Автор: Tracy Handel Название: Chemokines,570 ISBN: 0128021713 ISBN-13(EAN): 9780128021712 Издательство: Elsevier Science Рейтинг: Цена: 24423.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
"Chemokines," the latest volume in the "Methods in Enzymology" series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in chemokines, and includes sections on such topics as chemokine detection using receptors, tracking cellular responses to chemokines, recognition of GAG-bound chemokines, and the production of chemokine receptor complexes for structural and biophysical studies. Continues the legacy of this premier serial with quality chapters authored by leaders in the fieldCovers research methods in chemokinesContains sections on such topics as chemokine detection using receptors, tracking cellular responses to chemokine, recognition of GAG-bound chemokines, and the production of chemokine receptor complexes for structural and biophysical studies
Автор: I.J.D. Lindley; J. Westwick; S. Kunkel Название: The Chemokines ISBN: 1461362830 ISBN-13(EAN): 9781461362838 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The Second International Symposium on Chemotactic Cytokines was held at the same venue in June 1990, and a much-increased attendance reflected the accelerating pace of work in the area of these chemotactic cytokines.
Автор: Kownatzki; Norgauer Название: Chemokines and Skin ISBN: 3034897979 ISBN-13(EAN): 9783034897976 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The accumulation of white blood cells is a hallmark of inflammation. The penetra- tion through the vessel walls and the infiltration around the inflammatory stimulus is a complex process which involves active adherence and directed migration of the inflammatory cells. Chemotactic factors stimulate both adherence and migration. Technical tools such as the Boyden chamber 1] made it possible to study leukocyte migration in vitro. This technique allows differentiation between migration direct- ed towards a chemotactic stimulus and non-directed migration. Until a decade ago only two naturally occurring molecules had been clearly iden- tified as potent chemotactic attractants of neutrophilic granulocytes. They were the split product of the fifth complement component C5a 2] and the arachidonic acid metabolite leukotriene B4 3]. In 1986, a novel human monocyte-derived chemo- taxin attracting neutrophilic granulocytes with a similar potency was found 4]. This report was quickly confirmed by several groups 5-8]. The new factor was purified, cloned and sequenced 9, 10]. The term "interleukin 8" (IL-8) replaced the various names proposed previously 4-8]. Sequence data revealed that IL-8 belonged to a large family of chemotactic cytokines, now called "chemokines" 11]. Four subfamilies were distinguished on the basis of the number and position of the first cysteine residues. They are desig- nated accordingly as C, CC, CXC and CX C chemokines 11-13]. The number of 3 human chemokines identified so far is close to 40 11-13].
Автор: Astrid E. Cardona; Eroboghene E. Ubogu Название: Chemokines ISBN: 1627034250 ISBN-13(EAN): 9781627034258 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Methods in Molecular Biology book offers experimental models and state-of-the-art methods used to delineate chemokine/chemokine receptor function and applications in health and disease. Includes materials lists, reproducible protocols, pitfalls and more.
Автор: Astrid E. Cardona; Eroboghene E. Ubogu Название: Chemokines ISBN: 1493960059 ISBN-13(EAN): 9781493960057 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Methods in Molecular Biology book offers experimental models and state-of-the-art methods used to delineate chemokine/chemokine receptor function and applications in health and disease. Includes materials lists, reproducible protocols, pitfalls and more.
Автор: Nuska Tschammer Название: Chemokines ISBN: 3319140590 ISBN-13(EAN): 9783319140599 Издательство: Springer Рейтинг: Цена: 36570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Introduction.- Insights in the chemokine receptor structures and drug design approaches in chemokine receptors.- Therapeutic targeting of CXCR3 chemokine receptor by small molecules.- Allosteric modulation of chemokine receptors.- Chemokines and their receptors in CNS.- Chemokine receptors in allergy and inflammation
Автор: Amanda E.I. Proudfoot; Timothy N.C. Wells; Christi Название: Chemokine Protocols ISBN: 0896037223 ISBN-13(EAN): 9780896037229 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: What has emerged over the years is that most chemokine receptors bind several distinct ligands, and indeed the majority of chemokines are able to bind to multiple chemokine receptors, explaining to some extent the apparent disparity in the numbers of chemokines and rec- tors.
Автор: Olimpia Meucci Название: Chemokine Receptors and NeuroAIDS ISBN: 1489984879 ISBN-13(EAN): 9781489984876 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Since their discovery as HIV co-receptors in 1996, chemokine receptors have been widely studied within the field of HIV pathogenesis, including neuroAIDS. However, though their role in infection of target cells and in inflammatory/immune responses is relatively well-characterized, their relevance with respect to neuropathogenesis is still unclear.
Автор: Jeffrey K. Harrison; Nicholas W. Lukacs Название: The Chemokine Receptors ISBN: 1617377686 ISBN-13(EAN): 9781617377686 Издательство: Springer Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: G-protein coupled receptors (GPCRs) constitute a large superfamily of proteins that have been historically well represented as drug targets. As such, many of the volumes within The Receptors series have focused their attention on rec- tor subfamilies in the GPCR superfamily (e. g., adrenergic, serotonergic, do- minergic). While chemokine receptors are relatively young, in terms of the knowledge that has accumulated regarding their roles in physiology and pat- logy, it is clear that this GPCR subfamily is dwar? ng all others with respect to the total number of receptors and their functional diversity. The breadth of the chemokine ? eld was not fully appreciated in the early days of chemokine d- covery, when the characterization of these molecules was largely a curiosity of a small set of biologists primarily interested in in? ammation. Presently, the ? eld of chemokinology is quite diverse, and it is nearly impossible to stay informed on all aspects of chemokine biology. Nonetheless, this book seeks to distill information regarding the molecular and cell biology, physiology, and pathology of chemokines and their receptors into a single volume, providing an excellent resource for those entering the ? eld or the most experienced c- mokinologist seeking new insights. In the chapters, leading authorities consider structural and cellular aspects of chemokines and chemokine receptors, and more notably, discuss the roles of these molecules in a variety of disease states that transcend their classically de? ned role(s) in in? ammation.
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