Автор: Stephens Gary Название: Modulation of Presynaptic Calcium Channels ISBN: 9400763336 ISBN-13(EAN): 9789400763333 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents recent advances in knowledge of the regulation of presynaptic Ca2+ channels. These represent one of the most widely modulated proteins in the body, target of a range of effector pathways and drugs; this range will be fully represented here.
Автор: Charles Gerday; L. Bolis; R. Gilles Название: Calcium and Calcium Binding Proteins ISBN: 3642730442 ISBN-13(EAN): 9783642730443 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A Specialized Symposium Organized for the European Society for Comparative Physiology and Biochemistry in Crans-sur- Sierre, Switzerland, September 16-18, 1986
Автор: Klaus Groschner; Wolfgang F. Graier; Christoph Rom Название: Store-Operated Ca?? Entry (SOCE) Pathways ISBN: 331957731X ISBN-13(EAN): 9783319577319 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book thoroughly explores robotics in neurorehabilitative therapy, describing state-of-the-art applications of robotic devices for locomotion; posture and balance and upper extremity recovery in stroke. Includes schematic diagrams, photographs and tables.
Автор: Klaus Groschner; Wolfgang F. Graier; Christoph Rom Название: Store-Operated Ca?? Entry (SOCE) Pathways ISBN: 3319862367 ISBN-13(EAN): 9783319862361 Издательство: Springer Рейтинг: Цена: 34937.00 р. Наличие на складе: Поставка под заказ.
Описание: This book thoroughly explores robotics in neurorehabilitative therapy, describing state-of-the-art applications of robotic devices for locomotion; posture and balance and upper extremity recovery in stroke. Includes schematic diagrams, photographs and tables.
Автор: Stephen W. Schaffer; Ming Li Название: T-type Calcium Channels in Basic and Clinical Science ISBN: 3709114128 ISBN-13(EAN): 9783709114124 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: T-type calcium channels are prevalent in every organ of the body, and are believed to play a part in a variety of physiological processes, including contraction, shape change, secretion, endo- and exocytosis, cell proliferation and differentiation, modulation of enzyme function, and cell cycle progression. As such, research on the roles of these channels in a wide range of diseases has attracted increasing attention in recent years. The purpose of this book is to present a series of unique and comprehensive reviews of our current understanding of T-type calcium channels at the level of the basic sciences as well as the clinical sciences. For key organ systems, information is provided on the correlation between the molecular, biophysical and pharmacological properties of the channels, their cellular mechanisms, and their potential roles in the pathogenesis of various diseases. The compilation presents both commonplace and less well-known findings on these channels in a format designed to appeal to both casual readers and specialists in basic and clinical research on these transporters.
Автор: Stephen W. Schaffer; Ming Li Название: T-type Calcium Channels in Basic and Clinical Science ISBN: 3709119545 ISBN-13(EAN): 9783709119549 Издательство: Springer Рейтинг: Цена: 16977.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The first full treatment of this developing field of research, this collection addresses new therapeutic concepts derived from work on the T-type calcium channel, its molecular, biophysical, and pharmacological properties, and its role in disease pathogenesis.
Автор: Jackson, William F. Название: Ion Channels And Calcium Signaling In The Microcirculation,85 ISBN: 0128200901 ISBN-13(EAN): 9780128200902 Издательство: Elsevier Science Рейтинг: Цена: 25265.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Ion Channels and Calcium Signaling in the Microcirculation, Volume 85, the latest release in the Current Topics in Membranes series, highlights the latest advances in the expression and function of ion channels and calcium signaling in vascular smooth muscle and endothelial cells in resistance arteries, arterioles and capillaries, critical components of microcirculation, the business end of the cardiovascular system. Leading experts have contributed chapters, including Smooth muscle ion channels and calcium signaling in the regulation of striated muscle arteriolar tone; Endothelial KIR channels as a key component of shear stress-induced mechanotransduction; Endothelial TRPV4 channels and vasodilator reactivity, and much more.
Additional sections cover cerebral capillary endothelial TRPA channels and the regulation of blood flow; Endothelial mineralocorticoid receptors and the regulation of TRPV4 function in cerebral parenchymal arterioles in hypertension; Subcellular calcium signaling and myogenic tone development in the retinal microcirculation; Microvascular KIR channels: Basis, properties and regulation by lipid and hemodynamic forces, Ion channels and calcium signaling in capillary endothelial cells; Ion channels and calcium signaling in bladder arterioles and resistance arteries, and Myoendothelial feedback and endothelial IKCa and sKCa channels.
Автор: Stephens Gary, Mochida Sumiko Название: Modulation of Presynaptic Calcium Channels ISBN: 9401781095 ISBN-13(EAN): 9789401781091 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book will bring together leading international experts to discuss recent advances in basic scientific knowledge regarding the regulation of presynaptic Ca2+ channels. Importantly, Ca2+ channels represent one of the most widely modulated proteins in the body, being the target of a range of effector pathways and drugs; this range will be fully represented here. A number of therapeutic drugs target the Ca2+ channel complex, including the anti-epileptic gabapentinoid and analgesic ziconotide drugs and the pharmaceutical industry is searching for Ca2+ channel blocking drugs, particularly in the pain, epilepsy, ataxia and migraine areas. Such potential future therapies will be discussed here. Scientific disciplines will focus on electrophysiological studies, but will extend to neuroscience, genetics and biochemical areas. The work described will represent advances at the cutting edge of current neuroscience research and is timely and highly appropriate for the Springer book series.
Автор: Kozak, Juliusz Ashot Название: Calcium Entry Channels in Non-Excitable Cells ISBN: 0367657902 ISBN-13(EAN): 9780367657901 Издательство: Taylor&Francis Рейтинг: Цена: 7348.00 р. Наличие на складе: Поставка под заказ.
Автор: Zamponi Название: Voltage-Gated Calcium Channels ISBN: 3031088832 ISBN-13(EAN): 9783031088834 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing. Finally, the book also provides an overview of the updated research on calcium channel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery.
Автор: Zamponi Название: Voltage-Gated Calcium Channels ISBN: 3031088808 ISBN-13(EAN): 9783031088803 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing. Finally, the book also provides an overview of the updated research on calcium channel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for academic researchers at all levels in neuroscience, biophysics, cell biology and drug discovery.
Название: Calcium Entry Channels in Non-Excitable Cells ISBN: 1498752721 ISBN-13(EAN): 9781498752725 Издательство: Taylor&Francis Рейтинг: Цена: 24499.00 р. Наличие на складе: Поставка под заказ.
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