Описание: This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels.
Автор: Norbert Weiss; Alexandra Koschak Название: Pathologies of Calcium Channels ISBN: 364240281X ISBN-13(EAN): 9783642402814 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Calcium ions are crucial regulators of human physiology and development. This comprehensive guide to the molecular and clinical characteristics of the channels by which they cross membranes covers the diseases affecting them and a range of promising therapies.
Автор: Stephen W. Schaffer; Ming Li Название: T-type Calcium Channels in Basic and Clinical Science ISBN: 3709119545 ISBN-13(EAN): 9783709119549 Издательство: Springer Рейтинг: Цена: 16977.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The first full treatment of this developing field of research, this collection addresses new therapeutic concepts derived from work on the T-type calcium channel, its molecular, biophysical, and pharmacological properties, and its role in disease pathogenesis.
Автор: Gerald Werner Zamponi Название: Voltage-Gated Calcium Channels ISBN: 1441934111 ISBN-13(EAN): 9781441934116 Издательство: Springer Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: oltage-gated calcium channels are essential mediators of a range of physiological functions, including the communication between nerve Vcells, the regulation of heart beat, muscle contraction, and secretion of hormones such as insulin. Consequently, these channels are critical phar- macological targets in the treatment of a variety of disorders, such as epi- lepsy, hypertension, and pain. Voltage-gated calcium channels have there- fore been subject to intense study by numerous investigators over the past few decades, and an immense body of work has accumulated. In this book, we provide the first comprehensive overview of our current state of knowl- edge concerning this exciting field of research. Leading off with a general review of calcium signaling and techniques to measure calcium channel ac- tivity, the book delves into a provocative overview of the history of the cal- cium channel field, contributed by one of the key pioneers in the field. Dr. Richard Tsien. This is followed by an in depth review of the biochemical and molecular biological characterization of calcium channel genes by Drs. Catterall and Snutch whose research has resulted in major advances in the calcium channel field. A number of chapters are dedicated towards various aspects of calcium channel structure and function, including channel gat- ing, permeation, modulation and interactions with members of the exo- totic machinery--contributed by both established leaders and rising stars in the field.
Автор: Zamponi Название: Voltage-Gated Calcium Channels ISBN: 3031088808 ISBN-13(EAN): 9783031088803 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing. Finally, the book also provides an overview of the updated research on calcium channel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery.
Описание: This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.
Автор: Peter C. Ruben Название: Voltage Gated Sodium Channels ISBN: 3642415873 ISBN-13(EAN): 9783642415876 Издательство: Springer Рейтинг: Цена: 46118.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
Автор: Peter C. Ruben Название: Voltage Gated Sodium Channels ISBN: 3662512025 ISBN-13(EAN): 9783662512029 Издательство: Springer Рейтинг: Цена: 43100.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume of Springer`s Handbook of Experimental Pharmacology explores the wide range of factors relating to sodium channels, from their biophysical behavior, structure, and pathological vulnerabilities to the methodologies employed in studying them.
Автор: Andre Kamkin; Ilya Lozinsky Название: Mechanically Gated Channels and their Regulation ISBN: 9400795505 ISBN-13(EAN): 9789400795501 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A welcome single-source study of molecular mechanisms for mechanosensing and mechanotransduction in cells, this book includes the latest research and focuses on key issues of mechanical stress influencing ion channels and intracellular signaling pathways.
Автор: Stephens Gary Название: Modulation of Presynaptic Calcium Channels ISBN: 9400763336 ISBN-13(EAN): 9789400763333 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents recent advances in knowledge of the regulation of presynaptic Ca2+ channels. These represent one of the most widely modulated proteins in the body, target of a range of effector pathways and drugs; this range will be fully represented here.
Автор: Jackson, William F. Название: Ion Channels And Calcium Signaling In The Microcirculation,85 ISBN: 0128200901 ISBN-13(EAN): 9780128200902 Издательство: Elsevier Science Рейтинг: Цена: 25265.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Ion Channels and Calcium Signaling in the Microcirculation, Volume 85, the latest release in the Current Topics in Membranes series, highlights the latest advances in the expression and function of ion channels and calcium signaling in vascular smooth muscle and endothelial cells in resistance arteries, arterioles and capillaries, critical components of microcirculation, the business end of the cardiovascular system. Leading experts have contributed chapters, including Smooth muscle ion channels and calcium signaling in the regulation of striated muscle arteriolar tone; Endothelial KIR channels as a key component of shear stress-induced mechanotransduction; Endothelial TRPV4 channels and vasodilator reactivity, and much more.
Additional sections cover cerebral capillary endothelial TRPA channels and the regulation of blood flow; Endothelial mineralocorticoid receptors and the regulation of TRPV4 function in cerebral parenchymal arterioles in hypertension; Subcellular calcium signaling and myogenic tone development in the retinal microcirculation; Microvascular KIR channels: Basis, properties and regulation by lipid and hemodynamic forces, Ion channels and calcium signaling in capillary endothelial cells; Ion channels and calcium signaling in bladder arterioles and resistance arteries, and Myoendothelial feedback and endothelial IKCa and sKCa channels.
Автор: Prakriya,Murali Название: Store-Operated Calcium Channels,71 ISBN: 0124078702 ISBN-13(EAN): 9780124078703 Издательство: Elsevier Science Рейтинг: Цена: 23917.00 р. Наличие на складе: Поставка под заказ.
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