Описание: This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels.
Автор: Bernd Nilius; Veit Flockerzi Название: Mammalian Transient Receptor Potential (TRP) Cation Channels ISBN: 3319051601 ISBN-13(EAN): 9783319051604 Издательство: Springer Рейтинг: Цена: 41925.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression. Thereby this volume on Transient Receptor Potential (TRP) Channels provides valuable information for readers with different expectations and backgrounds, for those who are approaching this field of research as well as for those wanting to make a trip to TRPs.
Автор: Bernd Nilius; Veit Flockerzi Название: Mammalian Transient Receptor Potential (TRP) Cation Channels ISBN: 364254214X ISBN-13(EAN): 9783642542145 Издательство: Springer Рейтинг: Цена: 53106.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this fast moving field the main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field will describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression. Thereby this volume on Transient Receptor Potential (TRP) Channels provides valuable information for readers with different expectations and backgrounds, for those who are approaching this field of research as well as for those wanting to make a trip to TRPs.
Автор: Szallasi Arpad, Bнrу Tamбs Название: Trp Channels in Drug Discovery: Volume II ISBN: 1493960660 ISBN-13(EAN): 9781493960668 Издательство: Springer Рейтинг: Цена: 25853.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels has attracted a great deal of well-deserved attention. TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field. Volume II presents practical methodologies involving models for disorders of the cardiovascular system, the brain, skin, the metabolic system, as well as colitis, cancer, thermosensation, and musculoskeletal disorders. Written for the Methods in Pharmacology and Toxicology™ series, this work includes the kind of detailed description and key implementation advice that ensures successful results in the lab. Comprehensive and cutting-edge, TRP Channels in Drug Discovery serves as an ideal reference for graduate students in academic laboratories as well as for pharmaceutical scientists developing new drugs and clinicians interested in novel drugs in the pipeline.
Автор: Arpad Szallasi; Tam?s B?r? Название: TRP Channels in Drug Discovery ISBN: 1493962817 ISBN-13(EAN): 9781493962815 Издательство: Springer Рейтинг: Цена: 25853.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With state-of-the-art reviews of the most interesting TRP channels, from TRPA1 to TRPV4, this volume contains key tips on implementation as well as clear and focused laboratory-ready protocols on TRP channels and disorders of airways and the GU tract.
Название: TRP Channels ISBN: 1138116165 ISBN-13(EAN): 9781138116160 Издательство: Taylor&Francis Рейтинг: Цена: 11482.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
The rapid expansion of the TRP field has generated a large amount of excellent original work across many different research fields. However, investigators are not necessarily familiar with the pros and cons of the variety of methods used to study TRP channels. Because of functional and genetic diversity, as well as the different physiological roles they play, techniques used for studying TRP channels range from single molecular analysis to behavioral animal studies. Methods in multiple areas, such as molecular biology, fluorescence imaging, electrophysiology, cell biology, genetics, proteomics, pharmacology, system physiology, and behavioral assessment, are employed to investigate various aspects of these channels. Choosing among many possible topics in these broad areas was a daunting task.
A comprehensive review of the field, TRP Channels spans the information gap by providing broad coverage of current methods and techniques commonly used in TRP channel research, and detailed protocols with thorough discussions of the advantages and disadvantages across methods. Some topics covered include
Mammalian, Drosophila and C. elegans TRP channels
Practical protocols for functional studies of TRP channels, including TRPC, TRPV, TRPA, TRPM and the intracellularly localized TRPML channels
ThermoTRPs, including the new fast temperature jump apparatus and the high throughput random mutagenesis method for screening critical motifs involved in TRP channel regulation
Cell-based high-throughput screening assays for TRP channels and their applications in drug discoveries
TRP channel functions in native cells, including smooth muscles, neurons, and cancers
Showcasing the current status of the field, TRP Channels covers the major techniques used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Because of the breadth of the TRP field, the applications of some methods are described in multiple chapters by experts working on a variety of channel types that serve different physiological functions, highlighting distinctive views on how the methodology can be utilized. Some chapters include discussion on the usefulness and pitfalls associated with the use of certain techniques. Together with chapters that offer comprehensive reviews on the functional regulation and other roles of TRP channels, students and investigators new to the field should find this book particularly informative.
Название: Neurobiology of TRP Channels ISBN: 1498755240 ISBN-13(EAN): 9781498755245 Издательство: Taylor&Francis Рейтинг: Цена: 27562.00 р. Наличие на складе: Поставка под заказ.
Автор: Rosenbaum Emir, Tamara Lu Название: Neurobiology of TRP Channels ISBN: 0367735806 ISBN-13(EAN): 9780367735807 Издательство: Taylor&Francis Рейтинг: Цена: 7348.00 р. Наличие на складе: Поставка под заказ.
Автор: Stephen W. Schaffer; Ming Li Название: T-type Calcium Channels in Basic and Clinical Science ISBN: 3709119545 ISBN-13(EAN): 9783709119549 Издательство: Springer Рейтинг: Цена: 16977.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The first full treatment of this developing field of research, this collection addresses new therapeutic concepts derived from work on the T-type calcium channel, its molecular, biophysical, and pharmacological properties, and its role in disease pathogenesis.
Автор: Zamponi Название: Voltage-Gated Calcium Channels ISBN: 3031088832 ISBN-13(EAN): 9783031088834 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing. Finally, the book also provides an overview of the updated research on calcium channel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery.
Автор: Sonkusare, Swapnil K. Название: Role Of Trpv4 Channels In Different Organ Systems,89 ISBN: 0323997821 ISBN-13(EAN): 9780323997829 Издательство: Elsevier Science Рейтинг: Цена: 23917.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Rethinking Politeness with Henri Bergson offers the first English translation of a little-known essay by influential French philosopher Henri Bergson on the classifications of politeness acts. The translation is followed by a series of essays from scholars who critically engage with and build on Bergson`s ideas, and recontextualize politeness as a key dimension of human sociability.
Автор: Serysheva, Irina Название: Structure And Function Of Calcium Release Channels,66 ISBN: 012381037X ISBN-13(EAN): 9780123810373 Издательство: Elsevier Science Рейтинг: Цена: 25602.00 р. Наличие на складе: Поставка под заказ.
Описание: Focuses on Membrane Protein Crystallization, beginning with a review of past successes and general trends, then further discussing challenges of membranes protein crystallization, cell free production of membrane proteins and novel lipids for membrane protein crystallization.
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