors in allergy and inflammation

Автор: Kownatzki; Norgauer
Название: Chemokines and Skin
ISBN: 3034897979 ISBN-13(EAN): 9783034897976
Издательство: Springer
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Описание: The accumulation of white blood cells is a hallmark of inflammation. The penetra- tion through the vessel walls and the infiltration around the inflammatory stimulus is a complex process which involves active adherence and directed migration of the inflammatory cells. Chemotactic factors stimulate both adherence and migration. Technical tools such as the Boyden chamber 1] made it possible to study leukocyte migration in vitro. This technique allows differentiation between migration direct- ed towards a chemotactic stimulus and non-directed migration. Until a decade ago only two naturally occurring molecules had been clearly iden- tified as potent chemotactic attractants of neutrophilic granulocytes. They were the split product of the fifth complement component C5a 2] and the arachidonic acid metabolite leukotriene B4 3]. In 1986, a novel human monocyte-derived chemo- taxin attracting neutrophilic granulocytes with a similar potency was found 4]. This report was quickly confirmed by several groups 5-8]. The new factor was purified, cloned and sequenced 9, 10]. The term "interleukin 8" (IL-8) replaced the various names proposed previously 4-8]. Sequence data revealed that IL-8 belonged to a large family of chemotactic cytokines, now called "chemokines" 11]. Four subfamilies were distinguished on the basis of the number and position of the first cysteine residues. They are desig- nated accordingly as C, CC, CXC and CX C chemokines 11-13]. The number of 3 human chemokines identified so far is close to 40 11-13].

Автор: Malak Kotb; Thierry Calandra
Название: Cytokines and Chemokines in Infectious Diseases Handbook
ISBN: 1617372471 ISBN-13(EAN): 9781617372476
Издательство: Springer
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Описание: A comprehensive review of what is known about the role of cytokines and chemokines in a variety of human infectious diseases, including gram-negative and -positive infections, listeriosis, mycobacterial infections, lyme arthritis, pneumonia, fungal infections, HIV, leishmaniasis, and sepsis.

Автор: I.J.D. Lindley; J. Westwick; S. Kunkel
Название: The Chemokines
ISBN: 1461362830 ISBN-13(EAN): 9781461362838
Издательство: Springer
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Описание: The Second International Symposium on Chemotactic Cytokines was held at the same venue in June 1990, and a much-increased attendance reflected the accelerating pace of work in the area of these chemotactic cytokines.