Chemokines and Skin, Kownatzki; Norgauer

Автор: Nuska Tschammer
Название: Chemokines
ISBN: 3319347837 ISBN-13(EAN): 9783319347837
Издательство: Springer
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Цена: 28732.00 р.
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Описание: Introduction.- Insights in the chemokine receptor structures and drug design approaches in chemokine receptors.- Therapeutic targeting of CXCR3 chemokine receptor by small molecules.- Allosteric modulation of chemokine receptors.- Chemokines and their receptors in CNS.- Chemokine receptors in allergy and inflammation

Автор: I.J.D. Lindley; J. Westwick; S. Kunkel
Название: The Chemokines
ISBN: 1461362830 ISBN-13(EAN): 9781461362838
Издательство: Springer
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Описание: The Second International Symposium on Chemotactic Cytokines was held at the same venue in June 1990, and a much-increased attendance reflected the accelerating pace of work in the area of these chemotactic cytokines.

Автор: Olimpia Meucci
Название: Chemokine Receptors and NeuroAIDS
ISBN: 1489984879 ISBN-13(EAN): 9781489984876
Издательство: Springer
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Описание: Since their discovery as HIV co-receptors in 1996, chemokine receptors have been widely studied within the field of HIV pathogenesis, including neuroAIDS. However, though their role in infection of target cells and in inflammatory/immune responses is relatively well-characterized, their relevance with respect to neuropathogenesis is still unclear.

Автор: Jeffrey K. Harrison; Nicholas W. Lukacs
Название: The Chemokine Receptors
ISBN: 1617377686 ISBN-13(EAN): 9781617377686
Издательство: Springer
Цена: 28732.00 р.
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Описание: G-protein coupled receptors (GPCRs) constitute a large superfamily of proteins that have been historically well represented as drug targets. As such, many of the volumes within The Receptors series have focused their attention on rec- tor subfamilies in the GPCR superfamily (e. g., adrenergic, serotonergic, do- minergic). While chemokine receptors are relatively young, in terms of the knowledge that has accumulated regarding their roles in physiology and pat- logy, it is clear that this GPCR subfamily is dwar? ng all others with respect to the total number of receptors and their functional diversity. The breadth of the chemokine ? eld was not fully appreciated in the early days of chemokine d- covery, when the characterization of these molecules was largely a curiosity of a small set of biologists primarily interested in in? ammation. Presently, the ? eld of chemokinology is quite diverse, and it is nearly impossible to stay informed on all aspects of chemokine biology. Nonetheless, this book seeks to distill information regarding the molecular and cell biology, physiology, and pathology of chemokines and their receptors into a single volume, providing an excellent resource for those entering the ? eld or the most experienced c- mokinologist seeking new insights. In the chapters, leading authorities consider structural and cellular aspects of chemokines and chemokine receptors, and more notably, discuss the roles of these molecules in a variety of disease states that transcend their classically de? ned role(s) in in? ammation.